The Journal of Pediatrics
Volume 151, Issue 6 , Pages 700-703, December 2007

Clinical and Molecular Characteristics of Staphylococcal Skin Abscesses in Children

  • Howard Faden, MD

      Affiliations

    • Department of Pediatrics, Division of Infectious Diseases, State University of New York, Buffalo, New York
    • School of Medicine and Biomedical Sciences, Kaleida Health Buffalo, New York
    • Women and Children’s Hospital of Buffalo, Buffalo, New York
    • Corresponding Author InformationReprint requests: Dr Howard Faden, Division of Infectious Diseases, Women and Children’s Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222.
    • ,
  • Rebecca Rose, MD

      Affiliations

    • Department of Pediatric Surgery, State University of New York, Buffalo, New York
    • Women and Children’s Hospital of Buffalo, Buffalo, New York
    • ,
  • Alan Lesse, MD

      Affiliations

    • Departments of Medicine and Pharmacology and Toxicology, State University of New York, Buffalo, New York
    • VA Western New York Healthcare System, Buffalo, New York.
    • ,
  • Celeste Hollands, MD

      Affiliations

    • Department of Pediatric Surgery, State University of New York, Buffalo, New York
    • School of Medicine and Biomedical Sciences, Kaleida Health Buffalo, New York
    • Women and Children’s Hospital of Buffalo, Buffalo, New York
    • ,
  • Diane Dryja

      Affiliations

    • School of Medicine and Biomedical Sciences, Kaleida Health Buffalo, New York
    • ,
  • Philip L. Glick, MD

      Affiliations

    • Department of Pediatric Surgery, State University of New York, Buffalo, New York
    • School of Medicine and Biomedical Sciences, Kaleida Health Buffalo, New York
    • Women and Children’s Hospital of Buffalo, Buffalo, New York

Received 16 February 2007; received in revised form 29 May 2007; accepted 20 July 2007. published online 29 October 2007.

Forty-nine children with skin abscesses (36 methicillin-resistant Staphylococcus aureus and 13 methicillin-susceptible S aureus) exhibited similar disease severity. Both pathogen groups were pulse field type USA300, multilocus sequence type 8, and possessed Panton-Valentine leukocidin genes. Related microbial genetic architecture may account for similarities in disease severity despite differences in antibiotic susceptibility.

Abbreviations: ACME, Arginine catabolic mobile element, CA-MRSA, Community-acquired methicillin-resistant Staphylococcus aureus, MSSA, Methicillin susceptible Staphylococcus aureus, PFT, Pulse field type, PVL, Panton-Valentine leukocidin, SCCmec, Staphylococcal chromosomal cassette

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PII: S0022-3476(07)00702-0

doi:10.1016/j.jpeds.2007.07.040

Refers to article:

  • Staphylococcus Aureus: A Moving Target

    Arthur L. Frank
    The Journal of Pediatrics December 2007 (Vol. 151, Issue 6, Pages 561-563)

The Journal of Pediatrics
Volume 151, Issue 6 , Pages 700-703, December 2007

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