The Journal of Pediatrics
Volume 149, Issue 6 , Pages 737-738 , December 2006

Influenza vaccine for young children: Two doses are better than one

  • Kathleen Maletic Neuzil, MD, MPH

      Affiliations

    • PATH Immunization Solutions
    • Corresponding Author InformationReprint requests: Dr. Kathleen Maletic Neuzil, PATH Immunization Solutions, 1455 NW Leary Way, Seattle, WA 98107.
    • ,
  • Janet A. Englund, MD

      Affiliations

    • Children’s Hospital and Regional Medical Center Seattle, WA

References 

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  2. Centers for Disease Control. Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease. MMWR Morb Mortal Weekly Rep. 2005;54:893–897
  3. Poehling KA, Edwards KM, Weinberg GA, Szilagyi P, Staat MA, Iwane MK, et al. The underrecognized burden of influenza in young children. N Engl J Med. 2006;355:31–40
  4. Advisory Committee on Immunization Practices (ACIP). Prevention and control of influenza. MMWR Morb Mortal Weekly Rep. 2006;55(RR10):1–42
  5. Neuzil KM, Dupont WD, Wright PF, Edwards KM. Efficacy of inactivated and cold-adapted vaccines against influenza A infection, 1985 to 1990: the pediatric experience. Pediatr Infect Dis J. 2001;20:733–740
  6. Clements DA, Langdon L, Bland C, Walter E. Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care. Arch Pediatr Adolesc Med. 1995;149:1113–1117
  7. Heikkinen T, Ruuskanen O, Waris M, Ziegler T, Arola M, Halonen P. Influenza vaccination in the prevention of acute otitis media in children. Am J Dis Child. 1991;145:445–448
  8. Hoberman A, Greenberg DP, Paradise JI, Rockette HE, Lave JR, Kearney DH, et al. Efficacy of inactivated influenza vaccine in preventing acute otitis media in young children. JAMA. 2003;290:1608–1616
  9. Govaert TM, Thijs CT, Masurel N, Sprenger MJ, Dinant GJ, Knottnerus JA. The efficacy of influenza vaccination in elderly individuals: a randomized double-blind placebo-controlled trial. JAMA. 1994;272:1661–1665
  10. Ritzwoller DP, Bridges CB, Shetterly S, Yamasaki K, Kolczak M, France EK. Effectiveness of the 2003-2004 influenza vaccine among children 6 months to 8 years of age, with 1 vs 2 doses. Pediatrics. 2005;116:153–159
  11. Allison MA, Daley MF, Crane LA, et al. Influenza vaccine effectiveness in healthy 6- to 21-month-old children during the 2003-2004 season. J Pediatr. 2006;149:755
  12. Wright PF, Thompson J, Vaughn WK, Folland DS, Sell SH, Karzon DT. Trials of A/New Jersey/76 virus vaccine in normal children: an overview of age-related antigenicity and reactogenicity. J Infect Dis. 1977;136(suppl):S731–S741
  13. Englund JA, Walter E, Fairchok M, Monto A, Neuzil KM. A comparison of two influenza vaccine schedules in 6- to 23-month-old children. Pediatrics. 2005;115:1039–1047
  14. Englund JA, Walter EB, Gbadebo A, Monto AS, Zhu W, Neuzil KM. Immunization with trivalent inactivated influenza vaccine in partially immunized toddlers. Pediatrics. 2006;3:e579–e585
  15. Walter EB, Neuzil KM, Zhu Y, Fairchok MP, Gagliano ME, Monto AS, et al. Influenza vaccine immunogenicity in 6- to −23-month-old children: are identical antigens necessary for priming?. Pediatrics. 2006;3:e570–e578
  16. Belshe RB, Mendelman PM, Treanor J, King J, Gruber WC, Piedra P, et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine in children. N Engl J Med. 1998;338:1405–1412

PII: S0022-3476(06)00880-8

doi: 10.1016/j.jpeds.2006.09.002

The Journal of Pediatrics
Volume 149, Issue 6 , Pages 737-738 , December 2006

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