The Journal of Pediatrics
Volume 148, Issue 6 , Pages 730-734.e1 , June 2006

Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: Further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP)

Received 24 July 2005 ,Revised 23 December 2005 ,Accepted 27 January 2006.

References 

  1. Schmidt B , Davis P , Moddemann D , Ohlsson A , Roberts RS , Saigal S , et al.   Long-term effects of indomethacin prophylaxis in extremely low birth weight infants . N Engl J Med . 2001;344:1966–1972
  2. Fowlie PW , Davis PG . Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants . Cochrane Database Syst Rev . 2002;CD000174
  3. Brown ER . Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosus . J Pediatr . 1979;95:865–866
  4. Rojas MA , Gonzalez A , Bancalari E , Claure N , Poole C , Silva-Neto G . Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease . J Pediatr . 1995;126:605–610
  5. Todd DA , Jana A , John E . Chronic oxygen dependency in infants born at 24–32 weeks’ gestation (the role of antenatal and neonatal factors) . J Paediatr Child Health . 1997;33:402–407
  6. Marshall DD , Kotelchuck M , Young TE , Bose CL , Kruyer L , O’Shea TM  North Carolina Neonatologists Association . Risk factors for chronic lung disease in the surfactant era (a North Carolina population-based study of very low birth weight infants) . Pediatrics . 1999;104:1345–1350
  7. Bancalari E . Changes in the pathogenesis and prevention of chronic lung disease of prematurity . Am J Perinatol . 2001;18:1–9
  8. Gournay V , Savagner C , Thiriez G , Kuster A , Roze J-C . Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants . Lancet . 2002;359:1486–1488
  9. Schmidt B , Wright LL , Davis P , Solimano A , Roberts RS  Indomethacin Prophylaxis in Preterms Investigators . Ibuprofen prophylaxis in preterm neonates . Lancet . 2002;360:492
  10. Lassus P , Viinikka L , Ylikorkala O , Pohjavuori M , Andersson S . Pulmonary prostacyclin is associated with less severe respiratory distress in preterm infants . Early Hum Dev . 2002;67:11–18
  11. Gerdes JS , Harris MC , Polin RA . Effects of dexamethasone and indomethacin on elastase, alpha 1-proteinase inhibitor, and fibronectin in bronchoalveolar lavage fluid from neonates . J Pediatr . 1988;113:727–731
  12. Yaseen H , al Umran K , Ali H , Rustum M , Darwich M , al-Faraidy A . Effects of early indomethacin administration on oxygenation and surfactant requirement in low birth weight infants . J Trop Pediatr . 1997;43:42–46
  13. Van Overmeire B , Van de Broek H , Van Laer P , Weyler J , Vanhaesebrouck P . Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome . J Pediatr . 2001;138:205–211
  14. McCurnin DC , Yoder BA , Coalson J , Grubb P , Kerecman J , Kupferschmid J , et al.   Effect of ductus ligation on cardiopulmonary function in premature baboons . Am J Respir Crit Care Med . 2005;172:1569–1574
  15. Laughon MM , Simmons MA , Bose CL . Patency of the ductus arteriosus in the premature infant. Is it pathologic? Should it be treated? . Curr Opin Pediatr . 2004;16:146–151

 Funded by the Medical Research Council of Canada (grant MT-13288). The US centers were supported in part by NICHD (grants U10 HD21364, U10 HD27851, U10 HD21373, U10 HD27881; M01 RR 00997, U10 HD27880; M01 RR 00070, U10 HD21385, U10 HD27904, and U10 HD34216). The INDOCID PDA was donated by Merck Frosst.

PII: S0022-3476(06)00074-6

doi: 10.1016/j.jpeds.2006.01.047

The Journal of Pediatrics
Volume 148, Issue 6 , Pages 730-734.e1 , June 2006

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