The Journal of Pediatrics
Volume 151, Issue 1 , Pages 29-33 , July 2007

Transient Tachypnea of the Newborn May Be an Early Clinical Manifestation of Wheezing Symptoms

  • Joel J. Liem, MD, FRCPC

      Affiliations

    • From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  • ,
  • Shamima I. Huq, BSc

      Affiliations

    • Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.
  • ,
  • Okechukwu Ekuma, MSc

      Affiliations

    • Manitoba Centre for Health Policy, Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
  • ,
  • Allan B. Becker, MD, FRCPC

      Affiliations

    • From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  • ,
  • Anita L. Kozyrskyj, PhD

      Affiliations

    • From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    • Manitoba Centre for Health Policy, Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    • Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.
    • Corresponding Author InformationReprint requests: Anita L. Kozyrskyj, PhD, Faculty of Pharmacy, Rm 210 Pharmacy Bldg, University of Manitoba, Winnipeg, Manitoba, Canada R3PT 2N2.

Received 13 March 2006 ,Revised 12 December 2006 ,Accepted 5 February 2007.

References 

  1. Avery ME, Gatewood OB, Brumley G. Transient tachypnea of newborn (Possible delayed resorption of fluid at birth). Am J Dis Child. 1966;111:380–385
  2. Brice JE, Walker CH. Changing pattern of respiratory distress in newborn. Lancet. 1977;2:752–754
  3. Rimmer S, Fawcitt J. Delayed clearance of pulmonary fluid in the neonate. Arch Dis Child. 1982;57:63–67
  4. Tudehope DI, Smyth MH. Is “transient tachypnoea of the newborn” always a benign disease? (Report of 6 babies requiring mechanical ventilation). Aust Paediatr J. 1979;15:160–165
  5. Halliday HL, McClure G, Reid MM. Transient tachypnoea of the newborn: two distinct clinical entities?. Arch Dis Child. 1981;56:322–325
  6. Bucciarelli RL, Egan EA, Gessner IH, Eitzman DV. Persistence of fetal cardiopulmonary circulation: one manifestation of transient tachypnea of the newborn. Pediatrics. 1976;58:192–197
  7. Miller LK, Calenoff L, Boehm JJ, Riedy MJ. Respiratory distress in the newborn. JAMA. 1980;243:1176–1179
  8. Subramanian KN. Transient Tachypnea of the Newborn, e-Medicine, November 21, 2006; http://www.emedicine.com/ped/topic2597.htm.
  9. Gross TL, Sokol RJ, Kwong MS, Wilson M, Kuhnert PM. Transient tachypnea of the newborn: the relationship to preterm delivery and significant neonatal morbidity. Am J Obstet Gynecol. 1983;146:236–241
  10. Rawlings JS, Smith FR. Transient tachypnea of the newborn (An analysis of neonatal and obstetric risk factors). Am J Dis Child. 1984;138:869–871
  11. Barker PM, Olver RE. Invited review: clearance of lung liquid during the perinatal period. J Appl Physiol. 2002;93:1542–1548
  12. Olver RE, Walters DV, Wilson M. Developmental regulation of lung liquid transport. Annu Rev Physiol. 2004;66:77–101
  13. O’Brodovich HM. Immature epithelial Na+ channel expression is one of the pathogenetic mechanisms leading to human neonatal respiratory distress syndrome. Proc Assoc Am Physicians. 1996;108:345–355
  14. Brown MJ, Olver RE, Ramsden CA, Strang LB, Walters DV. Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol. 1983;344:137–152
  15. Chapman DL, Carlton DP, Cummings JJ, Poulain FR, Bland RD. Intrapulmonary terbutaline and aminophylline decrease lung liquid in fetal lambs. Pediatr Res. 1991;29:357–361
  16. Lagercrantz H, Bistoletti P. Catecholamine release in the newborn infant at birth. Pediatr Res. 1977;11:889–893
  17. Robinson JR, Young TK, Roos LL, Gelskey DE. Estimating the burden of disease (Comparing administrative data and self-reports). Med Care. 1997;35:932–947
  18. Kozyrskyj AL, Mustard CA. Validation of an electronic, population-based prescription database. Ann Pharmacother. 1998;32:1152–1157
  19. Therneau T, Grambsch P. Modeling Survival Data: Extending the Cox Model. New York: Springer-Verlag; 2000;
  20. Schoenfeld D. Partial Residuals for the Proportional Hazards Regression Model. 1982;69:239–241
  21. SAS Institute. SAS User’s Guide, Version 9.1 for Unix. Cary, NC: SAS Institute; 2006;
  22. Smith GC, Wood AM, White IR, Pell JP, Cameron AD, Dobbie R. Neonatal respiratory morbidity at term and the risk of childhood asthma. Arch Dis Child. 2004;89:956–960
  23. Shohat M, Levy G, Levy I, Schonfeld T, Merlob P. Transient tachypnoea of the newborn and asthma. Arch Dis Child. 1989;64:277–279
  24. Schaubel D, Johansen H, Dutta M, Desmeules M, Becker A, Mao Y. Neonatal characteristics as risk factors for preschool asthma. J Asthma. 1996;33:255–264
  25. Dani C, Reali MF, Bertini G, Wiechmann L, Spagnolo A, Tangucci M, et al. Italian Group of Neonatal Pneumology Risk factors for the development of respiratory distress syndrome and transient tachypnoea in newborn infants. Eur Respir J. 1999;14:155–159
  26. Demissie K, Marcella SW, Breckenridge MB, Rhoads GG. Maternal asthma and transient tachypnea of the newborn. Pediatrics. 1998;102:84–90
  27. Schatz M, Zeiger RS, Hoffman CP, Saunders BS, Harden KM, Forsythe AB. Increased transient tachypnea of the newborn in infants of asthmatic mothers. Am J Dis Child. 1991;145:156–158
  28. Barnes PJ. Endogenous catecholamines and asthma. J Allergy Clin Immunol. 1986;77:791–795
  29. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol. 1997;159:1739–1745
  30. Bjorksten B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol. 2001;108:516–520
  31. Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol. 2001;107:129–134
  32. Romagnani S. The Th1/Th2 paradigm and allergic disorders. Allergy. 1998;53:12–15

 This research was funded by the Operating Grant, New Investigator Award and New Emerging Team Programs of the Canadian Institutes of Health Research; the Canadian Allergy, Asthma and Immunology Foundation; the Manitoba Institute of Child Health; the National Training Program in Allergy and Asthma; and AllerGen (Allergy, Genes and Environment Network).

 Data were accessed from the Population Health Research Data Repository at the Manitoba Centre for Health Policy, Winnipeg, Manitoba, Canada.

 The results and conclusions are those of the authors and no official endorsement by Manitoba Health was intended or should be inferred.

PII: S0022-3476(07)00151-5

doi: 10.1016/j.jpeds.2007.02.021

The Journal of Pediatrics
Volume 151, Issue 1 , Pages 29-33 , July 2007