The Journal of Pediatrics
Volume 151, Issue 3 , Pages 289-292 , September 2007

A Randomized, Controlled Trial of Tonsillectomy in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome

  • M. Renko, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Oulu, Finland
    • Corresponding Author InformationReprint requests: Marjo Renko, MD, PhD, Department of Pediatrics, University of Oulu, Box 5000, FIN-90014 University of Oulu, Finland.
    • ,
  • E. Salo, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Helsinki, Finland
    • ,
  • A. Putto-Laurila, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Turku, Finland.
    • ,
  • H. Saxen, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Helsinki, Finland
    • ,
  • P.S. Mattila, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, University of Helsinki, Finland
    • ,
  • J. Luotonen, MD, PhD

      Affiliations

    • Department of Otorhinolaryngology, University of Oulu, Finland
    • ,
  • O. Ruuskanen, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Turku, Finland.
    • ,
  • M. Uhari, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Oulu, Finland

Received 17 October 2006 ,Revised 29 December 2006 ,Accepted 6 March 2007.

References 

  1. Marshall GS, Edwards KM, Butler J, Lawton AR. Syndrome of periodic fever, pharyngitis, and aphthous stomatitis. J Pediatr. 1987;110:43–46
  2. Galanakis E, Papadakis CE, Giannoussi E, Karatzanis AD, Bitsori M, Helidonis ES. PFAPA syndrome in children evaluated for tonsillectomy. Arch Dis Child. 2002;86:434–435
  3. Thomas KT, Feder HM, Lawton AR, Edwards KM. Periodic fever syndrome in children. J Pediatr. 1999;135:15–21
  4. Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P, et al. Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr. 1999;135:98–101
  5. John CC, Gilsdorf JR. Recurrent fever in children. Pediatr Infect Dis J. 2002;21:1071–1077
  6. Drenth JP, van der Meer JW. Hereditary periodic fever. N Engl J Med. 2001;345:1748–1757
  7. Long SS. Distinguishing among prolonged, recurrent, and periodic fever syndromes: approach of a pediatric infectious diseases subspecialist. Pediatr Clin North Am. 2005;52:811–835
  8. Bakkaloglu A. Familial Mediterranean fever. Pediatr Nephrol. 2003;18:853–859
  9. Feder HM. Cimetidine treatment for periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. Pediatr Infect Dis J. 1992;11:318–321
  10. Dahn KA, Glode MP, Chan KH. Periodic fever and pharyngitis in young children: a new disease for the otolaryngologist?. Arch Otolaryngol Head Neck Surg. 2000;126:1146–1149
  11. Tasher D, Somekh E, Dalal I. PFAPA syndrome: new clinical aspects disclosed. Arch Dis Child. 2006;91:981–984

PII: S0022-3476(07)00251-X

doi: 10.1016/j.jpeds.2007.03.015

The Journal of Pediatrics
Volume 151, Issue 3 , Pages 289-292 , September 2007

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