The Journal of Pediatrics
Volume 148, Issue 5 , Pages 623-627.e3 , May 2006

Rituximab therapy for childhood-onset systemic lupus erythematosus

  • M. Willems, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • E. Haddad, MD, PhD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • P. Niaudet, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • I. Koné-Paut, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • A. Bensman, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • P. Cochat, MD, PhD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • G. Deschênes, MD, PhD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • F. Fakhouri, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • T. Leblanc, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • B. Llanas, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • C. Loirat, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • P. Pillet, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • B. Ranchin, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • R. Salomon, MD, PhD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • T. Ulinski, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • ,
  • Brigitte Bader-Meunier, MD

      Affiliations

    • Department of Pediatrics, Hôpital de Bicêtre, Le Kremlin Bicêtre, France
    • Immuno-Allergy and Rheumatology Unit, CHU Sainte-Justine, Mother and Child University Hospital Center, Universite de Montreal, Montreal, Quebec, Canada
    • Department of Pediatric Nephrology, Hôpital Necker, Paris, France; Department of Pediatric Nephrology, Hôpital Trousseau, Paris, France
    • Department of Pediatric Nephrology, Hôpital Edouard-Herriot, Lyon, France; Department of Nephrology, Hôpital Necker, Paris, France
    • Department of Pediatric Hematology, Hôpital Saint Louis, Paris, France
    • Department of Pediatrics, Hôpital Pellegrin, Bordeaux, France
    • Department of Pediatric Nephrology, Hôpital R. Debré, Paris, France
    • Corresponding Author InformationReprint requests: Brigitte Bader-Meunier, Service de Pédiatrie générale, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94276 Le Kremlin Bicêtre, France
    • ,
  • French pediatric-onset SLE study group

      Affiliations

    • Complete list of participating centers is available at www.jpeds.com

Received 18 July 2005 ,Revised 12 December 2005 ,Accepted 20 January 2006.

References 

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  17. Weening JJ , D’Agati VD , Schwartz MM , Seshan SV , Alpers CE , Appel GB , et al.   The classification of glomerulonephritis in systemic lupus erythematosus revisited . J Am Soc Nephrol . 2004;15:241–250
  18. Zecca M , Nobili B , Ramenghi U , Perrotta S , Amendola G , Rosito P , et al.   Rituximab for the treatment of refractory autoimmune hemolytic anemia in children . Blood . 2003;101:3857–3861
  19. Quartier P , Brethon B , Phillippet P , Landman-Parker J , Le Deist F , Fischer A . Treatment of childhood autoimmune haemolytic anemia with rituximab . Lancet . 2001;358:1511–1513
  20. Wang J , Wiley JM , Luddy R , Greenberg J , Feuerstein MA , Bussel JB . Chronic immune thrombocytopenic purpura in children (assessment of rituximab treatment) . J Pediatr . 2005;146:217–221
  21. Wylam ME , Peter M , Anderson PM , Kuntz NL , Rodriguez V . Successful treatment of refractory myasthenia gravis using rituximab (a pediatric case report) . J Pediatr . 2003;143:674–677
  22. Binstadt BA , Caldas A , Turvey S , Weinstein HJ , Jackson J Fulhbrigge RC , et al.   Rituximab therapy for multisystem autoimmune diseases in pediatric patient . J Pediatr . 2003;143:598–604
  23. Perotta S , Locatelli F , La Manna A , Cennamo L , De Stefano P , Nobili B . Anti-CD20 monoclonal antibody (rituximab) for life-threatening autoimmune haemolytic anaemia in a patient with systemic lupus erythematosus . Br J Hematol . 2002;116:465–467
  24. Cate R , Smiers FJ , Bredius RGM , Lankester AC , Van Suijlekom-Smit LWA , Huizinga TW , et al.   Anti-CD20 monoclonal antibody (rituximab) for refractory autoimmune thrombocytopenia in a girl with systemic lupus erythematosus . Rheumatology . 2004;43:244
  25. Marks SD , Patey S , Brogan PA , Hasson N , Pilkington C , Woo P , et al.   B lymphocyte depletion therapy in children with refractory systemic lupus erythematosus . Arthritis Rheum . 2005;52:3168–3174
  26. Edelbauer M , Jungraithmayr T , Zimmerhackl LB . Rituximab in childhood systemic lupus erythematosus refractory to conventional immunosuppression . Pediatr Nephrol . 2005;20:811–813
  27. Kneitz C , Wilhelm M , Tony HP . Effective B cell depletion with Rituximab in the treatment of autoimmune diseases . Immunobiology . 2002;206:519–527
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  29. Van Vollenhoven RF , Gunnarson I , Welin-Henriksson E , Sundelin B , Osenberg A , Jacobson SHJ , et al.   Biopsy-verified response of severe lupus nephritis to treatment with rituximab (anti-CD20 monoclonal antibody) plus cyclophosphamide after biopsy documented failure to respons to cyclophosphamide alone . Scand J Rheumatol . 2004;33:423–427
  30. Ahn ER , Lander G , Bidot CJ , Jy W , Ahn YS . Long-term remission from life-threatening hypercoagulable state associated with lupus anticoagulant (LA) following rituximab therapy . Am J Hematol . 2005;78:127–129
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 Supported by a grant from the Association française pour le syndrome d’Evans.

PII: S0022-3476(06)00069-2

doi: 10.1016/j.jpeds.2006.01.041

The Journal of Pediatrics
Volume 148, Issue 5 , Pages 623-627.e3 , May 2006

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