The Journal of Pediatrics
Volume 150, Issue 2 , Pages 122-124 , February 2007

PET Scanning for Infants with HHI: A Small Step for Affected Infants, A Giant Leap for the Field

  • Mark A. Sperling, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Mark A. Sperling, MD, Children’s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA.

References 

  1. McQuarrie I. Idiopathic spontaneously occurring hypoglycemia in infants: clinical significance of problem and treatment. AMA Am J Dis Child. 1954;87:399–428
  2. Cochrane WA, Payne WW, Simpkiss MJ, Woolf LI. Familial hypoglycemia precipitated by amino acids. J Clin Invest. 1956;35:411–422
  3. Menon RK, Sperling MA. Carbohydrate metabolism. Semin Perinatol. 1988;12:157–162
  4. Sperling MA, Menon RK. Differential diagnosis and management of neonatal hypoglycemia. Pediatr Clin North Am. 2004;51:703–723
  5. Ashcroft FA. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest. 2005;115:2047–2058
  6. Hussain K, Cosgrove KE. From congenital hyperinsulinism to diabetes mellitus: the role of pancreatic beta-cell KATP channels. Pediatr Diabetes. 2005;6:103–113
  7. deLonlay-Debeney P, Poggi-Travert F, Fournet JC, Sempoux C, Vici CD, Brunelle F, et al. Clinical features of 52 neonates with hyperinsulinism. N Engl J Med. 1999;15:1169–1175
  8. de Lonlay P, Fournet JC, Rahier J, Gross-Morand MS, Poggi-Travert F, Foussier V, et al. Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. J Clin Invest. 1997;100:802–807
  9. Verkarre V, Fournet JC, de Lonlay P, Gross-Morand MS, Devillers M, Rahier J, et al. Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia. J Clin Invest. 1998;102:1286–1291
  10. Giurgea I, Laborde K, Touati G, Bellanne-Chantelot C, Nassogne MC, Sempoux C, et al. Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism. J Clin Endocrinol Metab. 2004;89:925–929
  11. Stanley CA, Thornton PS, Ganguly A, MacMullen C, Underwood P, Bhatia P, et al. Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation. J Clin Endocrinol Metab. 2004;89:288–296
  12. de Lonlay P, Simon-Carre A, Ribeiro MJ, Boddaert N, Giurgea I, Laborde K, et al. Congenital hyperinsulinism: pancreatic [18F] Fluoro-L-DOPA positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion. J Clin Endocrinol Metab. 2006;91:933–940
  13. Otonkoski T, Nanto-Salonen K, Seppanen M, Veijola R, Huopio H, Hussain K, et al. Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography. Diabetes. 2006;55:13–18
  14. Hussain K, Seppanen M, Nanto-Salonen K, Adzick NS, Stanley CA, Thornton P, et al. The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography. J Clin Endocrinol Metab. 2006;91:2839–2842
  15. Hardy OT, Hernandez-Pampaloni M, Saffer JR, Suchi M, Ruchelli E, Zhuang H, et al. Diagnosis and localization of focal congential hyperinsulinism by 18F-fluorodopa PET scan. J Pediatr. 2007;150:140–145
  16. Dekelbab B, Sperling MA. Recent advances in hyperinsulinemic hypoglycemia of infancy. Acta Paediatr. 2006;95:1157–1164

PII: S0022-3476(06)01127-9

doi: 10.1016/j.jpeds.2006.11.058

The Journal of Pediatrics
Volume 150, Issue 2 , Pages 122-124 , February 2007

Article Tools