The Journal of Pediatrics
Volume 149, Issue 3 , Pages 324-329 , September 2006

Growth hormone deficiency, low levels of adiponectin, and unfavorable plasma lipid and lipoproteins

Received 18 January 2006 ,Revised 1 March 2006 ,Accepted 9 May 2006.

References 

  1. Kershaw EE , Flier JS . Adipose tissue as an endocrine organ . J Clin Endocrinol Metab . 2004;89:2548–2556
  2. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsusawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes (close association with insulin resistance and hyperinsulinemia) . J Clin Endocrinol Metab . 2001;86:1930–1935
  3. Matsubara M , Maruoka S , Katayose S . Decreased plasma adiponectin concentrations in women with dyslipidemia . J Clin Endocrinol Metab . 2002;87:2764–2769
  4. Adamczak M , Wiecek A , Funahashi T , Chudek J , Kokot F , Matsuzawa Y . Decreased plasma adiponectin concentrations in patients with essential hypertension . Am J Hypertens . 2003;16:72–75
  5. Shimada K , Miyazaki T , Daida H . Adiponectin and atheroslerotic disease . Clin Chim Acta . 2004;344:1–12
  6. Eden Engstrom B , Burman P , Holdstock C , Karlsson F . Effects of growth hormone (GH) on ghrelin, leptin and adiponectin in GH-deficient patients . J Clin Endocrinol Metab . 2003;88:5193–5198
  7. Giavoli C , Capiello V , Corbetta S , Ronchi CL , Morpurgo PS , Ferrante E , et al.   Different effects of short and long term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adults . Clin Endocrinol . 2004;61:81–87
  8. Hana V , Silha J , Justova V , Lacinova Z , Stepan J , Murphy I . The effects of GH replacement in adult GH-deficient patients (changes in body composition without concomitanmt changes in adipokines and insulin resistance) . Clin Endocrinol (Oxf) . 2004;60:442–450
  9. Svensson J , Herlitz H , Lungberg PA , Johansson G . Adiponectin, leptin and erythrocyte sodium/lithium countertransport activity, but not resistin, are related to glucose metabolism in growth hormone-deficient adults . J Clin Endocrinol Metab . 2005;90:2290–2296
  10. Pilz S , Horejsi R , Moller R , Almer G , Scharnagl H , Stojakovic T , et al.   Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin . J Clin Endocrinol Metab . 2005;90:4792–4796
  11. Mangge H , Schaenstein K , Stroedter L , Griesl A , Maerz W , Borkenstein M . Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis . Exp Clin Endocrinol Diabetes . 2004;112:378–382
  12. Kuromaru R , Kohno H , Ueyama N , Hassan HMS , Hara T . Long-term prospective study of body composition and lipid profiles during and after growth hormone (GH) treatment in children with GH deficiency (gender-specific metabolic effects) . J Clin Endocrinol Metab . 1998;83:3890–3896
  13. Johannsson G , Albertsson-Wikland K . Discontinuation of growth hormone (GH) treatment (metabolic effects in GH-deficient and GH-suficient adolescent patients compared with control subjects) . J Clin Endocrinol Metab . 1999;84:4516–4524
  14. Lanes R , Gunczler P , Lopez E , Esaa S , Villaroel O , Revel-Chion R . Cardiac mass and function, carotid artery intima-media thickness and lipoprotein levels in growth hormone deficient adolescents . J Clin Endocrinol Metab . 2001;86:1061–1065
  15. Lanes R , Paoli M , Carrillo E , Villaroel O , Palacios A . The cardiovascular risk of young growth hormone deficient adolescents (differences in growth hormone treated and untreated subjects) . Horm Res . 2003;60:291–295
  16. Lanes R , Paoli M , Carrillo E , Villaroel O , Palacios A . Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency. Relation to postprandial dyslipidemia . J Pediatr . 2004;145:657–661
