The Journal of Pediatrics
Volume 151, Issue 6 , Pages 675-678 , December 2007

Prevalence of the MEFV Gene Mutations in Childhood Polyarteritis Nodosa

  • Fatoş Yalçınkaya, MD

      Affiliations

    • Ankara University School of Medicine, Division of Pediatric Nephrology, Ankara, Turkey
    • Corresponding Author InformationReprint requests: Dr Fatoş Yalçınkaya, Çınar Sitesi 5 Blok No: 62, Ümitköy 06530, Ankara, Turkey.
    • ,
  • Z. Bı̇rsı̇n Özçakar, MD

      Affiliations

    • Ankara University School of Medicine, Division of Pediatric Nephrology, Ankara, Turkey
    • ,
  • Özgür Kasapçopur, MD

      Affiliations

    • Istanbul University Cerrahpaşa Medical School, Division of Pediatric Nephrology-Rheumatology, Ankara, Turkey
    • ,
  • Ayşenur Öztürk, MSc

      Affiliations

    • Ankara University School of Medicine, Division of Pediatric Genetics, Ankara, Turkey
    • ,
  • Nejat Akar, MD

      Affiliations

    • Ankara University School of Medicine, Division of Pediatric Genetics, Ankara, Turkey
    • ,
  • Ayşı̇n Bakkaloğlu, MD

      Affiliations

    • Hacettepe University School of Medicine, Division of Pediatric Nephrology-Rheumatology, Ankara, Turkey.
    • ,
  • Nı̇l Arısoy, MD

      Affiliations

    • Istanbul University Cerrahpaşa Medical School, Division of Pediatric Nephrology-Rheumatology, Ankara, Turkey
    • ,
  • Mesı̇ha Ekı̇m, MD

      Affiliations

    • Ankara University School of Medicine, Division of Pediatric Nephrology, Ankara, Turkey
    • ,
  • Seza Özen, MD

      Affiliations

    • Hacettepe University School of Medicine, Division of Pediatric Nephrology-Rheumatology, Ankara, Turkey.

Received 17 December 2006 ,Revised 12 March 2007 ,Accepted 25 April 2007.

References 

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  10. Samuels J, Aksentijevich I, Torosyan Y, Centola M, Deng Z, Sood R, et al. Familial Mediterranean fever at the millennium (Clinical spectrum, ancient mutations and a survey of 100 American referrals to the National Institute of Health). Medicine (Baltimore). 1998;77:268–297
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  12. Ben-Chetrit E, Lerer I, Malamud E, Domingo C, Abeliovich D. The E148Q mutation in the MEFV gene: is it a disease-causing mutation or a sequence variant?. Hum Mutat. 2000;15:385–386
  13. Topaloglu R, Özaltın F, Yılmaz E, Özen S, Balcı B, Beşbaş N, et al. E148Q is a disese-causing mutation MEFV mutation: a phenotypic evaluation in patients with familial Mediterranean fever. Ann Rheum Dis. 2005;64:750–752
  14. Guillevin L, Lhote F, Cohen P, Sauvaget F, Jarrousse B, Lortholary O, et al. Polyarteritis nodosa related to hepatitis B virus: a prospective study with long term observations of 41 patients. Medicine. 1995;74:238–254
  15. Falk RJ, Nachman PH, Hogan SL, Jennette JC. ANCA glomerulonephritis and vasculitis: a Chapel Hill perspective. Semin Nephrol. 2000;20:233–243
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  17. Gershoni-Baruch R, Broza Y, Brik R. Prevalence and significance of mutations in the Familial Mediterranean fever gene in Henoch-Schönlein purpura. J Pediatr. 2003;143:658–661
  18. Tutar E, Akar N, Atalay S, Yılmaz E, Akar E, Yalçınkaya F. Familial Mediterranean fever gene (MEFV) mutations in patients with rheumatic heart disease. Heart. 2002;87:568–569
  19. Atagündüz P, Ergün T, Direskeneli H. MEFV mutations are increased in Behçet’s disease (BD) and are associated with vascular involvement. Clin Exp Rheumatol. 2003;21:35–37
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  21. Lachmann HJ, Şengül B, Yavuzşen TU, Booth DR, Booth SE, Bybee A, et al. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatol. 2006;45:746–750
  22. Yalçınkaya F, İnce E, Uçar T, Ozkaya N, Tekin M, Elhan E, et al. Antistreptococcal response is exaggerated in children with familial Mediterranean fever. Clin Rheumatol. 2002;21:378–381

PII: S0022-3476(07)00439-8

doi: 10.1016/j.jpeds.2007.04.062

The Journal of Pediatrics
Volume 151, Issue 6 , Pages 675-678 , December 2007

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