The Journal of Pediatrics
Volume 149, Issue 4 , Pages 448-451, October 2006

New rotavirus vaccines: Renewed optimism

  • Miguel O’Ryan, MD

      Affiliations

    • Dr O’Ryan was the principal investigator for the Multicenter Human Rotavirus Vaccine Trial sponsored by GlaxoSmithKline Biologicals. Dr O’Ryan has received consulting and lecture fees from GlaxoSmithKline Biologicals.
    • Corresponding Author InformationReprint requests: Dr Miguel O’Ryan, University of Chile, Department of Microbiology, Unidad Oriente, Facultad de Medicina, Santiago, Chile.
    • ,
  • David O. Matson, MD, PhD

      Affiliations

    • Dr Matson was the principal investigator in the US for the Multicenter Bovine-Human Pentavalent Reassortant Vaccine Trial sponsored by Merck and Co. Dr Matson has received grant support and consulting fees from Merck and Co.

Institute of Biomedical Sciences, Faculty of Medicine, University of Chile; and the Infectious Diseases Section, Center for Pediatric Research, Eastern Virginia Medical School, Norfolk, Virginia.

Received 3 March 2006; received in revised form 9 May 2006; accepted 11 July 2006.

Soon after the discovery of rotavirus (RV) in 1973, it became clear that this virus caused a significant proportion of diarrheal episodes affecting young children worldwide. This early appreciation prompted interest in developing vaccines in the 1980s and spurred investigation of unsolved issues associated with the epidemiology, molecular epidemiology, and immunology of RV infections.

See related articles, p 441 and p 452

Abbreviations: RRV-TV, Human-rhesus vaccine, RV, Rotavirus

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PII: S0022-3476(06)00682-2

doi:10.1016/j.jpeds.2006.07.018

Refers to article:

  • Nosocomial rotavirus infections: A systematic review

    Aruna Chandran, Rebekah R. Heinzen, Mathuram Santosham, George K. Siberry
    The Journal of Pediatrics October 2006 (Vol. 149, Issue 4, Pages 441-447)

  • Risk factors for intussusception in infants in Vietnam and Australia: Adenovirus implicated, but not rotavirus

    Julie E. Bines, Nguyen Thanh Liem, Frances A. Justice, Tran Ngoc Son, Carl D. Kirkwood, Margaret de Campo, Peter Barnett, Ruth F. Bishop, Roy Robins-Browne, John B. Carlin, Intussusception Study Group
    The Journal of Pediatrics October 2006 (Vol. 149, Issue 4, Pages 452-460.e1)

The Journal of Pediatrics
Volume 149, Issue 4 , Pages 448-451, October 2006

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