The Journal of Pediatrics
Volume 150, Issue 3 , Pages 216-219 , March 2007

Patent Ductus Arteriosus: Evidence for and against Treatment

  • Ronald I. Clyman, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Dr Ronald I. Clyman, Box 0544, HSW 1408, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143-0544.
    • ,
  • Nancy Chorne, MD

References 

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  2. Campbell M. Natural history of persistent ductus arteriosus. Br Heart J. 1968;30:4–13
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  4. Van Israel N, Dukes-McEwan J, French AT. Long-term follow-up of dogs with patent ductus arteriosus. J Small Anim Pract. 2003;44:480–490
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  13. Mahony L, Carnero V, Brett C, Heymann MA, Clyman RI. Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants. N Engl J Med. 1982;306:506–510
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  18. Cassady G, Crouse DT, Kirklin JW, Strange MJ, Jonier CH, Godoy G, et al. A randomized, controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth. N Engl J Med. 1989;320:1511–1516
  19. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006;89:330–335
  20. Coalson JJ, Winter VT, Siler-Khodr T, Yoder BA. Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med. 1999;160:1333–1346
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  22. Watterberg KL, Gerdes JS, Cole CH, Aucott SW, Thilo EH, Mammel MC, et al. Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial. Pediatrics. 2004;114:1649–1657
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  25. Leffler CW, Busija DW, Fletcher AM, Beasley DG, Hessler JR, Green RS. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Pediatr Res. 1985;19:1160–1164
  26. Vohr BR, Allan WC, Westerveld M, Schneider KC, Katz KH, Makuch RW, et al. School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial. Pediatrics. 2003;111:e340–e346
  27. Ment LR, Vohr B, Allan W, Westerveld M, Sparrow SS, Schneider KC, et al. Outcome of children in the indomethacin intraventricular hemorrhage prevention trial. Pediatrics. 2000;105:485–491
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  29. Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts RS, Saigal S, et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth- weight infants. N Engl J Med. 2001;344:1966–1972
  30. Moin F, Kennedy KA, Moya FR. Risk factors predicting vasopressor use after patent ductus arteriosus ligation. Am J Perinatol. 2003;20:313–320
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  33. Chorne N, Leonard C, Piecuch R, Clyman R. Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity. Pediatrics. 2007;(in press)
  34. Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS. Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr. 1983;102:895–906
  35. McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, et al. Effect of ductus ligation on cardiopulmonary function in premature baboons. Am J Respir Crit Care Med. 2005;172:1569–1574
  36. Chang LY, McCurnin D, Yoder B, Clyman R. PDA ligation and alveolar growth. PAS 2007 database 2007;61 in press.

 Supported by grants from U.S. Public Health Service (NIH grants HL46691, HL56061) and by a gift from the J and B Gates Foundation.

PII: S0022-3476(07)00010-8

doi: 10.1016/j.jpeds.2006.12.048

The Journal of Pediatrics
Volume 150, Issue 3 , Pages 216-219 , March 2007

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