Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms

Outcome of death or neurosensory impairment and age since birth at time of PDA ligation.

Relationship between the rate of PDA ligation in study infants in individual centers and the outcomes of death (A), death or impairment (B), and neurosensory impairment (C). The circles represent the data of individual centers. The area of each circle is proportional to the number of patients enrolled in each center. The fitted weighted regression line is shown along with its P value. After adjustment for antenatal steroid use, gestational age at birth, sex, multiple births, and mother’s education, the P values for death, death or impairment, and neurosensory impairment were .47, .30, and .21, respectively.