The Journal of Pediatrics
Volume 149, Issue 6 , Pages 781-787 , December 2006

Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period

Received 5 December 2005 ,Revised 25 May 2006 ,Accepted 19 August 2006.

References 

  1. Kirby D. Emerging answers: research findings on programs to reduce teen pregnancy (summary). Washington, DC: National Campaign to Prevent Teen Pregnancy; 2001;
  2. Klein JD Committee on Adolescence. Adolescent pregnancy: current trends and issues. Pediatrics. 2005;116:281–286
  3. Fraser AM, Brockert JE, Ward RH. Association of young maternal age with adverse reproductive outcomes. N Engl J Med. 1995;332:1113–1117
  4. http//datasus.gov.br. Accessed November 23, 2005.
  5. US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration. Women and substance use, National Survey on Drug Use and Health results, 2002. Available at http://oas.samhsa.gov/NHSDA/2k2NSDUH/Sect7peTabs54to61.pdf. Accessed November 20, 2005.
  6. Ebrahim SH, Gfroerer J. Pregnancy-related substance use in the United States during 1996-1998. Obstet Gynecol. 2003;101:374–379
  7. Magalhães M, Beani J, Silva L. Maternal drug abuse: effects on the fetus and neonate. In: In proceedings of the Fourth World Congress of Perinatal Medicine, Buenos Aires, Argentina. 1999;p. 821–824
  8. Funkhouser AW, Butz AM, Feng TI, McCaul ME, Rosenstein BJ. Prenatal care and drug use in pregnant women. Drug Alcohol Depend. 1993;33:1–9
  9. Hawthorne JL, Maier RC. Drug abuse in an obstetric population of a mid-sized city. South Med J. 1993;86:1334–1338
  10. World Health Organization. Problemas de salud de la adolescencia: informe de um comitê de expertos de la OMS. Informe Técnico 308. Ginebra: OMS; 1977;
  11. Ballard JL, Khoury JC, Weidig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score expanded to include extremely premature infants. J Pediatr. 1991;119:417–423
  12. World Health Organization. Composite International Diagnostic Interview (CIDI 2.1). Geneva, Switzerland: World Health Organization; 1997;
  13. Lester BM, Tronick EZ. The Neonatal Intensive Care Unit Network Neurobehavioral Scale. Pediatrics. 2004;113:631–699
  14. Society of Hair Testing. Consensus on hair analysis. Available at http//soht.org. Accessed March 10, 2006.
  15. Ostrea EM, Brady MJ, Parks PM, Asensio DC, Naluz A. Drug screening of meconium in infants of drug-dependent mothers: an alternative to urine testing. J Pediatr. 1989;15:474–477
  16. Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol. 1996;87:163–168
  17. Gama SGN, Szwarcwald CL, Leal MC. Pregnancy in adolescence, associated factors and perinatal results among low-income post-partum women. Cad Saude Publica. 2002;18:153–161
  18. Sabroza AR, Leal MC, Gama SGN, Costa JV. A socioeconomic and psychosocial profile of post-partum adolescents in the City of Rio de Janeiro, Brazil, 1999–2001. Cad Saude Publica. 2004;20:S112–S120
  19. Simões VM, da Silva AA, Bettiol H, Lamy-Filho F, Tonial SR, Mochel EG. Characteristics of adolescent pregnancy in São Luis, Maranhão, Brazil. Rev Saude Publica. 2003;37:559–565
  20. Aquino EML, Heilborn ML, Knauth D, Bozon M, Almeida MC, Araújo J, et al. Adolescence and reproduction in Brazil: the heterogeneity of social profiles. Cad Saúde Publica. 2003;19:S377–S388
  21. Thorspecken J, Skopp G, Potsch L. In vitro contamination of hair by marijuana smoke. Clin Chem. 2004;50:596–602
  22. Chiarotti M, Costamagna L. Analysis of 11-nor-9-caboxy-delta(9)-tetrahydrocannabinol in biological samples by GC/MS-MS. Forensic Sci Int. 2000;114:1–6
  23. Ostrea EM, Knapp DK, Tannenbaum L, Ostrea AR, Romero A, Salari V, et al. Estimates of illicit drug use during pregnancy by maternal interview, hair analysis, and meconium analysis. J Pediatr. 2001;138:344–348
  24. Kozer E, Koren G. Effects of prenatal exposure to marijuana. Can Fam Physician. 2001;47:263–264
  25. Day NL, Cornelius M, Goldschmidt L, Richardson G, Robles N, Taylor P. The effects of prenatal tobacco and marijuana use on offspring growth from birth though 3 years of age. Neurotoxicol Teratol. 1992;14:407–414
  26. Hurd YL, Wang X, Anderson V, Beck O, Minkoff H, Dow-Edwards D. Marijuana impairs growth in mid-gestation fetuses. Neurotoxicol Teratol. 2005;27:221–229
  27. English DR, Hulse GK, Milne E, Holman CD, Bower CI. Maternal cannabis use and birth weight: a meta-analysis. Addiction. 1997;92:1553–1560
  28. Gibson GT, Baghurst PA, Colley DP. Maternal alcohol, tobacco and cannabis consumption and the outcome of pregnancy. Aust NZ J Obstet Gynaecol. 1983;23:15–19
  29. Tanda G, Pontieri FE, Di Chiara G. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science. 1997;276:2048–2050
  30. Lester BM, Tronick EZ, LaGasse LL, Seifer R, Bauer CR, Shankaran S, et al. The Maternal Lifestyles Study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants. Pediatrics. 2002;110:1182–1192
  31. Fried PA, Makin JE. Neonatal behavioral correlates of prenatal exposure to marijuana, cigarettes and alcohol in a low-risk population. Neurotoxicol Teratol. 1987;9:1–7
  32. Coles CD, Platzman KA, Smith I, James ME, Falek A. Effects of cocaine and alcohol use in pregnancy on neonatal growth and neurobehavioral status. Neurotoxicol Teratol. 1992;14:23–33
  33. Scher MS, Richardson GA, Coble PA, Day NL, Stoffer DS. The effects of prenatal alcohol and marijuana exposure: disturbances in neonatal sleep cycling and arousal. Pediatr Res. 1988;24:101–105
  34. Tennes K, Avitable N, Blackard C, Boyles C, Hassoun B, Holmes L, et al. Marijuana: prenatal and post-natal exposure in the human. NIDA Res Monogr. 1985;59:48–60
  35. Richardson GA, Day NL, Goldschmidt L. Prenatal alcohol, marijuana, and tobacco use: infant mental and motor development. Neurotoxicol Teratol. 1995;17:479–487
  36. Dreher MC, Nugent K, Hudgins R. Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study. Pediatrics. 1994;93:254–260
  37. Fried PA, Watkinson B. Visuoperceptual functioning differs in 9- to 12-year-olds prenatally exposed to cigarettes and marijuana. Neurotoxicol Teratol. 2000;22:11–20
  38. Goldschmidt L, Day NL, Richardson GA. Effects of prenatal marijuana exposure on child behavior problems at age 10. Neurotoxicol Teratol. 2000;22:325–336

 Fully funded as a thematic project by the State of São Paulo Research Support Foundation (grant 2000/10293-5).

 None of the authors has any conflict of interest to declare.

PII: S0022-3476(06)00799-2

doi: 10.1016/j.jpeds.2006.08.046

The Journal of Pediatrics
Volume 149, Issue 6 , Pages 781-787 , December 2006