IgE Food Sensitization in Infants with Eczema Attending a Dermatology Department
Received 2 October 2006; received in revised form 13 February 2007; accepted 27 April 2007. published online 07 August 2007.
Refers to article:
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Objectives
Because community-based studies, which report IgE food sensitization (IgE-FS) in more than 80% of infants with moderate atopic eczema, may be influenced by referral bias, we assessed the prevalence of IgE-FS in a cohort of infants with moderate atopic eczema attending a dermatology department clinic.
Study design
Consecutive infants (n = 51, 39 males; median age, 34 weeks; range, 20 to 51 weeks) with moderate atopic eczema referred to a university-affiliated dermatology department were studied prospectively. Clinical history and eczema severity were documented. IgE-FS was assessed by the skin prick test (SPT; n = 51) and food-specific serum IgE antibodies (CAP-FEIA test; n = 41). IgE-FS was diagnosed if the SPT or CAP-FEIA level exceeded the >95% predictive reference cutoff for positive food challenges.
Results
Based on SPT, 44 of 51 infants (86%; 95% confidence interval [CI] = 74% to 94%) had IgE-FS (cow’s milk, 16%; egg, 73%; peanut, 51%). Using age-specific 95%-predictive cutoff values, CAP-FEIA identified 34 of 41 infants (83%; 95% CI = 68% to 93%) with IgE-FS (cow’s milk, 23%; egg, 80%). Forty-six (90%) infants had IgE-FS to at least 1 food item by either SPT or CAP-FEIA.
Conclusions
Atopic eczema was found to be closely associated with IgE-FS in infants attending a dermatology department.
aDepartment of Allergy & Immunology, Royal Children’s Hospital, Melbourne, Australia
bDepartment of Dermatology, Royal Children’s Hospital, Melbourne, Australia
cClinical Epidemiology and Biostatistics Unit, Royal Children’s Hospital, Melbourne, Australia
dMurdoch Children’s Research Institute, Melbourne, Australia
eDepartment of Paediatrics, University of Melbourne, Melbourne, Australia.
Reprint requests: David Hill, FRACP, Senior Consultant Allergist, Murdoch Children’s Research Institute, Royal Children’s Hospital, Flemington Road, Parkville, Vic 3052, Australia.
ABSTRACT