The Journal of Pediatrics
Volume 150, Issue 2 , Pages 121-122 , February 2007

Is There a Role for β-Adrenergic Blockers in Treating Hypertension in Children?

  • Russell W. Chesney, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Russell W. Chesney, MD, Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap, Room 304, Memphis, TN 38103.
    • ,
  • Deborah P. Jones, MD

References 

  1. Christensen ML, Helms RA, Chesney RW. Is pediatric labeling really necessary?. Pediatrics. 1999;104:593–597
  2. Chesney RW, Christensen ML. Changing requirements for evaluation of pharmacologic agents. Pediatrics. 2004;113:1128–1132
  3. Chesney RW, Adamson P, Wells T, Wilson JT, Walson PD. The testing of antihypertensive medications in children: report of the Antihypertensive Agent Guidelines Subcommittee of the Pediatric Pharmacology Research Units. Pediatrics. 2001;107:558–561
  4. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. Fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114:555–576
  5. Batisky DL, Sorof JM, Sugg J, Llewellyn M, Klibaner M, Hainer JW, et al. Efficacy and safety of extended-release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience. J Pediatr. 2007;150:134–139
  6. Sorof JM, Cargo P, Graepel J, Humphrey D, King E, Rolf C, et al. β-blocker/thiazide combination for treatment of hypertensive children: a randomized double-blind, placebo-controlled trial. Pediatr Nephrol. 2002;17:345–350
  7. Sorof JM, Urbina EM, Cunningham RJ, Hogg RJ, Moxey-Mims M, Eissa MA, et al. Screening for eligibility in the study of antihypertensive medication in children: experience from the Ziac Pediatric Hypertension Study. Am J Hypertens. 2001;14:783–787
  8. Flynn JT. Ethics of placebo use in pediatric clinical trials: the case of antihypertensive drug studies. Hypertension. 2003;42:865–869
  9. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonised Tripartite Guideline E10: Choice of control group and related issues in clinical trials. 2000;July. Available at http://www.ich.org/pdfICH/e10step4.pdf. Accessed September 2006
  10. Woroniecki RP, Flynn JT. How are hypertensive children evaluated and managed? (A survey of North American pediatric nephrologists). Pediatr Nephrol. 2005;20:791–797

PII: S0022-3476(06)01173-5

doi: 10.1016/j.jpeds.2006.11.064

The Journal of Pediatrics
Volume 150, Issue 2 , Pages 121-122 , February 2007

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