The Journal of Pediatrics
Volume 147, Issue 1 , Pages 4-6 , July 2005

The Evidence Mounts Against Use of Pure Oxygen in Newborn Resuscitation

  • Nigel Paneth, MD, MPH

      Affiliations

    • Corresponding Author InformationReprint requests: Nigel Paneth, MD, MPH, B636 West Fee Hall, East Lansing, MI 48824.

References 

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  4. National Children's Study Workshop. Cancer and the National Children's Study; Opportunities and Challanges; May 20, 2004. Available from http://www.nationalchildrensstudy.gov/events/workshops/Cancer05202004.cfm.
  5. Naumburg E, Bellocco R, Cnattingius S, Jonzon A, Ekbom A. Supplementary oxygen and risk of childhood lymphatic leukaemia. Acta Paediatr. 2002;91:1328–1333
  6. Vento M, Asensi M, Sastre J, Garcia-Sala F, Pallardo FV, Vina J. Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics. 2001;107:642–647
  7. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 2004;266:37–56
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  11. Tin W, Milligan DW, Pennefather P, Hey E. Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. Arch Dis Child Fetal Neonatal Ed. 2001;84:106–110
  12. The STOP-ROP Multicenter Study Group . Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: Primary outcomes. Pediatrics. 2000;105:295–310
  13. Collins M, Paneth N, Lorenz J. Hypocapnia, prolonged ventilation, and risk of disabling cerebral palsy in low birth weight infants. Pediatr Res. 2001;50:712–719
  14. Davis PG, Tan A, O'Donnell CP, Schulze A. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet. 2004;364:1329–1333
  15. Saugstad OD, Ramji S, Vento M. Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis. Biol Neonate. 2005;87:27–34
  16. Saugstad OD, Ramji S, Irani SF, El-Meneza S, Hernandez EA, Vento M, et al. Resuscitation of newborn infants with 21% or 100% oxygen: follow-up at 18 to 24 months. Pediatrics. 2003;112:296–300

 This commentary benefited from the helpful advice of Drs. John L. Lorenz and Jon Tyson, who are not, however, responsible for its conclusions.

PII: S0022-3476(05)00393-8

doi: 10.1016/j.jpeds.2005.04.058

The Journal of Pediatrics
Volume 147, Issue 1 , Pages 4-6 , July 2005

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