The Journal of Pediatrics
Volume 149, Issue 5, Supplement , Pages S97-S99 , November 2006

Obesity as a consequence of undernutrition

Presented as part of a symposium recognizing the 25th anniversary of the Bristol-Myers Squibb Freedom to Discover Nutrition Grants Program held June 7-8, 2005 at the University of Cincinnati, Cincinnati, OH.

  • Benjamin Caballero, MD, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: Benjamin Caballero, MD, PhD, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Baltimore, MD 21205.

Received 14 April 2006 ,Accepted 1 June 2006.

References 

  1. Williams CD. A nutritional disease of childhood associated with a maize diet. Arch Dis Child. 1933;8:423–433
  2. Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976;295:349–353
  3. Ravelli AC, Der Meulen JH, Osmond C, Barker DJ, Bleker OP. Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr. 1999;70:811–816
  4. Barker M, Robinson S, Osmond C, Barker DJ. Birth weight and body fat distribution in adolescent girls. Arch Dis Child. 1997;77:381–383
  5. Law CM, Barker DJP, Osmond C, Fall CH. Early growth and abdominal fatness in adult life. J Epidemiol Comm Health. 1992;46:184–186
  6. Rogers I. The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord. 2003;27:755–777
  7. Valdez R, Athens MA, Thompson GH, Bradshaw BS, Stern MP. Birthweight and adult health outcomes in a biethnic population in the USA. Diabetologia. 1994;37:624–631
  8. Malina RM, Katzmarzyk PT, Beunen G. Birth weight and its relationship to size attained and relative fat distribution at 7 to 12 years of age. Obes Res. 1996;4:385–390
  9. Beunen G, Malina RM, Lefevre J, Claessens AL, Renson R, Simons J, et al. Size, fatness and relative fat distribution of males of contrasting maturity status during adolescence and as adults. Int J Obes Relat Metab Disord. 1994;18:670–678
  10. Jones AP, Friedman MI. Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy. Science. 1982;215(4539):1518–1519
  11. Kind KL, Roberts CT, Sohlstrom AI, Katsman A, Clifton PM, Robinson JS, et al. Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig. Am J Physiol Regul Integr Comp Physiol. 2005;288:R119–R126
  12. Yajnik CS, Fall CH, Coyaji KJ, Hirve SS, Rao S, Barker DJ, et al. Neonatal anthropometry: the thin-fat Indian baby (The Pune maternal nutrition study). Int J Obes Relat Metab Disord. 2003;27:173–180
  13. Yajnik CS. Early life origins of insulin resistance and type 2 diabetes in India and other Asian countries. J Nutr. 2004;134:205–210
  14. Singhal A, Wells J, Cole TJ, Fewtrell M, Lucas A. Programming of lean body mass: a link between birth weight, obesity, and cardiovascular disease?. Am J Clin Nutr. 2003;77:726–730
  15. Hoffman DJ, Sawaya AL, Verreschi I, Tucker KL, Roberts SB. Why are nutritionally stunted children at increased risk of obesity? (Studies of metabolic rate and fat oxidation in shantytown children from Sao Paulo, Brazil). Am J Clin Nutr. 2000;72:702–707
  16. Jones CT, Lafeber HN, Rolph TP, Parer JT. Studies on the growth of the fetal guinea pig (The effects of nutritional manipulation on prenatal growth and plasma somatomedin activity and insulin-like growth factor concentrations). J Dev Physiol. 1990;13:189–197
  17. Yajnik CS, Lubree HG, Rege SS, Naik SS, Deshpande JA, Deshpande SS, et al. Adiposity and hyperinsulinemia in Indians are present at birth. J Clin Endocrinol Metab. 2002;87:5575–5580
  18. Vickers MH, Breier BH, Cutfield WS, Hofman PL, Gluckman PD. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab. 2000;279:E83–E87
  19. Jones AP, Simson EL, Friedman MI. Gestational undernutrition and the development of obesity in rats. J Nutr. 1984;114:1484–1492
  20. Desai M, Gayle D, Babu J, Ross MG. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition. Am J Physiol Regul Integr Comp Physiol. 2005;288:R91–R96
  21. Popkin BM. The nutrition transition and obesity in the developing world. J Nutr. 2001;131:871S–873S
  22. Monteiro CA, Conde WL, Popkin BM. The burden of disease from undernutrition and overnutrition in countries undergoing rapid nutrition transition: a view from Brazil. Am J Public Health. 2004;94:433–434
  23. Mendez MA, Monteiro CA, Popkin BM. Overweight exceeds underweight among women in most developing countries. Am J Clin Nutr. 2005;81:714–721
  24. Caballero B, Popkin BM. The nutrition transition: diet and disease in the developing world. London: Academic Press; 2002;
  25. Caballero B. A nutrition paradox: underweight and obesity in developing countries. N Engl J Med. 2005;352:1514–1516
  26. Caballero B. Obesity in developing countries: biological and ecological factors. J Nutr. 2001;131:866S–870S

PII: S0022-3476(06)00619-6

doi: 10.1016/j.jpeds.2006.06.059

The Journal of Pediatrics
Volume 149, Issue 5, Supplement , Pages S97-S99 , November 2006

Article Tools

* Image Usage & Resolution