The Journal of Pediatrics
Volume 150, Issue 5 , Pages 491-497 , May 2007

White Coat Hypertension in Childhood: Evidence for End-Organ Effect

Received 23 June 2006 ,Revised 19 December 2006 ,Accepted 26 January 2007.

References 

  1. Mancia G, Bertinieri G, Grassi G, Parati G, Pomidossi G, Ferrarri A. Effects of blood pressure measurements by the doctor on patient’s blood pressure and heart rate. Lancet. 1983;322:695–698
  2. Pickering T. Recommendations for the use of home(self) and ambulatory blood pressure monitoring. Am J Hypertens. 1995;9:1–11
  3. Pickering TG, Coats A, Mallion JM, Mancia G, Verdecchia P. Blood pressure monitoring (Task Force V: White coat hypertension). Blood Press Monit. 1999;4:333–341
  4. Verdecchia P, Schillaci G, Boldrini F, Zampi I, Porcellati C. Variability between current definitions of “normal” ambulatory blood pressure: implications in the assessment of white coat hypertension. Hypertension. 1992;20:555–562
  5. Khattar RS, Senior R, Lahiri A. Cardiovascular outcome in white-coat versus sustained mild hypertension: a 10-year follow-up study. Circulation. 1998;98:1892–1897
  6. Kario K, Shimada K, Schwartz JE, Matsuo T, Hoshide S, Pickering TG. Silent and clinically overt stroke in older Japanese subjects with white coat and sustained hypertension. Am J Hypertens. 2001;14:855–860
  7. Polonia JJ, Gama GM, Silva JA, Amaral C, Martins LR, Bertoquini SE. Sequential follow-up of clinic and ambulatory blood pressure evaluation in a low risk population of white-coat-hypertensive patients and in normotensives. Blood Press Monit. 2005;10:57–64
  8. Verdecchia P, Schillaci G, Borgioni C, Gattobigio R, Ciucci A, Porcellati C. White coat hypertension. Lancet. 1996;348:1444–1445
  9. Gustaven PH, Hoegholm A, Bang LE, Kristensen KS. White coat hypertension is a cardiovascular risk factor: a 10-year follow-up study. J Hum Hypertens. 2003;17:811–817
  10. Verdecchia P, Reboldi GP, Angeli F, Schillaci G, Schwartz JE, Pickering TG, et al. Short- and long-term incidence of stroke in white-coat hypertension. Hypertension. 2005;45:203–208
  11. Hornsby JL, Mongan PF, Taylor AT, Treiber FA. “White coat” hypertension in children. J Fam Pract. 1991;33:617–623
  12. Sorof JM, Portman RJ. White coat hypertension in children with elevated casual blood pressures. J Pediatr. 2000;137:493–497
  13. Matsuoka S, Kawamura K, Honda M, Awazu M. White coat effect and white coat hypertension in pediatric patients. Pediatr Nephrol. 2002;17:950–953
  14. Sorof JM, Poffenbarger T, Franco K, Portman R. Evaluation of white coat hypertension in children: importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens. 2001;14:855–860
  15. Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N. White-coat and masked hypertension in children: association with target-organ damage. Pediatr Nephrol. 2005;20:1151–1155
  16. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham study. N Engl J Med. 1990;322:1561–1566
  17. Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of left ventricular mass and geometry to morbidity and mortality in men and women with essential hypertension. Ann Intern Med. 1991;114:345–352
  18. Daniels SR, Meyer RA, Liang Y, Bove KE. Echocardiographically determined left ventricular mass index in normal children and young adults. J Am Coll Cardiol. 1988;12:703–708
  19. DeSimone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, De Divitiis O, et al. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol. 1992;20:1251–1260
  20. DeSimone G, Devereux RB, Daniels SR, Koren MJ, Meyer RA, Laragh JH. Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their ability to predict cardiovascular risk. J Am Coll Cardiol. 1995;25:1056–1062
  21. Daniels SR, Loggie J, Khoury P, Kimball TR. Left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998;97:1907–1911
  22. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. Pediatrics. 1996;98:649–658
  23. Soergel M, Kirschstein M, Busch C, Danne T, Gellermann J, Holl R, et al. Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects. J Pediatr. 1997;130:178–184
  24. Bruce RA, Kusumi F, Hosmer D. Maximal oxygen uptake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J. 1973;85:546–559
  25. Ahmad F, Kavey REW, Kveselis DA, Gaum WE, Smith FC. Responses of non-obese white children to treadmill exercise. J Pediatr. 2001;139:284–290
  26. Riopel DA, Taylor AB, Hohn AR. Blood pressure, heart rate, pressure-rate product and electrocardiographic changes in healthy children during treadmill exercise. Am J Cardiol. 1979;44:697–704
  27. Sahn DJ, DeMaria A, Kisslo J, Weyman A Committee on M-Mode Standardization of the American Society of Echocardiography. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072–1083
  28. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–458
  29. Gillman MW, Cook NR. Blood pressure measurement in childhood epidemiologic studies. Circulation. 1995;92:1049–1057
