The Journal of Pediatrics
Volume 148, Issue 5 , Pages 571-573 , May 2006

Targeting B cells in the treatment of childhood-onset systemic lupus erythematosus

  • Jennifer L. Huggins, MD (Clinical Fellow)
    • ,
  • Hermine I. Brunner, MD, MSc (Assistant Professor)

      Affiliations

    • Corresponding Author InformationReprint requests: Dr Hermine I. Brunner, Assistant Professor, Division of Rheumatology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039

References 

  1. Lipsky PE . Systemic lupus erythematosus (an autoimmune disease of B cell hyperactivity) . Nat Immunol . 2001;2:764–766
  2. Chan OT , Madaio MP , Shlomchik MJ . The central and multiple roles of B cells in lupus pathogenesis . Immunol Rev . 1999;169:107–121
  3. Reff ME , Carner K , Chambers KS , et al.   Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20 . Blood . 1994;83:435–445
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  5. Shan D , Ledbetter JA , Press OW . Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells . Cancer Immunol Immunother . 2000;48:673–683
  6. Anolik JH , Campbell D , Felgar RE , et al.   The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus . Arthritis Rheum . 2003;48:455–459
  7. Sfikakis PP , Boletis JN , Tsokos GC . Rituximab anti-B-cell therapy in systemic lupus erythematosus (pointing to the future) . Curr Opin Rheumatol . 2005;17:550–557
  8. Leandro MJ , Edwards JC , Cambridge G , et al.   An open study of B lymphocyte depletion in systemic lupus erythematosus . Arthritis Rheum . 2002;46:2673–2677
  9. Looney RJ , Anolik JH , Campbell D , et al.   B cell depletion as a novel treatment for systemic lupus erythematosus (a phase I/II dose-escalation trial of rituximab) . Arthritis Rheum . 2004;50:2580–2589
  10. Sfikakis PP , Boletis JN , Lionaki S , et al.   Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand (an open-label trial) . Arthritis Rheum . 2005;52:501–513
  11. Marks SD , Patey S , Brogan PA , et al.   B lymphocyte depletion therapy in children with refractory systemic lupus erythematosus . Arthritis Rheum . 2005;52:3168–3174
  12. Willems M , Haddad E , Niaudet P , et al.   Rituximab therapy for childhood-onset systemic lupus erythematosus . J Pediatr . 2006; xxxx
  13. Janwityanujit S , Totemchokchyakarn K , Verasertniyom O , et al.   Age-related differences on clinical and immunological manifestations of SLE . Asian Pac J Allergy Immunol . 1995;13:145–149
  14. Arce E , Jackson DG , Gill MA , et al.   Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus . J Immunol . 2001;167:2361–2369
  15. Odendahl M , Keitzer R , Wahn U , et al.   Perturbations of peripheral B lymphocyte homoeostasis in children with systemic lupus erythematosus . Ann Rheum Dis . 2003;62:851–858
  16. Odendahl M , Jacobi A , Hansen A , et al.   Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus . J Immunol . 2000;165:5970–5979
  17. Jacobi AM , Odendahl M , Reiter K , et al.   Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus . Arthritis Rheum . 2003;48:1332–1342
  18. Dorner T , Lipsky PE . Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus . Lupus . 2004;13:283–289
  19. Klein U , Rajewsky K , Kuppers R . Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes (CD27 as a general marker for somatically mutated (memory) B cells) . J Exp Med . 1998;188:1679–1689
  20. Anolik JH , Barnard J , Cappione A , et al.   Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus . Arthritis Rheum . 2004;50:3580–3590

PII: S0022-3476(06)00164-8

doi: 10.1016/j.jpeds.2006.03.011

The Journal of Pediatrics
Volume 148, Issue 5 , Pages 571-573 , May 2006

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