The Journal of Pediatrics
Volume 145, Issue 5 , Pages 581-583 , November 2004

An approach to target joint bleeding in hemophilia: Prophylaxis for all or individualized treatment?

  • Thomas Abshire, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Dr Thomas Abshire, Director, Comprehensive Hemophilia Program, AFLAC Cancer Center and Blood Disorders Service, 2015 Uppergate Drive, Emory University, Atlanta, GA 30322.

References 

  1. Kern M, Blanchette V, Stain AM, Einarson TR, Feldman BM. Clinical and cost implications of target joints in Canadian boys with severe hemophilia A. J Pediatr. 2004;145:628–634
  2. Aledort LM, Haschemeyer R, Pettersson H, Group TOOS . A longitudinal study of orthopaedic outcomes for serve factor-VIII-deficient haemophiliacs. J Int Medicine. 1994;236:391–399
  3. Hirschman RJ, Itscoitz SB, Shulman NR. Prophylactic treatment of factor VIII deficiency. Blood. 1970;35:189–194
  4. Aronstam A, Arblaster PG, Rainsford SG, Turk P, Slattery M, Alderson MR, et al. Prophylaxis in haemophilia: a double-blind controlled trial. Br J Haematol. 1976;33:81–90
  5. Fischer K, van der Bom JG, Mauser-Bunschoten EP, Roosendaal G, Prejs R, de kleijn P, et al. The effects of postponing prophylactic treatment on long-term outcome in patients with severe hemophilia. Blood. 2002;99:2337–2341
  6. Nilsson IM, Berntorp E, Lofqvist T, Pettersson H. Twenty-five years' experience of prophylactic treatment in severe haemophilia A. B. J Intern Med. 1992;232:25–32
  7. Blanchette VS, Rivard GE, Israels SJ, Robinson KS, Babyn PS, McLimont MJ, et al. Musculoskeletal results from the Canadian hemophilia dose-escalation prophylaxis trial. Blood. 2003;102:52a
  8. Astermark J, Petrini P, Tengborn L, Schulman S, Ljung R, Berntorp E. Primary prophylaxis in severe haemophilia should be started at an early age but can be individualized. Br J Haematol. 1999;105:1109–1113
  9. Blanchette VS, McCready M, Achonu C, Abdolell M, Rivard G, Manco-Johnson MJ. A survey of factor prophylaxis in boys with haemophilia followed in North American haemophilia treatment centres. Haemophilia. 2003;9(suppl 1):19–26
  10. Price VE, Carcao M, Connolly B, Chait P, Daneman A, Temple M, et al. A prospective, longitudinal study of central venous catheter-related deep venous thrombosis in boys with hemophilia. J Thromb Haemost. 2004;2:737–742
  11. Dunn AL, Busch MT, Wyly JB, Sullivan KM, Abshire TC. Arthroscopic synovectomy for hemophilic joint disease in a pediatric population. J Pediatr Orthop. 2004;24:414–426

PII: S0022-3476(04)00759-0

doi: 10.1016/j.jpeds.2004.08.040

The Journal of Pediatrics
Volume 145, Issue 5 , Pages 581-583 , November 2004

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