In vivo magnetic resonance spectroscopy of muscle

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Proton magnetic resonance spectroscopy was used in vivo to evaluate muscle metabolism in patients with neuromuscular diseases. The results show that children with Duchenne muscular dystrophy and spinal muscular atrophy have reduced tri-methyl-amid (TMA) peaks. TMA is involved in the metabolism of phospholipids and the decrease must represent a reduced rate of cell membrane synthesis, decreased cell turnover or a decreased cell number in these diseases that are characterized by fatty degeneration.

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