The Journal of Pediatrics
Volume 151, Issue 1 , Pages 3-4 , July 2007

Iron Supplementation in Prematurity: How Much is Too Much?

  • Pamela J. Kling, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Dr Pamela J. Kling, University of Wisconsin and Meriter Hospital, Pediatrics/Division of Neonatology 6 Center, 202 S Park St, Madison, WI 53715.

References 

  1. Brække K, Bechensteen AG, Blomhoff R, Haaland K, Staff AC. Oxidative stress markers and antioxidant status following oral iron supplementation to very low birth weight infants. J Pediatr. 2007;151:23–28
  2. Bechensteen AG, Håga P, Halvorsen S, Whitelaw A, Liestøl K, Lindemann R, et al. Erythropoietin, protein, and iron supplementation and the prevention of anaemia of prematurity. Arch Dis Child. 1993;69:19–23
  3. AAP. Iron Deficiency. In: American Academy of Pediatrics, editor (Pediatric Nutrition Handbook). 5th ed.. Chicago, IL: American Academy of Pediatrics; 2004;p. 299–312
  4. Siddappa AJM, Rao RB, Wobken JD, Leibold EA, Connor JR, Georgieff MK. Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J Neurosci Res. 2002;68:761–765
  5. Williams ML, Shoot RJ, O’Neal PA, Oski FA. Role of dietary iron and fat on vitamin E deficiency anemia of infancy. N Engl J Med. 1975;292:887–890
  6. Strauss RG. Transfusion therapy in neonates. Am J Dis Child. 1991;145:904–911
  7. Kling PJ, Sullivan TM, Leftwich ME, Roe DJ. Score for neonatal acute physiology predicts erythrocyte transfusions in premature infants. Arch Dis Pediatr Adolesc Med. 1997;151:27–31
  8. Widness JA, Seward VJ, Kromer IJ, Burmeister LF, Bell EF, Strauss RG. Changing patterns of red blood cell transfusion in very low birth weight infants. J Pediatr. 1996;129:680–687
  9. Lozoff B, Georgieff MK. Iron deficiency and brain development. Sem Pediatr Neurol. 2006;13:158–165
  10. Friel JK, Aziz K, Andrews WL, Serfass RE. Iron absorption and oxidant stress during erythropoietin therapy in very low birth weight premature infants: a cohort study. BMC Pediatrics. 2005;5(29):[serial on the internet]. Aug [6p]. Available from: http://www.biomedcentral.com/1471-2431/5/29.
  11. Pollak A, Hayde M, Hayn M, Herkner K, Lombard KA, Lubec G, et al. Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants. Pediatrics. 2001;107:78–85
  12. Miller SM, McPherson RJ, Juul SE. Iron sulfate supplementation decreases zinc protoporphyrin to heme ratio in premature infants. J Pediatr. 2006;148:44–48
  13. Dani C, Martelli E, Bertini G, Pezzati M, Rossetti M, Buonocore G, et al. Effect of blood transfusions on oxidative stress in preterm infants. Arch Dis Child. 2004;89:F408–F411

PII: S0022-3476(07)00266-1

doi: 10.1016/j.jpeds.2007.03.041

The Journal of Pediatrics
Volume 151, Issue 1 , Pages 3-4 , July 2007

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