The Journal of Pediatrics
Volume 149, Issue 1 , Pages 3-4 , July 2006

The outcomes of sickle cell disease in adulthood are clear, but the origins and progression of sickle cell anemia-induced problems in the heart and lung in childhood are not

  • Jessica H. Boyd, MD

      Affiliations

    • Department of Pediatrics, Washington University, St. Louis, MO
    • ,
  • Robert C. Strunk, MD

      Affiliations

    • Department of Pediatrics, Washington University, St. Louis, MO
    • ,
  • Wayne J. Morgan, MD, CM

      Affiliations

    • Department of Pediatrics and Arizona Respiratory Center, University of Arizona, Tucson, AZ
    • Corresponding Author InformationReprint requests: Dr Wayne J. Morgan, Department of Pediatrics, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724.

References 

  1. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, et al. Mortality in sickle cell disease. Life expectancy and risk factors for early death . New Engl J Med . 1994;330:1639–1644
  2. Powars D , Weidman JA , Odom-Maryon T , Niland JC , Johnson C . Sickle cell chronic lung disease (prior morbidity and the risk of pulmonary failure) . Medicine . 1988;67:66–76
  3. Gladwin MT , Sachdev V , Jison ML , Shizukuda Y , Plehn JF , Minter K , et al.   Pulmonary hypertension as a risk factor for death in patients with sickle cell disease . New Engl J Med . 2004;350:886–895
  4. Miller GJ , Sergeant GR . An assessment of lung volumes and gas transfer in sickle-cell anaemia . Thorax . 1971;26:309–315
  5. Santoli F , Zerah F , Vasile N , Bachir D , Galacteros F , Atlan G . Pulmonary function in sickle cell disease with or without acute chest syndrome . Eur Respir J . 1998;12:1124–1129
  6. Pianosi P , D’Souza JA , Charge TD , Esseltine DE , Coates AL . Pulmonary function abnormalities in childhood sickle cell disease . J Pediatr . 1993;122:366–371
  7. Koumbourlis AC , Zar HJ , Hurlet-Jensen A , Goldberg MR . Prevalence and reversibility of lower airway obstruction in children with sickle cell disease . J Pediatr . 2001;132:188–192
  8. Qureshi N , Joyce JJ , Ning Qi N , Chang RK . Right ventricular abnormalities in sickle cell anemia (evidence of a progressive increase in pulmonary vascular resistance) . J Pediatr . 2006;149:23–27
  9. Machado RF , Martyr S , Kato GJ , Barst RJ , Anthi A , Robinson MR , et al.   Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension . Br J Hematol . 2005;130:445–453
  10. Sylvester KP , Patey RA , Milligan P , Rafferty GF , Broughton S , Rees D , et al.   Impact of acute chest syndrome on lung function of children with sickle cell disease . J Pediatr . 2006;149:17–22
  11. Boyd JH , Moinuddin A , Strunk RC , DeBaun MR . Asthma and acute chest in sickle cell disease . Pediatr Pulmonol . 2004;38:229–232
  12. Knight-Madden JM , Forrester TS , Lewis NA , Greenough A . Asthma in children with sickle cell disease and its association with acute chest syndrome . Thorax . 2005;60:206–210
  13. Leong MA , Dampier C , Varlotta L , Allen JL . Airway hyperreactivity in children with sickle cell disease . J Pediatr . 1997;131:278–283
  14. Morgan WJ , Stern DA , Sherrill DL , Guerra S , Holberg CJ , Guilbert TW , et al.   Outcome of asthma and wheezing in the first 6 years of life (follow-up through adolescence) . Am J Respir Crit Care Med . 2005;172:1253–1258

PII: S0022-3476(06)00390-8

doi: 10.1016/j.jpeds.2006.04.056

The Journal of Pediatrics
Volume 149, Issue 1 , Pages 3-4 , July 2006

Article Tools