The Journal of Pediatrics
Volume 148, Issue 1 , Pages 5-6 , January 2006

The Role of Genetic Susceptibility for Maternal Alcohol Metabolism in Determining Pregnancy Outcome

  • Kenneth Lyons Jones, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Kenneth Lyons Jones, MD, Department of Pediatrics, Division of Dysmorphology/Teratology MC 8446, University of California San Diego, School of Medicine, La Jolla CA 92093.

References 

  1. Buehler BA, Delimont D, Van Waes M, Finnell RH. Prenatal prediction of risk of the fetal hydantoin syndrome. N Engl J Med. 1990;322:1567–1572
  2. Shaw GM, Wasserman CR, Lammer EJ, O'Malley CD, Murray JC, Basart AM, et al. Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants. Am J Hum Genet. 1996;58:551–561
  3. Warren KR, Li K-T. Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders. Birth Defects Res A Clin Mol Teratol. 2005;73:195–203
  4. Jacobson SW, Carr LG, Croxford J, Sokol RJ, Li T-K, Jacobson JL. Protective effects of the alcohol dehydrogenase-ADH1B allele in African American children exposed to alcohol during pregnancy. J Pediatr. 2006;148:30–37
  5. Thomasson HR, Beard JD, Li T-K. ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol Clin Exp Res. 1995;19:1494–1499
  6. Abel EL. An update on incidence of FAS: FAS is not an equal opportunity birth defect. Neurotoxicol Teratol. 1995;17:445–462
  7. Neumark YD, Friedlander Y, Durst R, Leitersdorf E, Jaffe D, Ramchandani VA, et al. Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. Alcohol Clin Exp Res. 2004;28:10–14
  8. McCarver DF, Thomasson HR, Martier SS, Sokol RJ, Li T-K. Alcohol dehydrogenase-2∗3 allele protects against alcohol-related birth defects among African Americans. JPET. 1997;283:1095–1101
  9. Stoler JM, Ryan LM, Holmes LB. Alcohol dehydrogenase 2 genotypes, maternal alcohol use, and infant outcome. J Pediatr. 2002;141:780–785

PII: S0022-3476(05)00905-4

doi: 10.1016/j.jpeds.2005.09.023

The Journal of Pediatrics
Volume 148, Issue 1 , Pages 5-6 , January 2006

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