The Journal of Pediatrics
Volume 149, Issue 3 , Pages 308-313 , September 2006

Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable?

Presented at the Annual Meeting of the Pediatric Academic Societies, Washington, DC, May 16, 2005.

  • Jaideep Singh, MD

      Affiliations

    • From James Cook University Hospital, Middlesbrough, United Kingdom; Hope Hospital, Salford, United Kingdom; and the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, C.S. Mott Children’s Hospital, Ann Arbor, Michigan
    • ,
  • Sunil K. Sinha, MD, PhD

      Affiliations

    • From James Cook University Hospital, Middlesbrough, United Kingdom; Hope Hospital, Salford, United Kingdom; and the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, C.S. Mott Children’s Hospital, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests: Prof Sunil K. Sinha, Professor of Paediatrics & Neonatal Medicine, University of Durham & James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK.
    • ,
  • Paul Clarke, MB, FRCPCH

      Affiliations

    • From James Cook University Hospital, Middlesbrough, United Kingdom; Hope Hospital, Salford, United Kingdom; and the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, C.S. Mott Children’s Hospital, Ann Arbor, Michigan
    • ,
  • Steve Byrne, MD, PHD

      Affiliations

    • From James Cook University Hospital, Middlesbrough, United Kingdom; Hope Hospital, Salford, United Kingdom; and the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, C.S. Mott Children’s Hospital, Ann Arbor, Michigan
    • ,
  • Steven M. Donn, MD

      Affiliations

    • From James Cook University Hospital, Middlesbrough, United Kingdom; Hope Hospital, Salford, United Kingdom; and the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, C.S. Mott Children’s Hospital, Ann Arbor, Michigan

Received 18 August 2005 ,Revised 16 December 2005 ,Accepted 23 January 2006.

References 

  1. Attar MA , Donn SM . Mechanisms of ventilator-induced lung injury in premature infants . Semin Neonatol . 2002;7:353–360
  2. Dreyfuss D , Saumon G . Barotrauma is volutrauma, but which volume is the one responsible? . Intensive Care Med . 1992;18:139–141
  3. Clark RH , Slutsky AS , Gerstmann DR . Lung protective strategies of ventilation in the neonate (what are they?) . Pediatrics . 2000;105:112–114
  4. Clark RH , Gerstmann DR , Jobe AH , Moffitt ST , Slutsky AS , Yoder BA . Lung injury in neonates (causes, strategies for prevention, and long-term consequences) . J Pediatr . 2001;139:478–486
  5. Donn SM , Sinha SK . Newer modes of mechanical ventilation for the neonate . Curr Opin Pediatr . 2001;13:99–103
  6. Sinha S , Donn S . Volume-controlled ventilation (variations on a theme) . Clin Perinatol . 2001;28:547–560
  7. Sinha SK , Donn SM , Gavey J , McCarty M . Randomised trial of volume controlled versus time cycled, pressure limited ventilation in preterm infants with respiratory distress syndrome . Arch Dis Child Fetal Neonatal Ed . 1997;77:F202–F205
  8. Dreyfuss D , Saumon G . Ventilator-induced lung injury (lessons from experimental studies) . Am J Respir Crit Care Med . 1998;157:294–323
  9. Anonymous  . Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network . N Engl J Med . 2000;342:1301–1308
  10. Piotrowski A , Sobala W , Kawczynski P . Patient-initiated, pressure-regulated, volume-controlled ventilation compared with intermittent mandatory ventilation in neonates (a prospective, randomised study) . Intensive Care Med . 1997;23:975–981
  11. Lista G , Colnaghi M , Castoldi F , Condo V , Reali R , Compagnoni G , et al.   Impact of targeted-volume ventilation on lung inflammatory responce in preterm infants with respiratory distress syndrome (RDS) . Pediatr Pulmonol . 2004;37:510–514
  12. Keszler M , Abubakar K . Volume guarantee (stability of tidal volume and incidence of hypocarbia) . Pediatr Pulmonol . 2004;38:240–245
  13. McCallion N , Davis P , Morley C . Volume-targeted versus pressure-limited ventilation in the neonate . [review] The Cochrane Database of Systematic Reviews . 2005; , issue 3

PII: S0022-3476(06)00071-0

doi: 10.1016/j.jpeds.2006.01.044

The Journal of Pediatrics
Volume 149, Issue 3 , Pages 308-313 , September 2006

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