The Journal of Pediatrics
Volume 152, Issue 2 , Pages 263-269.e1 , February 2008

Interaction of Dopamine Transporter Genotype with Prenatal Smoke Exposure on ADHD Symptoms

  • Katja Becker, MD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • Corresponding Author InformationReprint requests: Katja Becker, MD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, PO Box 12 21 20, D-68072 Mannheim, Germany.
    • ,
  • Mahha El-Faddagh, MD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Center Karlsruhe, Karlsruhe, Germany
    • ,
  • Martin H. Schmidt, MD, PhD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • ,
  • Günter Esser, PhD

      Affiliations

    • Department of Psychology, Division of Clinical Psychology, University of Potsdam, Potsdam, Germany.
    • ,
  • Manfred Laucht, PhD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

Received 6 September 2006 ,Revised 14 May 2007 ,Accepted 2 July 2007.

References 

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed.. Washington DC: APA; 1994;
  2. Leibson CL, Katusic SK, Barbaresi WJ, Ransom J, O’Brien PC. Use and costs of medical care for children and adolescents with and without attention-deficit/hyperactivity disorder. JAMA. 2001;285:60–66
  3. Thapar A, Holmes J, Poulton K, Harrington R. Genetic basis of attention deficit and hyperactivity. Br J Psychiatry. 1999;174:105–111
  4. El Faddagh M, Laucht M, Maras A, Voehringer L, Schmidt MH. Association of dopamine D4 receptor (DRD4) gene with attention-deficit/hyperactivity disorder (ADHD) in a high-risk community sample: a longitudinal study from birth to 11 years of age. J Neural Transm. 2004;111:883–889
  5. Maher BS, Marazita ML, Ferrell RE, Vanyukov MM. Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis. Psychiatr Genet. 2002;12:207–215
  6. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1313–1323
  7. Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 1992;14:1104–1106
  8. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J. 2001;1:152–156
  9. Mill J, Asherson P, Browes C, D’Souza U, Craig I. Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet. 2002;114:975–979
  10. Kang AM, Palmatier MA, Kidd KK. Global variation of a 40-bp VNTR in the 3′-untranslated region of the dopamine transporter gene (SLC6A3). Biol Psychiatry. 1999;46:151–160
  11. Fisher SE, Francks C, McCracken JT, McGough JJ, Marlow AJ, MacPhie IL, et al. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet. 2002;70:1183–1196
  12. Roman T, Schmitz M, Polanczyk G, Eizirik M, Rohde LA, Hutz MH. Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet. 2001;105:471–478
  13. Todd RD, Jong YJ, Lobos EA, Reich W, Heath AC, Neuman RJ. No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins. Am J Med Genet. 2001;105:745–748
  14. Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry. 2003;160:1028–1040
  15. Milberger S, Biederman J, Faraone SV, Chen L, Jones J. Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children?. Am J Psychiatry. 1996;153:1138–1142
  16. Abell TD, Baker LC, Ramsey CN. The effects of maternal smoking on infant birth weight. Fam Med. 1991;23:103–107
  17. Olds D. Tobacco exposure and impaired development: a review of the evidence. Ment Retard Dev Disabil Res Rev. 2006;3:257–269
  18. Wisborg K, Kesmodel U, Henriksen TB, Olsen SF, Secher NJ. Exposure to tobacco smoke in utero and the risk of stillbirth and death in the first year of life. Am J Epidemiol. 2001;154:322–327
  19. Milberger S, Biederman J, Faraone SV, Jones J. Further evidence of an association between maternal smoking during pregnancy and attention deficit hyperactivity disorder: findings from a high-risk sample of siblings. J Clin Child Psychol. 1998;27:352–358
  20. Laucht M, Schmidt MH. [Maternal smoking during pregnancy: risk factor for ADHD in the offspring?]. Z Kinder Jugendpsychiatr Psychother. 2004;32:177–185
  21. Faraone SV, Doyle AE. The nature and heritability of attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin N Am. 2001;10:299–316
  22. Kahn RS, Khoury J, Nichols WC, Lanphear BP. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. J Pediatr. 2003;143:104–110
  23. Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, et al. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry. 2006;63:74–81
  24. Neuman RJ, Lobos E, Reich W, Henderson CA, Sun LW, Todd RD. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol Psychiatry. 2006;
  25. Laucht M, Esser G, Schmidt MH. Developmental outcome of infants born with biological and psychosocial risks. J Child Psychol Psychiatry. 1997;38:843–853
  26. Laucht M, Esser G, Baving L, Gerhold M, Hoesch I, Ihle W, et al. Behavioral sequelae of perinatal insults and early family adversity at 8 years of age. J Am Acad Child Adolesc Psychiatry. 2000;39:1229–1237
  27. Delmo C, Weiffenbach O, Gabriel M, Poustka F. Diagnostisches Interview Kiddie-Sads-Present and Lifetime-Version (K-SADS-PL) Screening Interview. 3. Auf-lage der deutschen Forschungsversion, erweitert um ICD-10-Diagnostik. Frankfurt: Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters; 2000.
  28. Rutter M, Quinton D. Psychiatric disorder—ecological factors and concepts of causation. In:  McGurk M editors. Ecological factors in human development. Amsterdam: North Holland; 1977;p. 173–187
  29. Becker K, Laucht M, El Faddagh M, Schmidt MH. The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample. J Neural Transm. 2005;112:847–858
  30. Biederman J, Faraone SV, Monuteaux MC. Differential effect of environmental adversity by gender: Rutter’s index of adversity in a group of boys and girls with and without ADHD. Am J Psychiatry. 2002;159:1556–1562
  31. Nathanielsz PW. Animal models that elucidate basic principles of the developmental origins of adult diseases. ILAR J. 2006;47:73–82
  32. Weissman MM, Warner V, Wickramaratne PJ, Kandel DB. Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood. J Am Acad Child Adolesc Psychiatry. 1999;38:892–899
  33. Ernst M, Moolchan ET, Robinson ML. Behavioral and neural consequences of prenatal exposure to nicotine. J Am Acad Child Adolesc Psychiatry. 2001;40:630–641
  34. Krause J, Krause KH, Dresel SH, La Fougere C, Ackenheil M. ADHD in adolescence and adulthood, with a special focus on the dopamine transporter and nicotine. Dialogues Clin Neurosci. 2006;8:29–36
  35. Cheon KA, Ryu YH, Kim JW, Cho DY. The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. Eur Neuropsychopharmacol. 2005;15:95–101
  36. Krause J, Dresel SH, Krause KH, La Fougere C, Zill P, Ackenheil M. Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele. World J Biol Psychiatry. 2006;7:152–157
  37. Lavalaye J, Booij J, Reneman L, Habraken JB, van Royen EA. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers. Eur J Nucl Med. 2000;27:867–869
  38. van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, et al. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J Nucl Med. 2005;46:745–751
  39. Laucht M, Becker K, Schmidt MH. Visual exploratory behaviour in infancy and novelty seeking in adolescence: two developmentally specific phenotypes of DRD4?. J Child Psychol Psychiatry. 2006;47:1143–1151
  40. Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry. 2003;60:837–844

 Supported by grants from the Deutsche Forschungsgemeinschaft (DFG) as part of the Special Research Program SFB 258 “Indicators and Risk Models of the Genesis and Course of Mental Disorders” at the University of Heidelberg, Germany.

PII: S0022-3476(07)00654-3

doi: 10.1016/j.jpeds.2007.07.004

The Journal of Pediatrics
Volume 152, Issue 2 , Pages 263-269.e1 , February 2008

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