  17. Husbands S , Ong KKL , Gilbert J , Wass JAH , Dunger DB . Increased insulin sensitivity in young, growth hormone deficient children . Clin Endocrinol . 2001;55:87–92
  18. Lanes R , Soros A , Flores K , Gunczler P , Carrillo E , Bandel J . Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue and left ventricular mass and function in growth hormone deficient adolescents . J Clin Endocrinol Metab . 2005;90:3978–3982
  19. Lanes R , Recker B , Fort P , Lifshitz F . Low dose oral clonidine (a simple and reliable growth hormone screening test for children) . Am J Dis Child . 1985;139:87–89
  20. Donnadieu M , Evain-Brion D , Tonon MC , Vaudry H , Job JC . Variations of plasma growth hormone (GH)-releasing factor levels during GH stimulation tests in children . J Clin Endocrinol Metab . 1985;60:1132–1134
  21. Kumada M , Kihara S , Sumitsuji S , Kawamoto T , Matsumoto S , Ouchi N , et al.   Association of hypoadiponectinemia with coronary artery disease in men . Arterioscler Thromb Vasc Biol . 2003;23:85–89
  22. Shimabukuro M , Higa N , Asahi T , Oshiro Y , Takasu N , Tagawa T , et al.   Hypoadiponectinemia is closely linked to endothelial dysfunction in man . J Clin Endocrinol Metab . 2003;88:3236–3240
  23. Cote M, Mauriege P, Bergeron J, Almeras N, Tremblay A, Lemieux I, et al. Adiponectinemia in visceral obesity (impact on glucose tolerance and plasma lipoprotein and lipid levels) . J Clin Endocrinol Metab . 2005;90:1434–1439
  24. Maison P , Griffin S , Nicoue-Beglah M , Haddad N , Balkau B , Chanson P . Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults (a metaanalysis of blinded, randomized, placebo-controlled trials) . J Clin Endocrinol Metab . 2004;89:2192–2199
  25. Smith JC, Evans LM, Wilkinson I, Goodfellow J, Cockcroft JR, Scanlon MF, et al. Effects of GH replacement on endothelial function and large-artery stiffness in GH-deficient adults; a randomized, double-blind, placebo-controlled study . Clin Endocrinol . 2002;5:493–501
  26. Combs TP , Berg AH , Obici S , Scherer PE , Rossetti L . Endogenous glucose production is inhibited by the adipose-derived protein Acrp30 . J Clin Invest . 2001;108:1875–1881
  27. Weiss R , Dufour S , Groszmann A , Petersen K , Dziura J , Taksali SE , et al.   Low adiponectin levels in adolescent obesity (a marker of increased intramyocellular lipid accumulation) . J Clin Endocrinol Metab . 2003;88:2014–2018
  28. Pajvani UB , Scherer PE . Adiponectin (systemic contributor to insulin sensitivity) . Curr Diab Rep . 2003;3:207–213
  29. Yamauchi T , Kamon J , Minokoshi Y . Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase . Nat Med . 2002;8:1288–1295
  30. Cummings MH , Christ E , Umpleby AM , Albany E , Wierzbicki A , Lumb PJ , et al.   Abnormalities of very low density lipoprotein apolipoprotein B-100 metabolism contribute to the dyslipidemia of adult growth hormone deficiency . J Clin Endocrinol Metab . 1997;82:2010–2013
  31. Kissebah AH , Krakower GR . Regional adiposity and morbidity . Physiol Rev . 1994;74:761–811
  32. Murray RD , Wieringa GE , Lissett CA , Daerzy KH , Smethurst LE , Shalet SM . Low-dose GH replacement improves the adverse lipid profile associated with the adult GH deficiency syndrome . Clin Endocrinol . 2002;56:525–532
  33. Beshyah SA, Henderson A, Niththyananthan R, Skinner E, Anyaoku V, Richmond W, et al. The effects of short and long term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance . J Clin Endocrinol Metab . 1995;80:356–363

 We thank Pfizer of Venezuela for the generous contribution, which allowed us to purchase the laboratory materials for this study.

PII: S0022-3476(06)00445-8

doi: 10.1016/j.jpeds.2006.05.010

The Journal of Pediatrics
Volume 149, Issue 3 , Pages 324-329 , September 2006