  30. Borow KM, Newburger JW. Noninvasive estimation of central aortic pressure using the oscillometric method for analyzing systemic artery pulsatile flow: comparative study of indirect systolic, diastolic and mean brachial artery pressure with simultaneous direct ascending aortic pressure measurements. Am Heart J. 1982;103:879–886
  31. Park MK, Menard SW, Yuan C. Comparison of auscultatory and oscillometric blood pressures. Arch Pediatr Adol Med. 2001;155:50–53
  32. Coppieters Y, Parent F, Berghmans L, Godin I, Leveque A. Blood pressure measurement in epidemiologic studies in teenagers. Eur J Epidemiol. 2001;17:901–906
  33. Keijzer-Veen MG, Finken MJJ, Nauta J, Dekker FW, Hille ETM, Frolich M, et al. Dutch POPS-19 Collaborative Study Group Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? (A prospective follow-up study in the Netherlands). Pediatrics. 2005;116:725–731
  34. Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ. Overweight, ethnicity and the prevalence of hypertension in school-aged children. Pediatrics. 2004;113:475–482
  35. Flynn JT, Alderman MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol. 2005;20:961–966
  36. Flynn JT. Differentiation between primary and secondary hypertension in children using ambulatory blood pressure monitoring. Pediatrics. 2002;110:89–93
  37. Sorof JM. Systolic hypertension in children: benign or beware?. Pediatr Nephrol. 2001;16:517–525
  38. Verdecchia P, Angeli F, Reboldi G, Gattobigio R, Sardone MG, Porcellati C, et al. Diagnosis of white-coat hypertension based solely on systolic blood pressure: the Piuma study. [abstract] Am J Hypertens. 2005;18:46A
  39. Lurbe E, Sorof JM, Daniels SR. Clinical and research aspects of ambulatory blood pressure monitoring in children. J Pediatr. 2004;144:7–16
  40. Lim PO, MacFadyen RJ, MacDonald TM. White coat hypertension. Lancet. 1996;348:1445–1446
  41. O’Brien E, Sheridan J, O’Malley K. Dippers and non-dippers. Lancet. 1988;2:397
  42. Verdecchia P, Schillaci G, Guerrieri M, Gatteschi C, Benemio G, Boldrini F, et al. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation. 1990;81:528–536
  43. Ohkubo T, Imai Y, Tsuji I, Watanabe N, Minami N, Nagai K. Relation between nocturnal decline in blood pressure and mortality (The Ohasama Study). Am J Hypertens. 1997;10:1201–1207
  44. Vaindirlis I, Peppa-Petrikiou M, Dracopoulou M, Manoli I, Dacou-Voutetakis C. “White coat hypertension” in adolescents: increased values of urinary cortisol and endothelin. J Pediatr. 2000;136:359–364
  45. Smith PA, Graham LN, Mackintosh AF, Stoker JB, Mary DASG. Sympathetic neural mechanisms in white-coat hypertension. J Am Coll Cardiol. 2002;40:126–132
  46. Neumann SA, Jennings JR, Muldoon MF, Manuck SB. White-coat hypertension and autonomic nervous system dysregulation. Am J Hypertens. 2005;18:584–588
  47. Mahoney LT, Schieken RM, Clarke WR, Lauer RM. Left ventricular mass and exercise responses predict future blood pressure. Hypertension. 1988;12:206
  48. Manolio TA, Burke GL, Savage S, Sidney S, Gardin JM, Oberman A. Exercise blood pressure response and 5-year risk of elevated blood pressure in a cohort of young adults: the CARDIA study. Am J Hypertens. 1994;7:234–241
  49. Kamarck TW, Eranen J, Jennings R, Manuck SB, Everson SA, Kaplan GA, et al. Anticipatory blood pressure responses to exercise are associated with left ventricular mass in Finnish men. Circulation. 2000;102:1394–1399
  50. Everson SA, Kaplan GA, Goldberg DE, Salonen JT. Anticipatory blood pressure response to exercise predicts future high blood pressure in middle-aged men. Hypertension. 1996;27:1059–1064
  51. Daniels SD, Meyer RA, Loggie JMH. Determinants of cardiac involvement in children and adolescents with essential hypertension. Circulation. 1990;82:1243–1248
  52. Chinali M, de Simone G, Roman MJ, Lee ET, Best LG, Howard BV, et al. Impact of obesity on cardiac geometry in a population of adolescents: the Strong Heart Study. J Am Coll Cardiol. 2006;47:2267–2273
  53. Treiber FA, McCaffrey , Pflieger K, Raunikar RA, Strong WB, Davis H. Determinants of left ventricular mass in normal children. Am J Hypertens. 1993;6:505–513
  54. Urbina EM, Gidding SS, Bao W, Pickoff AS, Berdussis K, Berenson GS. Effect of body size, ponderosity and blood pressure on left ventricular growth in children and young adults in the Bogalusa Heart Study. Circulation. 1995;91:2400–2406
  55. Hanevold C, Waller J, Daniels S, Portman R, Sorof J. The effects of obesity, gender and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the international pediatric hypertension association. Pediatrics. 2004;113:328–333

 None of the authors has any conflicts of interest to disclose.

PII: S0022-3476(07)00108-4

doi: 10.1016/j.jpeds.2007.01.033

The Journal of Pediatrics
Volume 150, Issue 5 , Pages 491-497 , May 2007