The Journal of Pediatrics
Volume 148, Issue 2 , Pages 188-194 , February 2006

Waist circumference is an independent predictor of insulin resistance in black and white youths

  • SoJung Lee, PhD
  • ,
  • Fida Bacha, MD
  • ,
  • Neslihan Gungor, MD
  • ,
  • Silva A. Arslanian, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Silva A. Arslanian, MD, Children’s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213

Received 19 May 2005 ,Revised 30 August 2005 ,Accepted 3 October 2005.

References 

  1. Rexrode KM , Carey VJ , Hennekens CH , Walters EE , Colditz GA , Stampfer MJ , et al.   Abdominal adiposity and coronary heart disease in women . JAMA . 1998;280:1843–1848
  2. Ohlson LO , Larsson B , Svardsudd K , Welin L , Eriksson H , Wilhelmsen L , et al.   The influence of body fat distribution on the incidence of diabetes mellitus (13.5 years of follow-up of the participants in the study of men born in 1913) . Diabetes . 1985;34:1055–1058
  3. Zhu S , Heshka S , Wang Z , Shen W , Allison DB , Ross R , et al.   Combination of BMI and waist circumference for identifying cardiovascular risk factors in whites . Obes Res . 2004;12:633–645
  4. Ardern CI , Katzmarzyk PT , Janssen I , Ross R . Discrimination of health risk by combined body mass index and waist circumference . Obes Res . 2003;11:135–142
  5. Janssen I , Katzmarzyk PT , Ross R . Body mass index, waist circumference, and health risk (evidence in support of current National Institutes of Health guidelines) . Arch Intern Med . 2002;162:2074–2079
  6. Janssen I , Katzmarzyk PT , Ross R . Waist circumference and not body mass index explains obesity-related health risk . Am J Clin Nutr . 2004;79:379–384
  7. Janssen I , Heymsfield SB , Allison DB , Kotler DP , Ross R . Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous, and visceral fat . Am J Clin Nutr . 2002;75:683–688
  8. Cole TJ , Bellizzi MC , Flegal KM , Dietz WH . Establishing a standard definition for child overweight and obesity worldwide (international survey) . BMJ . 2000;320:1240–1243
  9. Daniels SR , Khoury PR , Morrison JA . The utility of body mass index as a measure of body fatness in children and adolescents (differences by race and gender) . Pediatrics . 1997;99:804–807
  10. Maynard LM , Wisemandle W , Roche AF , Chumlea WC , Guo SS , Siervogel RM . Childhood body composition in relation to body mass index . Pediatrics . 2001;107:344–350
  11. Moreno LA , Pineda I , Rodriguez G , Fleta J , Sarria A , Bueno M . Waist circumference for the screening of the metabolic syndrome in children . Acta Paediatr . 2002;91:1307–1312
  12. Maffeis C , Corciulo N , Livieri C , Rabbone I , Trifiro G , Falorni A , et al.   Waist circumference as a predictor of cardiovascular and metabolic risk factors in obese girls . Eur J Clin Nutr . 2003;57:566–572
  13. McCarthy HD , Ellis SM , Cole TJ . Central overweight and obesity in British youth aged 11-16 years (cross sectional surveys of waist circumference) . BMJ . 2003;326:624
  14. Bjorntorp P . ’Portal’ adipose tissue as a generator of risk factors for cardiovascular disease and diabetes . Arteriosclerosis . 1990;10:493–496
  15. Katzmarzyk PT , Srinivasan SR , Chen W , Malina RM , Bouchard C , Berenson GS . Body mass index, waist circumference, and clustering of cardiovascular disease risk factors in a biracial sample of children and adolescents . Pediatrics . 2004;114:e198–e205
  16. Freedman DS , Khan LK , Dietz WH , Srinivasan SR , Berenson GS . Relationship of childhood obesity to coronary heart disease risk factors in adulthood (the Bogalusa Heart Study) . Pediatrics . 2001;108:712–718
  17. Freedman DS , Khan LK , Serdula MK , Dietz WH , Srinivasan SR , Berenson GS . The relation of childhood BMI to adult adiposity (the Bogalusa Heart Study) . Pediatrics . 2005;115:22–27
  18. Arslanian SA , Saad R , Lewy V , Danadian K , Janosky J . Hyperinsulinemia in black children (decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity) . Diabetes . 2002;51:3014–3019
  19. Bacha F , Saad R , Gungor N , Janosky J , Arslanian SA . Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents (race differential in diabetogenic and atherogenic risk factors) . J Clin Endocrinol Metab . 2003;88:2534–2540
  20. Kuczmarski RJ , Ogden CL , Guo SS , Grummer-Strawn LM , Flegal KM , Mei Z , et al.   2000 CDC Growth Charts for the United States (methods and development) . Vital Health Stat . 2002;11:1–190
  21. Danadian K , Balasekaran G , Lewy V , Meza MP , Robertson R , Arslanian SA . Insulin sensitivity in black children with and without family history of type 2 diabetes . Diabetes Care . 1999;22:1325–1329
  22. Arslanian SA , Lewy VD , Danadian K . Glucose intolerance in obese adolescents with polycystic ovary syndrome (roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease) . J Clin Endocrinol Metab . 2001;86:66–71
  23. Lewy VD , Danadian K , Witchel SF , Arslanian S . Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome . J Pediatr . 2001;138:38–44
  24. Fernandez JR , Redden DT , Pietrobelli A , Allison DB . Waist circumference percentiles in nationally representative samples of black, European-American, and Mexican-American children and adolescents . J Pediatr . 2004;145:439–444
  25. Barlow SE , Dietz WH . Obesity evaluation and treatment: Expert Committee recommendations: the Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Services . Pediatrics . 1998;102:E29
  26. Bigaard J , Tjonneland A , Thomsen BL , Overvad K , Heitmann BL , Sorensen TI . Waist circumference, BMI, smoking, and mortality in middle-aged men and women . Obes Res . 2003;11:895–903
  27. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report: National Institutes of Health . Obes Res . 1998;6(Suppl 2):51S–209S
  28. Goran MI , Kaskoun M , Shuman WP . Intra-abdominal adipose tissue in young children . Int J Obes Relat Metab Disord . 1995;19:279–283
  29. Weiss R , Dufour S , Taksali SE , Tamborlane WV , Petersen KF , Bonadonna RC , et al.   Prediabetes in obese youth (a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning) . Lancet . 2003;362:951–957
  30. Savva SC , Tornaritis M , Savva ME , Kourides Y , Panagi A , Silikiotou N , et al.   Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass index . Int J Obes Relat Metab Disord . 2000;24:1453–1458
  31. Freedman DS , Serdula MK , Srinivasan SR , Berenson GS . Relation of circumferences and skinfold thicknesses to lipid and insulin concentrations in children and adolescents (the Bogalusa Heart Study) . Am J Clin Nutr . 1999;69:308–317
  32. Katzmarzyk PT . Waist circumference percentiles for Canadian youth 11-18 y of age . Eur J Clin Nutr . 2004;58:1011–1015
  33. McCarthy HD , Jarrett KV , Crawley HF . The development of waist circumference percentiles in British children aged 5.0-16.9 y . Eur J Clin Nutr . 2001;55:902–907

 This research was supported by US Public Health Service Grants RO1-HD-27503, K24-HD-01357, and MO1-RR-00084 and the GCRC and Eli Lilly and Company.

PII: S0022-3476(05)00982-0

doi: 10.1016/j.jpeds.2005.10.001

The Journal of Pediatrics
Volume 148, Issue 2 , Pages 188-194 , February 2006