Transient Tachypnea of the Newborn May Be an Early Clinical Manifestation of Wheezing Symptoms

Liem, Joel J.; Huq, Shamima I.; Ekuma, Okechukwu; Becker, Allan B.; Kozyrskyj, Anita L.

doi:10.1016/j.jpeds.2007.02.021

« Previous Next »The Journal of Pediatrics
Volume 151, Issue 1 , Pages 29-33, July 2007

Transient Tachypnea of the Newborn May Be an Early Clinical Manifestation of Wheezing Symptoms

Joel J. Liem, MD, FRCPC
- From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Shamima I. Huq, BSc
- Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.
Okechukwu Ekuma, MSc
- Manitoba Centre for Health Policy, Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Allan B. Becker, MD, FRCPC
- From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Anita L. Kozyrskyj, PhD
- From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
- Manitoba Centre for Health Policy, Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
- Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.
- Reprint requests: Anita L. Kozyrskyj, PhD, Faculty of Pharmacy, Rm 210 Pharmacy Bldg, University of Manitoba, Winnipeg, Manitoba, Canada R3PT 2N2.

Received 13 March 2006; received in revised form 12 December 2006; accepted 5 February 2007.

Objective

To determine risk factors associated with transient tachypnea of the newborn (TTN) and whether TTN is associated with development of wheezing syndromes in early life.

Study design

The Population Health Research Data Repository at the Manitoba Centre for Health Policy is a healthcare administrative and prescription database. Data for children diagnosed with a wheezing syndrome (defined as bronchiolitis, acute bronchitis, chronic bronchitis, asthma, or prescription for asthma medication) were obtained. Term children diagnosed with TTN at birth were selected. Cox proportional hazards regression analysis for time to first event of hospitalizations, physician visits, or prescription for an asthma medication up to 7 years of age were calculated. The hazard ratios for wheezing in a child with TTN were compared with healthy newborns.

Results

Twelve thousand seven hundred sixty-three children were born at term in 1995 and currently live in the province of Manitoba. Of these children, 308 (2.4%) developed TTN. Maternal asthma, birth weight ≥4500 g, male sex, and urban location were risk factors for development of TTN. Infants with TTN at birth were at significantly increased risk of a wheezing disorder in childhood (adjusted hazard ratio [HR] = 1.17, 95% CI 1.02-1.34).

Conclusion

TTN is associated with development of wheezing syndromes in childhood.

Abbreviations: HR, Hazard ratio, TTN, Transient tachypnea of the newborn, TTN-PI, Transient tachypnea of the newborn excluding other pulmonary insults

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This research was funded by the Operating Grant, New Investigator Award and New Emerging Team Programs of the Canadian Institutes of Health Research; the Canadian Allergy, Asthma and Immunology Foundation; the Manitoba Institute of Child Health; the National Training Program in Allergy and Asthma; and AllerGen (Allergy, Genes and Environment Network).

Data were accessed from the Population Health Research Data Repository at the Manitoba Centre for Health Policy, Winnipeg, Manitoba, Canada.

The results and conclusions are those of the authors and no official endorsement by Manitoba Health was intended or should be inferred.

PII: S0022-3476(07)00151-5

doi:10.1016/j.jpeds.2007.02.021

« Previous Next »The Journal of Pediatrics
Volume 151, Issue 1 , Pages 29-33, July 2007

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