The Journal of Pediatrics
Volume 151, Issue 4 , Pages 359-363 , October 2007

IgE Food Sensitization in Infants with Eczema Attending a Dermatology Department

  • David J. Hill, FRACP

      Affiliations

    • Murdoch Children’s Research Institute, Melbourne, Australia
    • Corresponding Author InformationReprint requests: David Hill, FRACP, Senior Consultant Allergist, Murdoch Children’s Research Institute, Royal Children’s Hospital, Flemington Road, Parkville, Vic 3052, Australia.
    • ,
  • Ralf G. Heine, MD, FRACP

      Affiliations

    • Department of Allergy & Immunology, Royal Children’s Hospital, Melbourne, Australia
    • Murdoch Children’s Research Institute, Melbourne, Australia
    • Department of Paediatrics, University of Melbourne, Melbourne, Australia.
    • ,
  • Cliff S. Hosking, FRACP

      Affiliations

    • Department of Allergy & Immunology, Royal Children’s Hospital, Melbourne, Australia
    • ,
  • Jennifer Brown, SRN

      Affiliations

    • Department of Allergy & Immunology, Royal Children’s Hospital, Melbourne, Australia
    • ,
  • Leone Thiele, SRN

      Affiliations

    • Department of Allergy & Immunology, Royal Children’s Hospital, Melbourne, Australia
    • ,
  • Katrina J. Allen, PhD, FRACP

      Affiliations

    • Department of Allergy & Immunology, Royal Children’s Hospital, Melbourne, Australia
    • Murdoch Children’s Research Institute, Melbourne, Australia
    • Department of Paediatrics, University of Melbourne, Melbourne, Australia.
    • ,
  • John Su, FRACP

      Affiliations

    • Department of Dermatology, Royal Children’s Hospital, Melbourne, Australia
    • ,
  • George Varigos, FRACP

      Affiliations

    • Department of Dermatology, Royal Children’s Hospital, Melbourne, Australia
    • ,
  • John B. Carlin, PhD

      Affiliations

    • Clinical Epidemiology and Biostatistics Unit, Royal Children’s Hospital, Melbourne, Australia
    • Murdoch Children’s Research Institute, Melbourne, Australia
    • Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Received 2 October 2006 ,Revised 13 February 2007 ,Accepted 27 April 2007.

