The Journal of Pediatrics
Volume 149, Issue 5 , Pages 591-593 , November 2006

Maternal milk IgA and mother-to-child transmission of human immunodeficiency virus: Not a silver spoon

  • Rupert Kaul, MD, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: Rupert Kaul, Clinical Science Division, Medical Sciences Building #6356, University of Toronto, Toronto, Ontario, Canada, M5S1A8.

References 

  1. Embree JE, Njenga S, Datta P, Nagelkerke NJ, Ndinya-Achola JO, Mohammed Z, et al. Risk factors for postnatal mother-child transmission of HIV-1. Aids. 2000;14:2535–2541
  2. John GC, Nduati RW, Mbori-Ngacha DA, Richardson BA, Panteleeff D, Mwatha A, et al. Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections. J Infect Dis. 2001;183:206–212
  3. Nduati R, John G, Mbori-Ngacha D, Richardson B, Overbaugh J, Mwatha A, et al. Effect of breast-feeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA. 2000;283:1167–1174
  4. Richardson BA, John-Stewart GC, Hughes JP, Nduati R, Mbori-Ngacha D, Overbaugh J, et al. Breast-milk infectivity in human immunodeficiency virus type 1–infected mothers. J Infect Dis. 2003;187:736–740
  5. Kuhn L, Stein Z, Susser M. Preventing mother-to-child HIV transmission in the new millennium: the challenge of breast-feeding. Paediatr Perinat Epidemiol. 2004;18:10–16
  6. Rollins N, Meda N, Becquet R, Coutsoudis A, Humphrey J, Jeffrey B, et al. Preventing postnatal transmission of HIV-1 through breast-feeding: modifying infant feeding practices. J Acquir Immune Defic Syndr. 2004;35:188–195
  7. Kuhn L, Trabattoni D, Kankasa C, Sinkala M, Lissoni F, Ghosh M, et al. HIV-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants. J Pediatr. 2006;149:611–616
  8. John-Stewart G, Mbori-Ngacha D, Ekpini R, Janoff EN, Nkengasong J, Read JS, et al. Breast-feeding and transmission of HIV-1. J Acquir Immune Defic Syndr. 2004;35:196–202
  9. Kourtis AP, Butera S, Ibegbu C, Belec L, Duerr A. Breast milk and HIV-1: vector of transmission or vehicle of protection?. Lancet Infect Dis. 2003;3:786–793
  10. Kuhn L, Trabattoni D, Kankasa C, Semrau K, Kasonde P, Lissoni F, et al. Alpha-defensins in the prevention of HIV transmission among breast-fed infants. J Acquir Immune Defic Syndr. 2005;39:138–142
  11. Naarding MA, Ludwig IS, Groot F, Berkhout B, Geijtenbeek TB, Pollakis G, et al. Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes. J Clin Invest. 2005;115:3256–3264
  12. Bouhlal H, Latry V, Requena M, Aubry S, Kaveri SV, Kazatchkine MD, et al. Natural antibodies to CCR5 from breast milk block infection of macrophages and dendritic cells with primary R5-tropic HIV-1. J Immunol. 2005;174:7202–7209
  13. Groot F, Geijtenbeek TB, Sanders RW, Baldwin CE, Sanchez-Hernandez M, Floris R, et al. Lactoferrin prevents dendritic cell–mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN–gp120 interaction. J Virol. 2005;79:3009–3015
  14. Broliden K, Hinkula J, Devito C, Kiama P, Kimani J, Trabbatoni D, et al. Functional HIV-1–specific IgA antibodies in HIV-1–exposed, persistently IgG-seronegative female sex workers. Immunol Lett. 2001;79:29–36
  15. Becquart P, Hocini H, Levy M, Sepou A, Kazatchkine MD, Belec L. Secretory anti-human immunodeficiency virus (HIV) antibodies in colostrum and breast milk are not a major determinant of the protection of early postnatal transmission of HIV. J Infect Dis. 2000;181:532–539
  16. Wright PF, Kozlowski PA, Rybczyk GK, Goepfert P, Staats HF, VanCott TC, et al. Detection of mucosal antibodies in HIV type 1–infected individuals. AIDS Res Hum Retroviruses. 2002;18:1291–1300
  17. Phalipon A, Cardona A, Kraehenbuhl JP, Edelman L, Sansonetti PJ, Corthesy B. Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity. 2002;17:107–115
  18. Wei X, Decker JM, Wang S, Hui H, Kappes JC, Wu X, et al. Antibody neutralization and escape by HIV-1. Nature. 2003;422:307–312

PII: S0022-3476(06)00787-6

doi: 10.1016/j.jpeds.2006.08.024

The Journal of Pediatrics
Volume 149, Issue 5 , Pages 591-593 , November 2006

Article Tools