The Journal of Pediatrics
Volume 149, Issue 6 , Pages 827-832 , December 2006

The natural history of euthyroid Hashimoto’s thyroiditis in children

  • Giorgio Radetti, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Dr. Giorgio Radetti, Department of Pediatrics, Regional Hospital, Via L Boehler 5, 39100 Bolzano, Italy.
  • ,
  • Elena Gottardi, MD
  • ,
  • Gianni Bona, MD
  • ,
  • Andrea Corrias, MD
  • ,
  • Silvana Salardi, MD
  • ,
  • Sandro Loche, MD
  • ,
  • Study Group for Thyroid Diseases of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)

      Affiliations

    • Members of the Study Group for Thyroid Diseases of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED) are Fabio Buzi (Brescia), Marco Cappa (Roma), Elena Faleschini (Trieste), Edoardo Farinelli (Perugia), Roberto Gastaldi (Genova), Nella Augusta Greggio (Padova), Lorenzo Iughetti (Modena), Daniela Larizza (Pavia), Silvana Lauriola (Verona), Costanzo Mastrangelo (Foggia), Mariacarolina Salerno (Napoli), and Alessandro Salvatoni (Varese)

Received 13 December 2005 ,Revised 25 April 2006 ,Accepted 19 August 2006.

References 

  1. Rallison ML, Dobyns BM, Keating FR, Rall JE, Tyler FH. Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr. 1975;86:675–682
  2. Radetti G, Mazzanti L, Paganini C, Bernasconi S, Russo G, Rigon F, et al. The Italian Study Group for Turner’s Syndrome Frequency, clinical and laboratory features of thyroiditis in girls with Turner’s syndrome. Acta Paediatr. 1995;84:909–912
  3. Gruñeiro de Papendieck L, Jorcansky S, Coco R, Rivarola MA, Bergada C. High incidence of thyroid disturbances in 49 children with Turner syndrome. J Pediatr. 1987;111:258–261
  4. Germain EL, Plotnick LP. Age-related antithyroid antibodies and thyroid abnormalities in Turner syndrome. Acta Paediatr Scand. 1986;75:750–755
  5. Oderda G, Rapa A, Zavallone A, Strigini L, Bona G. Thyroid autoimmunity in childhood celiac disease. J Pediatr Gastroenterol Nutr. 2002;35:704–705
  6. Larizza D, Calcaterra V, De Giacomo C, De Silvestri A, Asti M, Badulli C, et al. Celiac disease in children with autoimmune thyroid disease. J Pediatr. 2001;139:738–740
  7. Radetti G, Paganini C, Gentili L, Bernasconi S, Betterle C, Borkenstein M, et al. Frequency of Hashimoto’s thyroiditis in children with type 1 diabetes mellitus. Acta Diabetol. 1995;32:121–124
  8. Kordonouri O, Klinghammer A, Lang EB, Gruters-Kieslich A, Grabert M, Holl RW. Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey. Diabetes Care. 2002;25:1346–1350
  9. Franzese A, Buono P, Mascolo M, Leo AL, Valerio G. Thyroid autoimmunity starting during the course of type 1 diabetes denotes a subgroup of children with more severe diabetes. Diabetes Care. 2000;23:1201–1202
  10. Sklar CA, Qazi R, David R. Juvenile autoimmune thyroiditis: hormonal status at presentation and after long-term follow-up. Am J Dis Child. 1986;140:877–880
  11. Jaruratanasirikul S, Leethanaporn K, Khuntigij P, Sriplung H. The clinical course of Hashimoto’s thryoiditis in children and adolescents: 6-year longitudinal follow-up. J Pediatr Endocrinol Metab. 2001;14:177–184
  12. Moore DC. Natural course of “subclinical” hypothyroidism in childhood and adolescence. Arch Pediatr Adolesc Med. 1996;150:293–297
  13. Chase HP, Garg SK, Cockerham RS, Wilcox WD, Walravens PA. Thyroid hormone replacement and growth of children with subclinical hypothyroidism and diabetes. Diabetes Med. 1990;7:299–303
  14. Rallison ML, Dobyns BM, Meikle AW, Bishop M, Lyon JL, Stevens W. Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults. Am J Med. 1991;91:363–370
  15. Vitti P, Martino E, Aghini-Lombardi F, Rago T, Antonangeli L, Maccherini D, et al. Thyroid volume measurament by ultrasound in children as a tool for the assessment of mild iodine deficency. J Clin Endocrinol Metab. 1994;79:600–603
  16. Kordonouri O, Hartmann R, Deiss D, Wilms M, Gruters-Kieslich A. Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty. Arch Dis Child. 2005;90:411–414
  17. Diez JJ, Iglesias P. Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. J Clin Endocrinol Metab. 2004;89:4890–4897
  18. Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, et al. Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. J Clin Endocrinol Metab. 2002;87:3221–3226
  19. Bulow Pedersen I, Laurberg P, Knudsen N, Jorgensen T, Perrild H, Ovesen L, et al. A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clin Endocrinol (Oxf). 2005;62:713–720
  20. Schade RO, Owen SG, Smart GA, Hall R. The relation of thyroid autoimmunity to round-cell infiltration of the thyroid gland. J Clin Pathol. 1960;13:499–501
  21. Yoshida H, Amino N, Yagawa K, Uemura K, Satoh M, Miyai K, et al. Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases. J Clin Endocrinol Metab. 1978;46:859–862
  22. Ventura A, Neri E, Ughi C, Leopaldi A, Citta A, Not T. Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease. J Pediatr. 2000;137:263–265
  23. Sategna Guidetti C, Solerio E, Scaglione N, Aimo G, Mengozzi G. Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders. Gut. 2001;49:502–505
  24. Viljamaa M, Kaukinen K, Huhtala H, Kyronpalo S, Rasmussen M, Collin P. Coeliac disease, autoimmune diseases and gluten exposure. Scand J Gastroenterol. 2005;40:437–443
  25. Tanner JM. In: Foetus into man: physical growth from conception to maturity. 2nd edition. Ware, UK: Castlemead Publications; 1989;
  26. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291:228–238
  27. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT American Association of Clinical Endocrinologists American Thyroid Association The Endocrine Society. Consensus statement 1. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. Thyroid. 2005;15:24–28

PII: S0022-3476(06)00798-0

doi: 10.1016/j.jpeds.2006.08.045

The Journal of Pediatrics
Volume 149, Issue 6 , Pages 827-832 , December 2006