The Journal of Pediatrics
Volume 151, Issue 2 , Pages 187-191 , August 2007

Aeroallergen Sensitization in Healthy Children: Racial and Socioeconomic Correlates

  • Michelle D. Stevenson, MD, MS

      Affiliations

    • Division of Emergency Medicine, Akron Children’s Hospital and Northeastern Ohio Universities College of Medicine, Akron, Ohio
    • Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
    • Dr. Michelle Stevenson authored the first draft of this manuscript and did not receive any form of payment to produce this manuscript.
    • Corresponding Author InformationReprint requests: Dr Michelle D. Stevenson, Division of Emergency Medicine, Akron Children’s Hospital, One Perkins Square, Akron, OH 44308.
    • ,
  • Stacey Sellins, MMS

      Affiliations

    • Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Emilie Grube, BA

      Affiliations

    • Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Kathy Schroer, BS

      Affiliations

    • Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Jayanta Gupta, MD

      Affiliations

    • Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
    • ,
  • Ning Wang, PhD

      Affiliations

    • Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Gurjit K. Khurana Hershey, MD, PhD

      Affiliations

    • Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

Received 30 May 2006 ,Revised 5 December 2006 ,Accepted 1 March 2007.

References 

  1. Expert Panel, Report 2. Guidelines for the Diagnosis and Management of Asthma; NIH Publication No. 97-4051. NIH, NHLBI 1997.
  2. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life: the Group Health Medical Associates. N Engl J Med. 1995;332:133–138
  3. Kurukulaaratchy RJ, Matthews S, Arshad SH. Does environment mediate earlier onset of the persistent childhood asthma phenotype?. Pediatrics. 2004;113:345–350
  4. Illi S, von Mutius E, Lau S, Nickel R, Niggemann B, Sommerfeld C, et al. The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol. 2001;108:709–714
  5. Smart JM, Tang ML, Kemp AS. Polyclonal and allergen-induced cytokine responses in children with elevated immunoglobulin E but no atopic disease. Clin Exp Allergy. 2002;32:1552–1557
  6. Bloom B, Dey AN. Summary health statistics for US children: National Health Interview Survey, 2004. Vital Health Stat 10 2006:1-85.
  7. Sarpong SB, Hamilton RG, Eggleston PA, Adkinson NF. Socioeconomic status and race as risk factors for cockroach allergen exposure and sensitization in children with asthma. J Allergy Clin Immunol. 1996;97:1393–1401
  8. Crockcroft DW, Murdock KY, Berscheid BA. Relationship between atopy and bronchial responsiveness to histamine in a random population. Ann Allergy. 1984;53:26–29
  9. Sears MR, Burrows B, Herbison GP, Holdaway MD, Flannery EM. Atopy in childhood, II: relationship to airway responsiveness, hay fever and asthma. Clin Exp Allergy. 1993;23:949–956
  10. Steinman HA, Donson H, Kawalski M, Toerien A, Potter PC. Bronchial hyper-responsiveness and atopy in urban, peri-urban and rural South African children. Pediatr Allergy Immunol. 2003;14:383–393
  11. de Gooijer A, Brand PL, Gerritsen J, Koeter GH, Postma DS, Knol K. Changes in respiratory symptoms and airway hyperresponsiveness after 27 years in a population-based sample of school children. Eur Respir J. 1993;6:848–854
  12. van Amsterdam JG, Bischoff EW, Hady M, Opperhuizen A, Steerenberg PA. The prevalence of allergic sensitisation in immigrant children in The Netherlands. Int Arch Allergy Immunol. 2004;133:248–254
  13. Roberts G, Hurley C, Lack G. Development of a quality-of-life assessment for the allergic child or teenager with multisystem allergic disease. J Allergy Clin Immunol. 2003;111:491–497
  14. Roberts G, Mylonopoulou M, Hurley C, Lack G. Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation. Clin Exp Allergy. 2005;35:1295–1300
  15. Boulet LP, Turcotte H, Laprise C, Lavertu C, Bedard PM, Lavoie A, et al. Comparative degree and type of sensitization to common indoor and outdoor allergens in subjects with allergic rhinitis and/or asthma. Clin Exp Allergy. 1997;27:52–59
  16. Gergen PJ, Turkeltaub PC, Kovar MG. The prevalence of allergic skin test reactivity to eight common aeroallergens in the US population: results from the second National Health and Nutrition Examination Survey. J Allergy Clin Immunol. 1987;80:669–679
  17. Arbes SJ, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol. 2005;116:377–383
  18. Stevenson LA, Gergen PJ, Hoover DR, Rosenstreich D, Mannino DM, Matte TD. Sociodemographic correlates of indoor allergen sensitivity among United States children. J Allergy Clin Immunol. 2001;108:747–752
  19. Meltzer EO. Allergic rhinitis: managing the pediatric spectrum. Allergy Asthma Proc. 2006;27:2–8
  20. Lester LA, Rich SS, Blumenthal MN, Togias A, Murphy S, Malveaux F, et al. Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma. J Allergy Clin Immunol. 2001;108:357–362
  21. Celedon JC, Sredl D, Weiss ST, Pisarski M, Wakefield D, Cloutier M. Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut. Chest. 2004;125:85–92
  22. Joseph CL, Ownby DR, Peterson EL, Johnson CC. Racial differences in physiologic parameters related to asthma among middle-class children. Chest. 2000;117:1336–1344
  23. Settipane RJ, Hagy GW, Settipane GA. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc. 1994;15:21–25

 Supported by National Institutes of Health grant R01AI46652-01A1 (G.K.K.H.), University of Cincinnati, Molecular Epidemiology in Children’s Environmental Health, Institutional NIEHS T32 ES10957 (M.D.S.); and Cincinnati Children’s Hospital Medical Center, Institutional NICHD T32 HD43005 (M.D.S.).

PII: S0022-3476(07)00237-5

doi: 10.1016/j.jpeds.2007.03.001

The Journal of Pediatrics
Volume 151, Issue 2 , Pages 187-191 , August 2007

Article Tools

* Image Usage & Resolution