The Journal of Pediatrics
Volume 149, Issue 5, Supplement , Pages S64-S68 , November 2006

Changes in zinc absorption during development

Presented as part of a symposium recognizing the 25th anniversary of the Bristol-Myers Squibb Freedom to Discover Nutrition Grants Program, held June 7-8, 2005, at the University of Cincinnati, Cincinnati, OH.

Received 14 April 2006 ,Accepted 1 June 2006.

References 

  1. Hambidge M. Human zinc deficiency. J Nutr. 2000;130(5S Suppl):1344–1349S
  2. International Zinc Nutrition Consultative Group. In: Assessment of the risk of zinc status in populations and options for the control of zinc deficiency. Boston: International Nutrition Foundation for United Nations University Press; 2004;
  3. Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr. 1999;135:689–697
  4. Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr. 2000;72:1516–1522
  5. Jones G, Steketee RW, Black RE, Bhutta ZA, Morris SS. How many child deaths can we prevent this year?. Lancet. 2003;362:65–71
  6. Black RE. Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. Am J Clin Nutr. 1998;68(2 Suppl):476–479S
  7. Walravens PA, Hambidge KM. Growth of infants fed a zinc supplemented formula. Am J Clin Nutr. 1976;29:1114–1121
  8. Walravens PA, Hambidge KM, Koepfer DM. Zinc supplementation in infants with a nutritional pattern of failure to thrive: a double-blind, controlled study. Pediatrics. 1989;83:532–538
  9. Krebs NF, Westcott J. Zinc and breastfed infants: if and when is there a risk of deficiency?. In:  Davis MK,  Isaacs CE,  Hanson LA,  Wright AL editor. Integrating population outcomes, biological mechanisms and research methods in the study of human milk and lactation. New York: Kluwer Academic/Plenum Press; 2002;p. 69–76
  10. Walravens PA, Chakar A, Mokni R, Denise J, Lemonnier D. Zinc supplements in breastfed infants. Lancet. 1992;340:683–685
  11. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132(6 Suppl 1):1395–1577S
  12. Friel JK, Andrews WL, Matthew JD, Long DR, Cornel AM, Cox M, et al. Zinc supplementation in very-low-birth-weight infants. J Pediatr Gastroenterol Nutr. 1993;17:97–104
  13. Kelleher SL, Boshuslav D, Hall AC, Philipps AF, Lonnerdal B. Infant small intestine Zn transporter expression is altered during Zn deficiency. FASEB J. 2005;19:A457
  14. Dufner-Beattie J, Wang F, Kuo YM, Gitschier J, Eide D, Andrews GK. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. J Biol Chem. 2003;278:33474–33481
  15. Hambidge KM, Miller LV, Tran CD, Krebs NF. Measurements of zinc absorption: application and interpretation in studies designed to improve human zinc nutriture. Int J Vit Nutr Res. 2005;75:385–393
  16. Krebs NF, Hambidge KM. Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiology. Biometals. 2001;2001:397–412
  17. World Health Organization. In: Trace elements in human nutrition and health. Geneva: WHO; 1996;
  18. Food and Nutrition Board, Institute of Medicine. In: Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. Washington, DC: National Academy Press; 2001;
  19. Steele L, Cousins RJ. Kinetics of zinc absorption by luminally and vascularly perfused rat intestine. Am J Physiol. 1985;248:G46–G53
  20. Hambidge KM, Krebs NF. Interrelationships of key variables of human zinc homeostasis: relevance to dietary zinc requirements. Ann Rev Nutr. 2001;21:429–452
  21. Sian L, Mingyan X, Miller LV, Tong L, Krebs NF, Hambidge KM. Zinc absorption and intestinal losses of endogenous zinc in young Chinese women with marginal zinc intakes. Am J Clin Nutr. 1996;63:348–353
  22. Motulsky H, Christopoulos A. In: Fitting models to biological data using non-linear regression. A practical guide to curve fitting. San Diego: Graph Pad Software; 2003;
  23. Weaver LT, Austin S, Cole TJ. Small intestinal length: a factor essential for gut adaptation. Gut. 1991;32:1321–1323
  24. Jalla S, Krebs NF, Rodden D, Hambidge KM. Zinc homeostasis in premature infants does not differ between those fed preterm formula or fortified human milk. Pediatr Res. 2004;56:615–620
  25. Ehrenkranz RA, Gettner PA, Nelli CM, Sherwonit EA, Williams JE, Ting BT, et al. Zinc and copper nutritional studies in very low birth weight infants: comparison of stable isotopic extrinsic tag and chemical balance methods. Pediatr Res. 1989;26:298–307
  26. Ziegler EE, Serfass RE, Nelson SE, Figueroa-Colon R, Edwards BB, Houk RS, et al. Effect of low zinc intake on absorption and excretion of zinc by infants studied with 70Zn as extrinsic tag. J Nutr. 1989;119:1647–1653(11)
  27. Krebs NF, Reidinger CJ, Miller LV, Hambidge KM. Zinc homeostasis in breast-fed infants. Pediatr Res. 1996;39:661–665(4 Pt 1)
  28. Krebs N, Reidinger CJ, Miller LV, Borschel M. Zinc homeostasis in normal infants fed a casein hydrolysate formula. J Pediatr Gastro Nutr. 2000;30:29–33
  29. Krebs NF, Steirn M, Westcott JE. High iron (Fe) formula associated with lower zinc (Zn) absorption in breastfed infants. Pediatr Res. 2000;130:204A

 Supported in part by National Institutes of Health Global Network (U01 HD40657) and National Institutes of Health K24 (Krebs; RR018357). Studies, results of which have contributed to this paper have been supported in part by Mead Johnson and Company, Ross Products, a division of Ross Laboratories, and the Pediatric General Clinical Research Centers Program (M01 RR00069). Dr Hambidge prepared the first draft of the paper without any honorarium, grant or other form of payment to produce the paper.Mead Johnson sponsored the symposium, and provided an honorarium for conference attendance, presentation of the paper and submission of a manuscript. The authors are entirely and exclusively responsible for its content.

PII: S0022-3476(06)00614-7

doi: 10.1016/j.jpeds.2006.06.054

The Journal of Pediatrics
Volume 149, Issue 5, Supplement , Pages S64-S68 , November 2006

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