Effects of sickle cell disease on the heart and lung

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Some effects of sickle cell disease in childhood are well known. These include painful crises, increased risk of infection, and cerebrovascular disease. The effects of sickle cell disease on the heart and lung have been less well studied. Two studies address these issues. Qureshi et al found evidence of increased pulmonary vascular resistance and right ventricular mass. This suggests that in some patients with sickle cell disease, pulmonary hypertension is developing over time. Sylvester et al evaluated the impact of episodes of acute chest syndrome on lung function. They report that children who have had an episode of acute chest syndrome have diminished lung function, suggesting increased obstruction of airways. In an editorial, Boyd et al urged closer follow-up of cardiac and pulmonary abnormalities over time to promote optimum health for patients with sickle cell disease as they make the transition from childhood to adulthood.