The Journal of Pediatrics
Volume 151, Issue 3 , Pages 239-243, September 2007

Subclinical Atherosclerosis, but Normal Autonomic Function after Kawasaki Disease

  • Robert Dalla Pozza, MD

      Affiliations

    • Department of Pediatric Cardiology, University Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany
    • Corresponding Author InformationReprint requests: Dr R. Dalla Pozza, Department of Pediatric Cardiology, University Children’s Hospital, Ludwig-Maximilians-University, Lindwurmstr. 4, 80336 Munich, Germany.
    • ,
  • Susanne Bechtold, MD

      Affiliations

    • Division of Pediatric Rheumatology, University Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany.
    • ,
  • Simon Urschel, MD

      Affiliations

    • Department of Pediatric Cardiology, University Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Rainer Kozlik-Feldmann, MD

      Affiliations

    • Department of Pediatric Cardiology, University Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Heinrich Netz, MD, PhD

      Affiliations

    • Department of Pediatric Cardiology, University Children’s Hospital, Ludwig-Maximilians-University, Munich, Germany

Received 7 November 2006; received in revised form 29 December 2006; accepted 22 March 2007. published online 28 July 2007.

Objective

To compare the carotid artery intima-media-thickness (IMT) of children with Kawasaki disease with normative data for Western children.

Study design

Forty-eight children (20 patients after Kawasaki disease, mean age 12.1 ± 4.7 years; 28 age- and sex-matched healthy controls, mean age 12.0 ± 3.1 years) were studied.

Results

Mean (IMT differed significantly (0.449 ± 0.02 vs 0.424 ± 0.01, P < .001) as well as IMT standard deviation score (1.2 ± 0.6 vs 0.3 ± 0.1, P < .001). Patients with coronary arterial involvement (n = 15) showed a further increase of the IMT (0.459 ± 0.01 vs 0.436 ± 0.01, P < .05). There was no difference regarding short-term blood pressure regulation.

Conclusions

In this small patient group, signs of subclinical atherosclerosis after Kawasaki disease have been detected. These preliminary data indicate that these patients may be at risk for cardiovascular disease even in the absence of permanent alterations of the coronary arteries.

Abbreviations: BMI, Body mass index, BRS, Baroreceptor sensitivity, CRP, C-reactive protein, ESR, Erythrocyte sedimentation rate, HDL, High-density lipoprotein cholesterol, IMT, Intima-media thickness, LDL, Low-density lipoprotein cholesterol, WBC, White blood cell count

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PII: S0022-3476(07)00294-6

doi:10.1016/j.jpeds.2007.03.057

Refers to article:

  • Are Patients with Kawasaki Disease at Risk for Premature Atherosclerosis?

    Elif Seda Selamet Tierney, Jane W. Newburger
    The Journal of Pediatrics September 2007 (Vol. 151, Issue 3, Pages 225-228)

  • Are Patients after Kawasaki Disease at Increased Risk for Accelerated Atherosclerosis? , 28 July 2007

    Brian W. McCrindle, Susan McIntyre, Christopher Kim, Tammy Lin, Khosrow Adeli
    The Journal of Pediatrics September 2007 (Vol. 151, Issue 3, Pages 244-248.e1)

The Journal of Pediatrics
Volume 151, Issue 3 , Pages 239-243, September 2007

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