The Journal of Pediatrics
Volume 146, Issue 4 , Pages 565-567, April 2005

Dizygotic twin pregnancy conceived with assisted reproductive technology associated with chromosomal anomaly, imprinting disorder, and monochorionic placentation

From the Department of Pediatrics, Division of Medical Genetics, University of California San Francisco; the Department of Pediatrics, University of California San Diego; and the Department of Medical Genetics, Shodair Children's Hospital, Helena, Montana

Received 12 August 2004; received in revised form 5 November 2004; accepted 9 December 2004.

See editorial, p 450.

Assisted reproductive technology (ART) has now become a cornerstone of treatment for involuntary infertility. Recent studies have raised concern regarding potential associations between ART and chromosomal aneuploidy, imprinting anomalies, and monochorionic placentation in dizygotic (DZ) twins. We report a case of DZ twins conceived by ART in which all three problems coexist.

ART, Assisted reproductive technology, BWS, Beckwith-Wiedemann syndrome, DZ, Dizygotic, ICSI, Intra-cytoplasmic sperm injection, IVF, In vitro fertilization, MZ, Monozygotic

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PII: S0022-3476(04)01173-4

doi:10.1016/j.jpeds.2004.12.021

The Journal of Pediatrics
Volume 146, Issue 4 , Pages 565-567, April 2005