References 

  1. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004;113:651–657
  2. Hill DJ, Hosking CS. Food allergy and atopic dermatitis in infancy: an epidemiologic study. Pediatr Allergy Immunol. 2004;15:421–427
  3. Illi S, von ME, Lau S, Nickel R, Gruber C, Niggemann B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113:925–931
  4. Wadonda-Kabondo N, Sterne JA, Golding J, Kennedy CT, Archer CB, Dunnill MG. A prospective study of the prevalence and incidence of atopic dermatitis in children aged 0-42 months. Br J Dermatol. 2003;149:1023–1028
  5. Arshad SH, Stevens M, Hide DW. The effect of genetic and environmental factors on the prevalence of allergic disorders at the age of two years. Clin Exp Allergy. 1993;23:504–511
  6. Herd RM, Tidman MJ, Prescott RJ, Hunter JA. Prevalence of atopic eczema in the community: the Lothian Atopic Dermatitis Study. Br J Dermatol. 1996;135:18–19
  7. Su JC, Kemp AS, Varigos GA, Nolan TM. Atopic eczema: its impact on the family and financial cost. Arch Dis Child. 1997;76:159–162
  8. Hill DJ, Sporik R, Thorburn J, Hosking CS. The association of atopic dermatitis in infancy with immunoglobulin E food sensitization. J Pediatr. 2000;137:475–479
  9. Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA. Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics. 1998;101:E8
  10. Thompson MM, Hanifin JM. Effective therapy of childhood atopic dermatitis allays food allergy concerns. J Am Acad Dermatol. 2005;53:S214–S219
  11. Fennessy M, Coupland S, Popay J, Naysmith K. The epidemiology and experience of atopic eczema during childhood: a discussion paper on the implications of current knowledge for health care, public health policy and research. J Epidemiol Community Health. 2000;54:581–589
  12. Hill DJ, Heine RG, Hosking CS. The diagnostic value of skin prick testing in children with food allergy. Pediatr Allergy Immunol. 2004;15:435–441
  13. Berth-Jones J. Six-Area, Six-Sign Atopic Dermatitis (SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis. Br J Dermatol. 1996;135(Suppl 48):25–30
  14. Kunz B, Oranje AP, Labreze L, Stalder JF, Ring J, Taieb A. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1997;195:10–19
  15. Wolkerstorfer A, de Waard van der Spek FB, Glazenburg EJ, Mulder PG, Oranje AP. Scoring the severity of atopic dermatitis: the Three-Item Severity Score as a rough system for daily practice and as a pre-screening tool for studies. Acta Derm Venereol. 1999;79:356–359
  16. Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy. 2000;30:1540–1546
  17. García-Ara C, Boyano-Martínez T, Díaz-Peña JM, Martín-Muñoz F, Reche-Frutos M, Martín-Esteban M. Specific IgE levels in the diagnosis of immediate hypersensitivity to cow’s milk protein in the infant. J Allergy Clin Immunol. 2001;107:185–190
  18. Boyano MT, García-Ara C, Díaz-Peña JM, Muñoz FM, García SG, Esteban MM. Validity of specific IgE antibodies in children with egg allergy. Clin Exp Allergy. 2001;31:1464–1469
  19. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107:891–896
  20. Celik-Bilgili S, Mehl A, Verstege A, Staden U, Nocon M, Beyer K, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy. 2005;35:268–273
  21. Wood RA. The natural history of food allergy. Pediatrics. 2003;111:1631–1637
  22. Hill DJ, Hosking CS, Reyes-Benito LV. Reducing the need for food allergen challenges in young children: a comparison of in vitro with in vivo tests. Clin Exp Allergy. 2001;31:1031–1035
  23. Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113:805–819
  24. Knight AK, Shreffler WG, Sampson HA, Sicherer SH, Noone S, Mofidi S, et al. Skin prick test to egg white provides additional diagnostic utility to serum egg white–specific IgE antibody concentration in children. J Allergy Clin Immunol. 2006;117:842–847
  25. Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. J Immunol. 1997;159:2026–2032
  26. Niggemann B, Reibel S, Roehr CC, Felger D, Ziegert M, Sommerfeld C, et al. Predictors of positive food challenge outcome in non–IgE-mediated reactions to food in children with atopic dermatitis. J Allergy Clin Immunol. 2001;108:1053–1058
  27. Vance GH, Lewis SA, Grimshaw KE, Wood PJ, Briggs RA, Thornton CA, et al. Exposure of the fetus and infant to hen’s egg ovalbumin via the placenta and breast milk in relation to maternal intake of dietary egg. Clin Exp Allergy. 2005;35:1318–1326
  28. Heine RG, Hill DJ, Hosking CS. Primary prevention of atopic dermatitis in breast-fed infants: what is the evidence?. J Pediatr. 2004;144:564–567
  29. Palmer DJ, Gold MS, Makrides M. Effect of cooked and raw egg consumption on ovalbumin content of human milk: a randomized, double-blind, cross-over trial. Clin Exp Allergy. 2005;35:173–178
  30. Järvinen KM, Mäkinen-Kiljunen S, Suomalainen H. Cow’s milk challenge through human milk evokes immune responses in infants with cow’s milk allergy. J Pediatr. 1999;135:506–512
  31. American Academy of PediatricsCommittee on Nutrition. Hypoallergenic infant formulas. Pediatrics. 2000;106:346–349
  32. Friedman NJ, Zeiger RS. The role of breast-feeding in the development of allergies and asthma. J Allergy Clin Immunol. 2005;115:1238–1248
  33. Saarinen KM, Juntunen-Backman K, Järvenpää AL, Klemetti P, Kuitunen P, Lope L, et al. Breast-feeding and the development of cow’s milk protein allergy. Adv Exp Med Biol. 2000;478:121–130
  34. Jang N, Stewart G, Jones G. Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis. Genes Immunol. 2005;6:262–264
  35. Novak N, Bieber T, Leung DY. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003;112:S128–S139
  36. Sicherer SH, Sampson HA. Food hypersensitivity and atopic dermatitis: pathophysiology, epidemiology, diagnosis, and management. J Allergy Clin Immunol. 1999;104:S114–S122
  37. Abernathy-Carver KJ, Sampson HA, Picker LJ, Leung DY. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest. 1995;95:913–918
  38. van Reijsen FC, Felius A, Wauters EA, Bruijnzeel-Koomen CA, Koppelman SJ. T-cell reactivity for a peanut-derived epitope in the skin of a young infant with atopic dermatitis. J Allergy Clin Immunol. 1998;101:207–209
  39. Li XM, Kleiner G, Huang CK, Lee SY, Schofield B, Soter NA, et al. Murine model of atopic dermatitis associated with food hypersensitivity. J Allergy Clin Immunol. 2001;107:693–702
  40. Sampson HA. Food sensitivity and the pathogenesis of atopic dermatitis. J R Soc Med. 1997;90(Suppl 30):2–8
  41. Zeiger RS, Heller S, Mellon MH, Forsythe AB, O’Connor RD, Hamburger RN, et al. Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study. J Allergy Clin Immunol. 1989;84:72–89
  42. Arshad SH, Matthews S, Gant C, Hide DW. Effect of allergen avoidance on development of allergic disorders in infancy. Lancet. 1992;339:1493–1497

PII: S0022-3476(07)00446-5

doi: 10.1016/j.jpeds.2007.04.070

The Journal of Pediatrics
Volume 151, Issue 4 , Pages 359-363 , October 2007

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