Table of contents

Article Outline

• Notes from the Association of Medical School Pediatric Department Chairs, Inc
• Editorials
• Special article
• Original articles
• Grand rounds
• Clinical and laboratory observations
• Current best evidence
• Insights
• Letters
• Reader services

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Notes from the Association of Medical School Pediatric Department Chairs, Inc 

A UNIFORM THIRD-YEAR APPLICATION AND OFFER DATE FOR PEDIATRIC FELLOW APPLICANTS: PRO AND CON 587

F. Bruder Stapleton, MD and Samuel E. Lux, MD, Seattle, Washington, and Boston, Massachusetts

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Editorials 

RECOMMENDATION FOR AN ADOLESCENT DOSE OF TETANUS AND DIPHTHERIA TOXOIDS AND ACELLULAR PERTUSSIS VACCINE: REASSURANCE FOR THE FUTURE 589

Scott A. Halperin, MD, Halifax, Nova Scotia, Canada

MATERNAL MILK IGA AND MOTHER-TO-CHILD TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS: NOT A SILVER SPOON 591

Rupert Kaul, MD, PhD, Toronto, Ontario, Canada

VARIATION AND “ABNORMALITY”: RECOGNIZING THE DIFFERENCES 593

Peter Rosenbaum, MD, FRCP(C), Hamilton, Ontario, Canada

ASYMMETRIC HEADS AND FAILURE TO CLIMB STAIRS 594

James S. Kemp, MD, St Louis, Missouri

QUESTIONS IN THE MANAGEMENT OF SICKLE CELL 595

Rupa Redding-Lallinger, MD, Chapel Hill, North Carolina

EMERGENCY DEPARTMENT ADMISSION DECISION-MAKING: AN OPPORTUNITY FOR QUALITY IMPROVEMENT IN MEDICAL EDUCATION AND PRACTICE 598

Paul V. Miles, MD, Chapel Hill, North Carolina

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Special article 

PEDIATRIC WORKFORCE: A LOOK AT PEDIATRIC EMERGENCY MEDICINE DATA FROM THE AMERICAN BOARD OF PEDIATRICS 600

Linda A. Althouse, PhD, and James A. Stockman, III, MD, Chapel Hill, North Carolina

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Original articles 

SAFETY OF REDUCED-ANTIGEN-CONTENT TETANUS–DIPHTHERIA–ACELLULAR PERTUSSIS VACCINE IN ADOLESCENTS AS A SIXTH CONSECUTIVE DOSE OF ACELLULAR PERTUSSIS–CONTAINING VACCINE 603

Fred Zepp, MD, Markus Knuf, MD, Pirmin Habermehl, MD, Wilma Mannhardt-Laakmann, MD, Barbara Howe, MD, and Leonard R. Friedland, MD, Mainz, Germany, and King of Prussia, Pennsylvania

HIV-SPECIFIC SECRETORY IGA IN BREAST MILK OF HIV-POSITIVE MOTHERS IS NOT ASSOCIATED WITH PROTECTION AGAINST HIV TRANSMISSION AMONG BREAST-FED INFANTS 611

Louise Kuhn, PhD, Daria Trabattoni, BS, Chipepo Kankasa, MD, Moses Sinkala, MD, Francesca Lissoni, BS, Mrinal Ghosh, PhD, Grace Aldrovandi, MD, Don Thea, MD, and Mario Clerici, MD, New York, New York, Milano, Italy, Lusaka, Zambia, Los Angeles, California, and Boston, Massachusetts

EARLY GROSS MOTOR DEVELOPMENT OF PRETERM INFANTS ACCORDING TO THE ALBERTA INFANT MOTOR SCALE 617

I.C. van Haastert, MA, PT, PCS, L.S. de Vries, MD, PhD, P.J.M. Helders, MSc, PhD, PT, PCS, and M.J. Jongmans, MSc, PhD, Utrecht, The Netherlands

ASSOCIATION BETWEEN SLEEP POSITION AND EARLY MOTOR DEVELOPMENT 623

Annette Majnemer PhD, OT(C), and Ronald G. Barr, MDCM, FRCPC, Montreal, Quebec, Canada, and Vancouver, British Columbia

