The Journal of Pediatrics
Volume 149, Issue 4 , Pages 480-485 , October 2006

Polymerase chain reaction diagnosis of primary human herpesvirus-6 infection in the acute care setting

Received 7 November 2005 ,Revised 15 March 2006 ,Accepted 17 May 2006.

References 

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  2. Okuno T, Takahashi K, Balachandra K, Shiraki K, Yamanishi K, Takahashi M, et al. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol. 1989;27:651–653
  3. Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang M, Wald A, et al. Virologic and clinical characteristics of primary human herpesvirus 6: a population-based study. N Engl J Med. 2005;352:768–776
  4. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, et al. Human herpesvirus-6 infection in children: a prospective study of complications and reactivation. N Engl J Med. 1994;331:432–438
  5. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, et al. Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis. 1995;171:273–280
  6. Clark DA, Kidd IM, Collingham KE, Tarlow M, Ayeni T, Riordan A, et al. Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction. Arch Dis Child. 1997;77:42–45
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  8. Chiu SS, Cheung CY, Tse CY, Peiris M. Early diagnosis of primary human herpesvirus 6 infection in childhood: serology, polymerase chain reaction, and virus load. J Infect Dis. 1998;178:1250–1256
  9. Suga S, Yoshikawa T, Kajita Y, Ozaki T, Asano Y. Prospective study of persistence and excretion of human herpesvirus-6 in patients with exanthem subitum and their parents. Pediatrics. 1998;102:900–904
  10. Ryncarz AJ, Goddard J, Wald A, Huang ML, Roizman B, Corey L. Development of a high-throughput quantitative assay for detecting herpes simplex virus DNA in clinical samples. J Clin Microbiol. 1999;37:1941–1947
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 This clinical research was conducted in accordance with guidelines for human experimentation as specified by the Children’s Hospital Institutional Review Board.None of the authors has any potential conflict of interest, real or perceived.Supported by in part by National Institutes of Health grant K23 AI001679 and by a grant from Children’s Hospital Fund for Excellence.

PII: S0022-3476(06)00467-7

doi: 10.1016/j.jpeds.2006.05.027

The Journal of Pediatrics
Volume 149, Issue 4 , Pages 480-485 , October 2006

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