The Journal of Pediatrics
Volume 149, Issue 2 , Pages 156-158 , August 2006

No the evidence: What have measurements of exhaled nitric oxide got to offer?

  • Louise Fleming, MRCPCH
    • ,
  • Nicola Wilson, MD, FRCPCH
    • ,
  • Andrew Bush, MB, BS (Hons), MA, MD, FRCP, FRCPCH

      Affiliations

    • Corresponding Author InformationReprint requests: Professor Andrew Bush, Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

References 

  1. Kharitonov S , Yates D , Robbins RA , Logan Sinclair R , Shinebourne EA , Barnes PJ , et al.   Increased nitric oxide in exhaled air of asthmatic patients . Lancet . 1994;343:133–135
  2. Byrnes CA , Denarevic S , Shinebourne EA , Barnes PJ , Bush A . Exhaled nitric oxide measurements in normal and asthmatic children . Pediatr Pulmonol . 1997;24:312–318
  3. British guideline on the management of asthma . Thorax . 2003;58(Suppl 1):S1–S94
  4. Todd GR , Acerini CL , Ross-Russell R , Zahra S , Warner JT , McCance D . Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom . Arch Dis Child . 2002;87:457–461
  5. Green RH , Brightling CE , McKenna S , Hargadon B , Parker D , Bradding P , et al.   Asthma exacerbations and sputum eosinophil counts (a randomised controlled trial) . Lancet . 2002;360:1715–1721
  6. Pijnenburg MW , Bakker EM , Hop WC , De Jongste JC . Titrating steroids on exhaled nitric oxide in children with asthma (a randomized controlled trial) . Am J Respir Crit Care Med . 2005;172:831–836
  7. Pijnenburg MW , Hofhuis W , Hop WC , De Jongste JC . Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission . Thorax . 2005;60:215–218
  8. Zacharasiewicz A , Wilson N , Lex C , Erin EM , Li AM , Hansel T , et al.   Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children . Am J Respir Crit Care Med . 2005;171:1077–1082
  9. Pijnenburg MW , Bakker EM , Lever S , Hop WC , De Jongste JC . High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children . Clin Exp Allergy . 2005;35:920–925
  10. Lex C , Ferreira F , Payne DNR , Zacharasiewicz A , Nicholson A , Haslam P . Comparison of noninvasive and invasive methods for assessment of airway inflammation in children with asthma . Thorax . 2003;58:iii61; SIII
  11. van den Toorn LM , Overbeek SE , de Jongste JC , Leman K , Hoogsteden HC , Prins JB . Airway inflammation is present during clinical remission of atopic asthma . Am J Respir Crit Care Med . 2001;164:2107–2113
  12. Baraldi E , de Jongste JC  European Respiratory Society  American Thoracic Society . ERS/ATS Statement. Measurement of exhaled nitric oxide in children . Eur Respir J . 2002;20:223–237
  13. Piacentini GL , Bodini A , Costella S , Vincentini I , Mazzi P , Speradis S , et al.   Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children . Eur Respir J . 1999;13:1386–1390
  14. Lex C , Payne DN , Zacharasiewicz A , Li AM , Wilson NM , Hansel TT , et al.   Sputum induction in children with difficult asthma (safety, feasibility, and inflammatory cell pattern) . Pediatr Pulmonol . 2005;39:318–324
  15. Proud D . Nitric oxide and the common cold . Curr Opin Allergy Clin Immunol . 2005;5:37–42
  16. Spanier AJ , Horung R , Lierl M , Lanphear BP . Environmental exposure and exhaled nitric oxide in children with asthma . J Pediatr . 2006;149:220–226
  17. Sulakvelidze I , Inman MD , Rerecich T , O’Byrne PM . Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low-dose allergen challenge in atopic asthmatics . Eur Respir J . 1998;11:821–827
  18. Nimmagadda SR , Szefler SJ , Spahn JD , Surs W , Leung DYM . Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics . Am Rev Respir Crit Care Med . 1997;155:87–93
  19. Torrego A , Pujols L , Roca-Ferrer J , Mullol J , Xaubet A , Picado C . Glucocorticoid receptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity . Am J Respir Crit Care Med . 2004;170:420–428
  20. Langley SJ , Goldthorpe S , Craven M , Woodcock A , Custovic A . Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects . Thorax . 2005;60:17–21
  21. Green RM , Custovic A , Sanderson G , Hunter J , Johnston SL , Woodcock A . Synergism between allergens and viruses and risk of hospital admission with asthma (case-control study) . Br Med J . 2002;324:763–766
  22. Murray CS , Poletti G , Kebadze T , Morris J , Woodcock A , Johnston S . A study of modifiable risk factors for asthma exacerbations (virus infection and allergen exposure increase the risk of asthma hospitalization in children) . Thorax . 2006;61:376–382
  23. Chalmers GW , Macleod KJ , Little SA , Thomson LJ , McSharry CP , Thomson NC . Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma . Thorax . 2002;57:226–230
  24. Chaudhuri R , Livingston E , McMahon AD , Thomson L , Borland W , Thomson NC . Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma . Am J Respir Crit Care Med . 2003;168:1308–1311

PII: S0022-3476(06)00484-7

doi: 10.1016/j.jpeds.2006.05.035

The Journal of Pediatrics
Volume 149, Issue 2 , Pages 156-158 , August 2006

Article Tools