The Journal of Pediatrics
Volume 150, Issue 6 , Pages 575-577 , June 2007

Brain Imaging in Neonatal Clinical Trials: In Search of a Gold Standard

  • Yvonne E. Vaucher, MD, MPH

      Affiliations

    • Division of Neonatal/Perinatal Medicine, Department of Pediatrics, University of California, San Diego, San Diego, California
    • Corresponding Author InformationReprint requests: Yvonne E, Vaucher, MD, MPH, Division of Neonatal/Perinatal Medicine, UCSD Medical Center MC-8774, 200 W Arbor Dr, San Diego, CA 92103-8774.
    • ,
  • Dolores H. Pretorius, MD

      Affiliations

    • Division of Body Imaging, Department of Radiology, University of California, San Diego, San Diego, California

References 

  1. Hintz SR, Slovis T, Bulas D, Van Meurs KP, Perritt R, Stevenson DK, et al. Interobserver reliability and accuracy of cranial ultrasound interpretation in premature infants. J Pediatr. 2007;150:592–596
  2. Harris DL, Bloomfield FH, Teele RL, Harding JE, et al. Does variation in interpretation of ultrasonograms account for the variation in the incidence of germinal matrix/intraventricular haemorrhage between newborn intensive care units in New Zealand?. Arch Dis Child Fetal Neonatal Ed. 2005;90:F494–F499
  3. Harris DL, Bloomfield FH, Teele RL, Harding JE, et al. Variable interpretation of ultrasonograms may contribute to variation in the reported incidence of white matter damage between newborn intensive care units in New Zealand. Arch Dis Child Fetal Neonatal Ed. 2006;91:F11–F16
  4. Fawer CL, Calame A, Furrer MT. Neurodevelopmental outcome at 12 months of age related to cerebral ultrasound appearances of high-risk preterm infants. Early Hum Dev. 1985;11:1230132
  5. Vohr BR, Garcia-Coll C, Mayfield S, Brann B, Shaul P, Oh W. Neurologic and developmental status related to the evolution of visual-motor abnormalities from birth to 2 years of age in preterm infants with intraventricular hemorrhage. J Pediatr. 1989;115:296–302
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  7. Patra K, Wilson-Costello D, Taylor HG, Mercuri-Minich N, Hack M. Grades I-II intraventricular hemorrhage in extremely low birthweight infants: effects on neurodevelopment. J Pediatr. 2006;149:152–154
  8. Hüppi PS, Murphy B, Maier SE, Zientara GP, Inder TE, Barnes PD, et al. Microstructural brain development after perinatal cerebral white matter injury assessed by diffusion tensor magnetic resonance imaging. Pediatrics. 2001;107:455–460
  9. Counsell SJ, Shen Y, Boardman JP, Larkman DJ, Kapellou O, Ward P, et al. Axial and radial diffusivity in preterm infants who have diffuse white matter changes on magnetic resonance imaging at term-equivalent age. Pediatrics. 2006;117:376–386
  10. Vasileiadis GT, Gelman N, Han VKM, Williams L, Mann R, Bureau Y, et al. Uncomplicated intraventricular hemorrhage is followed by reduced cortical volume at near-term age. Pediatrics. 2004;114:e367–e372
  11. Woodward LJ, Anderson PJ, Austin NC, Howard K, Inder TE. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. N Engl J Med. 2006;355:685–694
  12. Dyet LE, Kennea N, Counsell SJ, Maalouf EF, Ajayi-Obe M, Duggan PJ. Natural history of brain lesions in extremely preterm infants studied with serial magnetic resonance imaging from birth and neurodevelopmental assessment. Pediatrics. 2006;118:536–548
  13. Inder TE, Well SJ, Mogridge NB, Spencer C, Volpe JJ. Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr. 2003;143:171–179
  14. Rademaker KJ, Uiterwaal CS, Beek FJA, van Haastert IC, Lieftink AF, Groenendaal F, et al. Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age in children born preterm. Arch Dis Child Fetal Neonatal Ed. 2005;90:F489–F493
  15. Maalouf EF, Duggan PJ, Counsell SJ, Rutherford MA, Cowan F, Azzopardi D, et al. Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants. Pediatrics. 2001;107:719–727
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  17. Berlin L, Berlin JW. Malpractice and radiologists in Cook County, Il: trends in 20 years of litigation. AJR. 1995;165:781–788
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PII: S0022-3476(07)00332-0

doi: 10.1016/j.jpeds.2007.04.002

The Journal of Pediatrics
Volume 150, Issue 6 , Pages 575-577 , June 2007

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