The Journal of Pediatrics
Volume 148, Issue 5 , Pages 573-574 , May 2006

Expanding applications for metformin in polycystic ovarian syndrome

  • James H. Liu, MD

      Affiliations

    • Department of Reproductive Biology, Case School of Medicine, Cleveland, Ohio
    • Corresponding Author InformationReprint requests: Dr. James Liu, University Hospital, Obstetrics and Gynecology, 11100 Euclid Avenue, MAC7105, Cleveland, OH 44106-5034.
    • ,
  • Arthur H. Bill, Prof.

      Affiliations

    • Department of Obstetrics and Gynecology, University MacDonald Women’s Hospital, Cleveland, Ohio

References 

  1. Franks S . Polycystic ovarian syndrome . N Engl J Med . 1995;333:853–861
  2. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) . Hum Reprod . 2004;19:41–47
  3. Ehrman D . Polycystic ovary syndrome . N Engl J Med . 2005;352:1223–1236
  4. Ehrmann D , Sturis J , Byrne MM , Karrison T , Rosenfield RL , Polonsky KS . Insulin secretory defects in polycystic ovary syndrome (relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus) . J Clin Invest . 1995;96:520–527
  5. Velazquez EM , Menodoza S , Hamer T , Sosa F , Glueck CJ . Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy . Metabolism . 1994;43:647–654
  6. Nestler JE , Jakubowicz DJ , Evans WS , Pasquali R . Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome . N Engl J Med . 1998;338:1876–1880
  7. Lord JM , Flight IHK , Norman RJ . Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome . Cochrane Database Syst Rev . 2003;3: CD003053
  8. Jakubowicz DJ , Iuorno MJ , Jakubowicz S , Roberts KA , Nestler JE . Effects of metformin on early pregnancy loss in the polycystic ovary syndrome . J Clin Endocrinol Metab . 2002;87:524–529
  9. Glueck CJ , Wang P , Goldenberg N , Sieve-Smith L . Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin . Hum Reprod . 2002;17:2858–2864
  10. Coetzee EJ , Jackson WP . Oral hypoglycaemics in the first trimester and fetal outcome . S Afr Med J . 1984;65:635–637
  11. Glueck CJ , Wang P , Kobayashi S , Phillips H , Sieve-Smith L . Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome . Fertil Steril . 2002;77:520–525
  12. Vanky E , Salvesen KA , Heimstad R , Fougner KJ , Romundstad P , Carlsen SM . Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women (results of a randomized study) . Hum Reprod . 2004;19:1734–1740
  13. Glueck CJ , Goldenberg N , Pranikoff J , Loftspring M , Sieve L , Wang P . Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy . Hum Reprod . 2004;19:1323–1330
  14. Glueck CJ , Salehi M , Sieve L , Wang P . Growth, motor, and social development in breast and formula fed infants of metformin treated women with polycystic ovary syndrome . J Pediatr . 2006;148:628–632
  15. Briggs GG , Ambrose PJ , Nageotte MP , Padilla G , Wan S . Excretion of metformin into breast milk and the effect on nursing infants . Obstet Gynecol . 2005;105:1437–1441

PII: S0022-3476(06)00200-9

doi: 10.1016/j.jpeds.2006.03.016

The Journal of Pediatrics
Volume 148, Issue 5 , Pages 573-574 , May 2006

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