The Journal of Pediatrics
Volume 151, Issue 3 , Pages 255-259, September 2007

Primary Sclerosing Cholangitis in Childhood is Associated with Abnormalities in Cystic Fibrosis–Mediated Chloride Channel Function

  • Harpreet Pall, MD

      Affiliations

    • Division of Pediatric Gastroenterology, Children’s Hospital Boston, Harvard Medical School, Boston, MA
    • Corresponding Author InformationReprint requests: Dr Harpreet Pall, Children’s Hospital Boston, Division of Gastroenterology, 300 Longwood Avenue, Boston, MA 02115.
    • ,
  • Julian Zielenski, PhD

      Affiliations

    • Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Maureen M. Jonas, MD

      Affiliations

    • Division of Pediatric Gastroenterology, Children’s Hospital Boston, Harvard Medical School, Boston, MA
    • ,
  • Deborah A. DaSilva, RN

      Affiliations

    • Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
    • ,
  • Kimberly M. Potvin

      Affiliations

    • Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
    • ,
  • Xiao-Wei Yuan, MSc

      Affiliations

    • Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Qiuju Huang, MD

      Affiliations

    • Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Steven D. Freedman, MD, PhD

      Affiliations

    • Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Received 5 November 2006; received in revised form 12 February 2007; accepted 30 March 2007. published online 28 July 2007.

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 Supported by the Thrasher Research Fund (grant 02820-4) and The General Clinical Research Centers at Children’s Hospital Boston (NIH M01 RR02172) and The Beth Israel Deaconess Medical Center (NIH M01 RR01032). Dr Pall was supported in part by the Harvard/MIT Clinical Investigator Training Program. This project was also partially funded by Genome Canada through the Ontario Genomics Institute as per research agreement 2004-OGI-3-05. The study sponsors did not have a role in the study design, data analysis, or preparation of the manuscript.

PII: S0022-3476(07)00330-7

doi:10.1016/j.jpeds.2007.03.062

Refers to article:

  • What is the Role of Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Primary Sclerosing Cholangitis?

    Dennis D. Black
    The Journal of Pediatrics September 2007 (Vol. 151, Issue 3, Pages 230-232)

The Journal of Pediatrics
Volume 151, Issue 3 , Pages 255-259, September 2007

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