The Journal of Pediatrics
Volume 150, Issue 6 , Pages 654-655, June 2007

Treatment of Chronic Fatigue and Orthostatic Intolerance with Propranolol

  • Vegard Bruun Wyller, MD

      Affiliations

    • Department of Pediatrics, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway
    • Department of Physiology, University of Oslo, Oslo, Norway
    • Corresponding Author InformationReprint requests: Vegard Bruun Wyller, Dept of Paediatrics, Rikshospitalet-Radiumhospitalet Medical Centre, N-0027 Oslo, Norway.
    • ,
  • Erik Thaulow, MD, PhD

      Affiliations

    • Department of Pediatrics, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway
    • ,
  • Jan P. Amlie, MD, PhD

      Affiliations

    • Medical Outpatient Clinic, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway.

Received 7 November 2006; received in revised form 9 January 2007; accepted 7 March 2007.

We describe the effect of propranolol in an adolescent with chronic fatigue syndrome and orthostatic intolerance. Our observations suggest that the head-up tilt-test and beta-blocker treatment might be considered in patients with chronic fatigue syndrome and that enhanced sympathetic nervous activity might be part of the underlying pathophysiology.

Abbreviations: BP, Blood pressure, CFS, Chronic fatigue syndrome, HUT, Head-up tilt-test, HR, Heart rate, POTS, Postural orthostatic tachycardia syndrome

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PII: S0022-3476(07)00252-1

doi:10.1016/j.jpeds.2007.03.012

The Journal of Pediatrics
Volume 150, Issue 6 , Pages 654-655, June 2007

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