50 YEARS AGO IN THE JOURNAL OF PEDIATRICS—MECONIUM STAINING OF NEWBORN INFANTS 629

Nestor E. Vain, MD, Buenos Aires, Argentina

SUDDEN INFANT DEATH SYNDROME: RISK FACTORS FOR INFANTS FOUND FACE DOWN DIFFER FROM OTHER SIDS CASES 630

John M.D. Thompson, PhD, Bradley T. Thach, MD, David M.O. Becroft, MD, Edwin A. Mitchell, DSc, on behalf of the New Zealand Cot Death Study Group, Auckland, New Zealand, and St. Louis, Missouria

SURFACTANT PHOSPHATIDYLCHOLINE METABOLISM IN NEONATES WITH MECONIUM ASPIRATION SYNDROME 634

Daphne J. Janssen, MD, PhD, Virgilio P. Carnielli, MD, PhD, Paola Cogo, MD, Kajsa Bohlin, MD, Aaron Hamvas, MD, PhD, Ingrid H. Luijendijk, Jan Erik H. Bunt, MD, PhD, Dick Tibboel, MD, and Luc J. Zimmermann, MD, PhD, Rotterdam, The Netherlands, Ancona and Padova, Italy, Stockholm, Sweden, St. Louis, Missouri, and Maastricht, The Netherlands

IMMATURE SUCKING PATTERNS IN INFANTS OF MOTHERS WITH DIABETES 640

Ruben Bromiker, MD, Adi Rachamim, MD, Cathy Hammerman, MD, Michael Schimmel, MD, Michael Kaplan, MB, ChB, and Barbara Medoff-Cooper, PhD, Jerusalem and Be’er Sheva, Israel, and Philadelphia, Pennsylvania

ASSOCIATION OF EMERGENCY DEPARTMENT CARE FACTORS WITH ADMISSION AND DISCHARGE DECISIONS FOR PEDIATRIC PATIENTS 644

James M. Chamberlain, MD, Kantilal M. Patel, PhD, and Murray M. Pollack, MD, MBA, Washington, DC

GENETIC AND PHYSIOLOGIC CORRELATES OF LONGITUDINAL IMMUNOREACTIVE TRYPSINOGEN DECLINE IN INFANTS WITH CYSTIC FIBROSIS IDENTIFIED THROUGH NEWBORN SCREENING 650

Marci K. Sontag, PhD, Mary Corey, PhD, John E. Hokanson, PhD, Julie A. Marshall, PhD, Steve S. Sommer, MD, PhD, Gary O. Zerbe, PhD, Frank J. Accurso, MD, Denver, Colorado, Toronto, Ontario, Canada, and Duarte, California

STUDY OF A NOVEL PANCREATIC ENZYME REPLACEMENT THERAPY IN PANCREATIC INSUFFICIENT SUBJECTS WITH CYSTIC FIBROSIS 658

Drucy Borowitz, MD, Christopher H. Goss, MD, MSc, Stacey Limauro, MS, Michael W. Konstan, MD, Kathryn Blake, PharmD, Susan Casey, RD, Alexandra L. Quittner, PhD, and Frederick T. Murray, MD, Buffalo, New York, Seattle, Washington, Cambridge, Massachusetts, Cleveland, Ohio, Jacksonville and Miami, Florida

EFFICACY AND SAFETY OF FLUTICASONE PROPIONATE HYDROFLUOROALKANE INHALATION AEROSOL IN PRE–SCHOOL-AGE CHILDREN WITH ASTHMA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY 663

Paul Y. Qaqundah, MD, Robert W. Sugerman, MD, Elaina Ceruti, MD, Jorge Fernando Maspero, MD, Joseph F. Kleha, BS, Catherine A. Scott, BA, Wei Wu, PhD, Rashmi Mehta, PhD, and Courtney Crim, MD, Huntington Beach, California, Dallas, Texas, Santiago, Chile, Buenos Aires, Argentina, and Triangle Park, North Carolina

50 YEARS AGO IN THE JOURNAL OF PEDIATRICS—THE PREPARATION AND CLINICAL ADMINISTRATION OF LYOPHILIZED PLATELET MATERIAL TO CHILDREN WITH ACUTE LEUKEMIA AND APLASTIC ANEMIA 670

Kathryn Wheeler, MD, and William B. Slayton, MD, Gainesville, Florida

PROGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN CHILDREN WITH EARLY CHRONIC KIDNEY DISEASE: 2-YEAR FOLLOW-UP STUDY 671

Mark M. Mitsnefes, MD, MS, Thomas R. Kimball, MD, Janis Kartal, RN, Sandra A. Witt, RDCS, Betty J. Glascock, RDCS, Philip R. Khoury, MS, and Stephen R. Daniels, MD, PhD, Cincinnati, Ohio

