The Journal of Pediatrics
Volume 151, Issue 4 , Pages 409-413.e2 , October 2007

Perinatal Stroke and the Risk of Developing Childhood Epilepsy

  • Meredith R. Golomb, MD, MSc

      Affiliations

    • Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana
    • Dr Golomb is supported by the National Institutes of Health NINDS grant K23 NS048024 and the Clarian Values Fund grant VFR-171.
    • Corresponding Author InformationReprint requests: Dr Meredith Golomb, MD, MSc, Indiana University School of Medicine, Building XE, Room 040 (Pediatric Neurology), 575 West Dr., Indianapolis, IN 46202.
    • ,
  • Bhuwan P. Garg, MBBS

      Affiliations

    • Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana
    • ,
  • Karen S. Carvalho, MD

      Affiliations

    • Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana
    • ,
  • Cynthia S. Johnson, MAc

      Affiliations

    • Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana
    • ,
  • Linda S. Williams, MD

      Affiliations

    • Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana
    • Roudebush VAMC, Indiana University School of Medicine, Indianapolis, Indiana
    • The Regenstrief Institute, Indiana University School of Medicine, Indianapolis, Indiana.
    • Dr Williams is supported by the National Institutes of Health NINDS R01 NS 39571 and a VA Health Services Research and Development Career Award.

Received 23 August 2006 ,Revised 1 February 2007 ,Accepted 26 March 2007.

References 

  1. Cowan LD. The epidemiology of the epilepsies in children. Ment Retard Dev Disabil Res Rev. 2002;8:171–181
  2. Sran SK, Baumann RJ. Outcome of neonatal strokes. Am J Dis Child. 1988;142:1086–1088
  3. Sreenan C, Bhargava R, Robertson CM. Cerebral infarction in the term newborn: clinical presentation and long-term outcome. J Pediatr. 2000;137:351–355
  4. Estan J, Hope P. Unilateral neonatal cerebral infarction in full term infants. Arch Dis Child Fetal Neonatal Ed. 1997;76:F88–F93
  5. Koelfen W, Freund M, Varnholt V. Neonatal stroke involving the middle cerebral artery in term infants: clinical presentation, EEG and imaging studies, and outcome. Dev Med Child Neurol. 1995;37:204–212
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  15. Golomb MR, Garg BP, Williams LS. Outcomes of children with infantile spasms after perinatal stroke. Pediatr Neurol. 2006;34:291–295
  16. Carlsson M, Hagberg G, Olsson I. Clinical and aetiological aspects of epilepsy in children with cerebral palsy. Dev Med Child Neurol. 2003;45:371–376
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  18. Bruck I, Antoniuk SA, Spessatto A, Bem RS, Hausberger R, Pacheco CG. Epilepsy in children with cerebral palsy. Arq Neuropsiquiatr. 2001;59:35–39
  19. Uvebrant P. Hemiplegic cerebral palsy (Aetiology and outcome). Acta Paediatr Scand Suppl. 1988;345:1–100
  20. Humphreys P, Whiting S, Pham B. Hemiparetic cerebral palsy: clinical pattern and imaging in prediction of outcome. Can J Neurol Sci. 2000;27:210–219
  21. Ozduman K, Pober BR, Barnes P, Copel JA, Ogle EA, Duncan CC, et al. Fetal stroke. Pediatr Neurol. 2004;30:151–162
  22. deVeber GA, MacGregor D, Curtis R, Mayank S. Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol. 2000;15:316–324

PII: S0022-3476(07)00326-5

doi: 10.1016/j.jpeds.2007.03.058

The Journal of Pediatrics
Volume 151, Issue 4 , Pages 409-413.e2 , October 2007

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