The Journal of Pediatrics
Volume 151, Issue 5 , Pages 457-462.e1 , November 2007

Value of the Bronchodilator Response in Assessing Controller Naïve Asthmatic Children

  • Stanley P. Galant, MD

      Affiliations

    • Children’s Hospital of Orange County, Orange, California
    • Southern California Chapter of Asthma and Allergy Foundation of America, Los Angeles, California
    • Breathmobile Orange County.
    • Corresponding Author InformationReprint requests: Stanley P. Galant, MD, 1201 W La Veta Ave, Suite 501, Orange, Ca 92868.
  • ,
  • Tricia Morphew, MS

      Affiliations

    • Southern California Chapter of Asthma and Allergy Foundation of America, Los Angeles, California
  • ,
  • Silvia Amaro, RN

      Affiliations

    • Children’s Hospital of Orange County, Orange, California
    • Breathmobile Orange County.
  • ,
  • Otto Liao, MD

      Affiliations

    • Children’s Hospital of Orange County, Orange, California
    • Breathmobile Orange County.

Received 14 February 2007 ,Revised 1 May 2007

References 

  1. National Asthma Education and Prevention Program (NAEPP). Expert panel report: guidelines for the diagnosis and management of asthma—update on selected topics 2002. Bethesda, MD: NIH; 2002;NIH Publication 02-5075
  2. Russell NJ, Crichton NJ, Emerson PA, Morgan AD. Quantitative assessment of the value of spirometry. Thorax. 1986;41:360–363
  3. Halterman JS, Yoos HL, Kaczorowski JM, McConnochie K, Holzhauer RJ, Conn KM, et al. Providers underestimate symptom severity among urban children with asthma. Arch Pediatr Adolesc Med. 2002;156:141–146
  4. Holt EW, Tan J, Hosgood HD. The impact of spirometry on pediatric asthma diagnosis and treatment. J Asthma. 2006;43:489–493
  5. Nair ST, Daigle KL, De Cuir P, Lapin CD, Schramm CM. The influence of pulmonary function testing in the management of asthma in children. J Pediatr. 2005;147:797–801
  6. Werk LN, Steinbach S, Adams WG, Baucher H. Belief about diagnosing asthma in young children. Pediatrics. 2000;105:585–590
  7. Bacharier LB, Strunk RC, Mauger D, White D, Lemanske RF, Sorkness CA. Classifying asthma severity in children (Mismatch between symptoms, medication use, and lung function). Am J Respir Crit Care Med. 2004;176:426–432
  8. Spahn JD, Cherniack R, Paull K, Gelfand EW. Is forced expiratory volume in one second the best measure of severity in childhood asthma?. Am J Respir Crit Care Med. 2004;169:784–786
  9. Waalkens Aj, Merkus PJF, Van Essen-Zanduliet EEM, Brand PLP, Gerritsen J, Duirerman EJ, et al. Assessment of bronchodilator response in children with asthma. Eur Respir J. 1993;6:645–651
  10. Dundas I, Chan EY, Bridge PD, McKenzie SA. Diagnostic accuracy of bronchodilator responsiveness in wheezing children. Thorax. 2005;60:13–16
  11. Covar RA, Szefler J, Martin RJ, Sundstrom DA, Silkoff DA, Murphy J, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild to moderate asthma. J Pediatr. 2003;142:469–475
  12. Strunk RC, Szefler ST, Phillips BR, Chinchilli VM, Larsen G, Hodgdon K, et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol. 2003;122:883–892
  13. Colon-Semidey A, Marshik P, Crowley M, Katz R, Kelly HW. Correlation between reversibility of airway obstruction and exhaled nitric oxide levels in children with stable asthma. Pediatr Pulmonol. 2000;30:385–392
  14. Faul JL, Demers EA, Burke CM, Poulter LW. Alterations in airway inflammation and lung function during corticosteroid therapy for atopic asthma. Chest. 2002;121:1414–1420
  15. American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis. 1991;144:1202–1218