CAPILLARY REFILL TIME AS AN INDEPENDENT PROGNOSTIC INDICATOR IN SEVERE AND COMPLICATED MALARIA 676

Jennifer A. Evans, MD, MRCP, Juergen May, MD, Daniel Ansong, MB, ChB, Sampson Antwi, MB, ChB, Emmanuel Asafo-Adjei, MB, ChB, Samuel Blay Nguah, MB, ChB, Kingsley Osei-Kwakye, MB, ChB, Alex Osei Yaw Akoto, MB, ChB, Alex Owusu Ofori, MB, ChB, David Sambian, Justice Sylverken, MB, ChB, Wibke Busch, Christian Timmann, MD, Tsiri Agbenyega, MB, ChB, PhD, and Rolf D. Horstmann, MD, Kumasi, Ghana, and Hamburg, Germany

ASSESSING ADRENAL FUNCTION IN PRIMARY CARE SETTINGS WITH A SINGLE SAMPLE SUBCUTANEOUS GLUCAGON TEST 682

Michael S. Kappy, MD, PhD, Amanda Drake, CHA, Dexiang Gao, PhD, and Rebecca Ratliff, RN, Denver, Coloradoa

50 YEARS AGO IN THE JOURNAL OF PEDIATRICS—BRONCHIAL ADENOMA OCCURRING IN CHILDHOOD: A REPORT OF THREE CASES 686

Gary M. Albers, MD, Saint Louis, Missouri

BILATERAL ANORCHIA IN INFANCY: OCCURENCE OF MICROPENIS AND THE EFFECT OF TESTOSTERONE TREATMENT 687

D. Zenaty, MD, F. Dijoud, MD, Y. Morel, MD, S. Cabrol, MD, P. Mouriquand, MD, M. Nicolino, MD, C. Bouvatier, MD, G. Pinto, MD, C. Lecointre, MD, C. Pienkowski, MD, S. Soskin, MD, M. Bost, MD, A. M. Bertrand, MD, A. El-Ghoneimi, MD, C. Nihoul-Fekete, MD, and J. Léger, MD, Paris and Lyon, France

OXIDATIVE STRESS IN CHILDREN RECEIVING VALPROIC ACID 692

Aspasia Michoulas, MD, Vincent Tong, PhD, Xiao Wei Teng, PhD, Thomas K. H. Chang, PhD, Frank S. Abbott, PhD and Kevin Farrell, MB, ChB, Vancouver, British Columbia, Canada

HEARING LOSS IN TURNER SYNDROME 697

Noriko Morimoto, MD, PhD, Toshiaki Tanaka, MD, PhD, Hidenobu Taiji, MD, PhD, Reiko Horikawa, MD, PhD, Yasuhiro Naiki, MD, PhD, Yuji Morimoto, MD, PhD, and Nobuko Kawashiro, MD, PhD, Tokyo and Saitama, Japan

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Grand rounds 

PERSISTENT TACHYPNEA AND HYPOXIA IN A 3-MONTH-OLD TERM INFANT 702

Adrienne Prestridge, MD, Jamie Wooldridge, MD, Gail Deutsch, MD, Lisa R. Young, MD, Susan E. Wert, PhD, Jeffrey A. Whitsett, MD, and Lawrence Nogee, MD, Chicago, Illinois, Cincinnati, Ohio, and Baltimore, Maryland

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Clinical and laboratory observations 

DAYTIME PULSE OXIMETER MEASUREMENTS DO NOT PREDICT INCIDENCE OF PAIN AND ACUTE CHEST SYNDROME EPISODES IN SICKLE CELL ANEMIA 707

Elizabeth C. Uong, MD, Jessica Henderson Boyd, MD, MA, and Michael R. DeBaun, MD, MPH, St. Louis, Missouri

EXCHANGE BLOOD TRANSFUSION COMPARED WITH SIMPLE TRANSFUSION FOR FIRST OVERT STROKE IS ASSOCIATED WITH A LOWER RISK OF SUBSEQUENT STROKE: A RETROSPECTIVE COHORT STUDY OF 137 CHILDREN WITH SICKLE CELL ANEMIA 710

