The Journal of Pediatrics
Volume 149, Issue 4 , Pages 436-438 , October 2006

Gastroesophageal reflux: Not a time to “relax”

  • Carlo Di Lorenzo, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Dr Carlo Di Lorenzo, Department of Pediatric Gastroenterology, Children’s Hospital of Columbus, 700 Children’s Drive, Columbus, OH 43205.

References 

  1. Kawahara H, Dent J, Davidson G. Mechanisms responsible for gastroesophageal reflux in children. Gastroenterology. 1997;113:399–408
  2. Bines JE, Quinlan JE, Treves S, Kleinman RE, Winter HS. Efficacy of domperidone in infants and children with gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 1992;14:400–405
  3. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, et al. North American Society for Pediatric Gastroenterology and Nutrition Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001;32(suppl 2):S1–S31
  4. Vela MF, Camacho-Lobato L, Srinivasan R, Tutuian R, Katz PO, Castell DO. Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. Gastroenterology. 2001;120:1599–1606
  5. Gold BD. Is gastroesophageal reflux disease really a life-long disease: do babies who regurgitate grow up to be adults with GERD complications?. Am J Gastroenterol. 2006;101:641–644
  6. Raghunath AS, O’Morain C, McLoughlin RC. Review article: the long-term use of proton-pump inhibitors. Aliment Pharmacol Ther. 2005;22(suppl 1):55–63
  7. Holloway RH. Treatment of gastro-oesophageal reflux disease through control of transient lower oesophageal sphincter relaxations--feasibility, practicality and possibilities. Dig Liver Dis. 2000;32:183–187
  8. Boeckxstaens GE. The lower oesophageal sphincter. Neurogastroenterol Motil. 2005;17(suppl 1):13–21
  9. Omari TI, Benninga MA, Sansom L, Butler RN, Dent J, Davidson GP. Effect of baclofen on esophago-gastric motility and gastroesophageal reflux in children with GERD: a randomized controlled trial. J Pediatr. 2006;149:468–474
  10. Partosoedarso ER, Young RL, Blackshaw LA. GABA(B) receptors on vagal afferent pathways: peripheral and central inhibition. Am J Physiol Gastrointest Liver Physiol. 2001;280:G65–G68
  11. Vela MF, Tutuian R, Katz PO, Castell DO. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther. 2003;17:243–251
  12. Bettler B, Kaupmann K, Mosbacher J, Gassmann M. Molecular structure and physiological functions of GABA(B) receptors. Physiol Rev. 2004;84:835–867

PII: S0022-3476(06)00688-3

doi: 10.1016/j.jpeds.2006.07.028

The Journal of Pediatrics
Volume 149, Issue 4 , Pages 436-438 , October 2006

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