  16. Liao O, Morphew T, Amaro S, Galant SP. The Breathmobile, a novel comprehensive school-based asthma care clinic for urban under privileged children. J School Health. 2006;76:313–319
  17. Aurora P, Stocks J, Oliver C, Saunders C, Castle R, Chaziparasidis G, et al. Quality control for spirometry in preschool children with and without lung disease. Am J Resp Crit Care Med. 2004;169:1152–1159
  18. Knudson RJ, Lebowitz MD, Holbert CJ, Burrows B. Changes in the normal maximal expiratory flow volume curve with growth and aging. Am Rev Respir Dis. 1983;127:725–734
  19. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29–36
  20. Nielsen KG, Bisgaard H. Discriminative capacity of bronchodilator response measured with three different lung function techniques in asthmatic and healthy children ages 2 to 5 years. Am J Respir Crit Care Med. 2001;164:554–559
  21. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax. 2003;58:494–499
  22. Bibi H, Montgomery M, Pasterkamp H, Chernick V. Relationship between response to inhaled salbutamol and methacholine bronchial provocation in children with suspected asthma. Pediatr Pulmonol. 1991;10:244–248
  23. Kumar A, Wang B, Wang X, Changzhong C, Yang J, Fu L, et al. Bronchodilator responses in Chinese children from asthma index families and the general population. J Allergy Clin Immunol. 2006;117:1257–1263
  24. Lorber DB, Kaltenborn W, Burrows B. Responses to isoproterenol in a general population sample. Am Rev Respir Dis. 1978;118:855–861
  25. Dales RE, Spitzer WO, Tousignant P, Schechter M, Suissa S. Clinical interpretation of airway response to a bronchodilator. Am Rev Respir Dis. 1988;317–320
  26. Strachan DP. Repeatability of ventilatory function measurements in a population survey of 7 year old children. Thorax. 1989;44:474–479
  27. Galant SP, Morphew T, Amaro S, Liao O. Current asthma guideline may not identify young children who have experienced significant morbidity. Pediatrics. 2006;117:1038–1045
  28. Robertson CF, Rubinfield AR, Bowes G. Pediatric asthma deaths in Victoria: the mild are at risk. Pediatr Pullmonol. 1992;13:95–100
  29. Adams RJ, Fuhlbrigge A, Finklestein JA, Lozano P, Livingston JM, Weiss KB, et al. Impact of inhaled antiinflammatory therapy on hospitalization and emergency department visits for children with asthma. Pediatrics. 2001;107:706–711
  30. Bacharier LB, Strunk RC. Asthma in older children. In:  Leung DYM,  Sampson AA,  Geha R,  Szefler SJ editor. Pediatric Allergy Principals and Practice. St. Louis: Mosby; 2003;p. 405–424
  31. Phelan PD, Robertson CR, Olinsky A. The Melbourns Asthma Study: 1964-1999. J Allergy Clin Immunol. 2002;109:189–194
  32. Fuhlbrigge AL, Weiss ST, Kuntz KM, Paltiel D. Forced expiratory volume in 1 second percentage improves the classification among children with asthma. Pediatrics. 2006;118:e347–e355
  33. Tantisira KG, Fuhlbrigge AL, Tonascia J, Van Natta MV, Zeiger RS, Strunk RL, et al. Bronchodilation and bronchocontriction: predictors of future lung function in childhood asthma. J Allergy Clin Immunol. 2006;117:1264–1271
  34. Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, et al. The predicting response to inhaled corticosteroid efficacy (PRICE) trial. J Allergy Clin Immunol. 2007;119:73–80
  35. Borish LC, Miller MK, Zheng B, Dolan CM, Deniz Y. Serum IgE and lung function in the TENOR asthma cohort. J Allergy Clin Immunol. 2004;114:S81

 Supported by grants from the California Wellness Foundation, Tobacco Settlement Revenue, and Asthma Chronic Lung Disease.

PII: S0022-3476(07)00453-2

doi: 10.1016/j.jpeds.2007.05.004

The Journal of Pediatrics
Volume 151, Issue 5 , Pages 457-462.e1 , November 2007