Monica L. Hulbert, MD, Douglas J. Scothorn, MD, PhD, Julie A. Panepinto, MD, MSPH, J. Paul Scott, MD, George R. Buchanan, MD, Sharada Sarnaik, MD, Robert Fallon, MD, PhD, Jen-Yih Chu, MD, Winfred Wang, MD, James F. Casella, MD, Linda Resar, MD, Brian Berman, MD, Thomas Adamkiewicz, MD, Lewis L. Hsu, MD, PhD, Kimberly Smith-Whitley, MD, Donald Mahoney, MD, Gerald Woods, MD, Masayo Watanabe, MD, and Michael R. DeBaun, MD, MPH, St. Louis, Missouri, Dallas and Houston, Texas, Milwaukee, Wisconsin, Detroit, Michigan, Memphis, Tennessee, Baltimore, Maryland, Cleveland, Ohio, Atlanta, Georgia, Philadelphia, Pennsylvania, and Kansas City, Missouri

TRANSALDOLASE DEFICIENCY: A NEW CAUSE OF HYDROPS FETALIS AND NEONATAL MULTI-ORGAN DISEASE 713

Vassili Valayannopoulos, MD, Nanda M. Verhoeven, PhD, Karine Mention, MD, Gajja S. Salomons, PhD, Danièle Sommelet, MD, PhD, Marie Gonzales, MD, Guy Touati, MD, Pascale de Lonlay, MD, PhD, Cornelis Jakobs, PhD, and Jean-Marie Saudubray, MD, PhD, Paris and Vandoeuvre les Nancy, France, and Amsterdam, The Netherlands

SUDDEN CARDIAC DEATH IN YOUNG CHILDREN WITH NEUROFIBROMATOSIS TYPE 1 718

Ronald J. Kanter, MD, Matthew Graham, MD, David Fairbrother, MD, and S. Victor Smith, MD, Durham, Chapel Hill, and Greenville, North Carolina

COMPARISON OF TOTAL WHITE BLOOD CELL COUNT AND SERUM C-REACTIVE PROTEIN LEVELS IN CONFIRMED BACTERIAL AND VIRAL INFECTIONS 721

Ville Peltola, MD, Jussi Mertsola, MD, and Olli Ruuskanen, MD, Turku, Finland

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Current best evidence 

CLINICAL RESEARCH ABSTRACTS FOR PEDIATRICIANS 725

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Insights 

PARALYZED RIGHT HEMIDIAPHRAGM IN A NEWBORN INFANT 730

Colm P.F. O’Donnell, MB, MRCPI, MRCPCH, and Colin J. Morley, MD, FRACP, FRCPCH, Victoria, Australia

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Letters 

A GNRH ANALOG TEST IN DIAGNOSING GONADOTROPIN DEFICIENCY IN MALES WITH DELAYED PUBERTY 731

Roberto Lanes, MD, Caracas, Venezuelaa

REPLY 731

Dyanne Wilson, MBChB, DCH, Paul Hofman, MBChB, and Wayne Cutfield, MD, MBChB, Auckland, New Zealand

EARLY FLUID INTAKE AND CHRONIC LUNG DISEASE 732

Thomas E. Young, MD, Diane D. Marshall, MD, Carl L. Bose, MD, and T. Michael O’Shea, MD, Chapel Hill and Winston-Salem, North Carolina

REPLY 732

William Oh, MD, Brenda B. Poindexter, MD, Rebecca Perrit, MS, James A. Lemons, MD, Charles R. Bauer, MD, Richard A. Ehrenkranz, MD, Barbara J. Stoll, MD, Kenneth Poole, PhD, and Linda L. Wright, MD, Bethesda, Marylanda

THE TEMPO OF PUBERTY 732

Anastasios Papadimitriou, MD, Andreas Fretzayas, MD, and Polyxeni Nicolaidou, MD, Athens, Greece

REPLY 733

Frank M. Biro, MD, Cincinnati, Ohioa

DELAYED ANAPHYLAXIS TO WALNUT FOLLOWING EPINEPHRINE ADMINISTRATION 733

Todd D. Green, MD, Kricia P. Palmer, MD, and A. Wesley Burks, MD, Durham, North Carolinaa

MOTOR FUNCTION IMPROVEMENT AFTER INTRAVENOUS PAMIDRONATE IN OSTEOPOROSIS PSEUDOGLIOMA SYNDROME 734

Natascia Di Iorgi, MD, and Mohamad Maghnie, MD, PhD, Genova, Italy

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Reader services 

GUIDE FOR AUTHORS 10A

INFORMATION FOR READERS 15A

ANNOUNCEMENTS 16A