The Journal of Pediatrics
Volume 150, Issue 6 , Pages 587-591 , June 2007

Growth Hormone Treatment and Left Ventricular Dimensions in Turner Syndrome

  • Lea Ann Matura, PhD

      Affiliations

    • Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
    • Corresponding Author InformationReprint requests: Dr. Lea Ann Matura, National Institutes of Health, CRC 1-3330, 10 Center Drive, Bethesda, MD 20892.
    • ,
  • Vandana Sachdev, MD

      Affiliations

    • National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
    • ,
  • Vladimir K. Bakalov, MD

      Affiliations

    • Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
    • ,
  • Douglas R. Rosing, MD

      Affiliations

    • National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
    • ,
  • Carolyn A. Bondy, MD

      Affiliations

    • Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD

Received 18 October 2006 ,Revised 6 December 2006 ,Accepted 1 February 2007.

References 

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  3. Sybert VP. Cardiovascular malformations and complications in Turner syndrome. Pediatrics. 1998;101:e11
  4. Bondy C. New issues in the diagnosis and management of Turner syndrome. Rev Endocr Metab Disord. 2005;6:269–280
  5. Bondy CA, Van PL, Bakalov VK, Sachdev V, Malone CA, Ho VB, et al. Prolongation of the cardiac QTc interval in Turner syndrome. Medicine (Baltimore). 2006;85:75–81
  6. Bondy CA, Ceniceros I, Van PL, Bakalov VK, Rosing DR. Prolonged rate-corrected QT interval and other electrocardiogram abnormalities in girls with Turner syndrome. Pediatrics. 2006;118:e1220–e1225
  7. Gravholt CH, Hansen KW, Erlandsen M, Ebbehoj E, Christiansen JS. Nocturnal hypertension and impaired sympathovagal tone in Turner syndrome. J Hypertens. 2006;24:353–360
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  12. van Pareren YK, de Muinck Keizer-Schrama SM, Stijnen T, Sas TC, Jansen M, Otten BJ, et al. Final height in girls with Turner syndrome after long-term growth hormone treatment in three dosages and low-dose estrogens. J Clin Endocrinol Metab. 2003;88:1119–1125
  13. Colao A, Vitale G, Pivonello R, Ciccarelli A, Di Somma C, Lombardi G. The heart: an end-organ of GH action. Eur J Endocrinol. 2004;151:S93–S101
  14. Maison P, Chanson P. Cardiac effects of growth hormone in adults with growth hormone deficiency: a meta-analysis. Circulation. 2003;108:2648–2652
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  16. Cittadini A, Berggren A, Longobardi S, Ehrnborg C, Napoli R, Rosen T, et al. Supraphysiological doses of GH induce rapid changes in cardiac morphology and function. J Clin Endocrinol Metab. 2002;87:1654–1659
  17. Shulman DI, Root AW, Diamond FB, Bercu BB, Martinez R, Boucek RJ. Effects of one year of recombinant human growth hormone (GH) therapy on cardiac mass and function in children with classical GH deficiency. J Clin Endocrinol Metab. 2003;88:4095–4099
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  19. Radetti G, Crepaz R, Milanesi O, Paganini C, Cesaro A, Rigon F, et al. Cardiac performance in Turner’s syndrome patients on growth hormone therapy. Horm Res. 2001;55:240–244
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  21. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. American Society of Echocardiography Committee on Standards Subcommittee on Quantitation of Two-Dimensional Echocardiograms Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr. 1989;2:358–367
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  23. de Simone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, de Divitiis O, et al. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol. 1992;20:1251–1260
  24. Nathwani NC, Unwin R, Brook CG, Hindmarsh PC. Blood pressure and Turner syndrome. Clin Endocrinol (Oxf). 2000;52:363–370
  25. Bondy CA, Van PL, Bakalov VK, Ho VB. Growth hormone treatment and aortic dimensions in Turner syndrome. J Clin Endocrinol Metab. 2006;91:1785–1788

 Supported by the intramural research program of the National Institute of Child Health and Human Development, National Institutes of Health.The authors have nothing to disclose and have no potential conflict of interest, real or perceived, to report. Lea Ann Matura wrote the first draft of the manuscript. No one involved in the production of the manuscript received any honorarium, grant, or other form of payment.

PII: S0022-3476(07)00127-8

doi: 10.1016/j.jpeds.2007.02.009

The Journal of Pediatrics
Volume 150, Issue 6 , Pages 587-591 , June 2007

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