The Journal of Pediatrics
Volume 145, Issue 5 , Pages 646-651 , November 2004

Expanding the phenotype of alveolar capillary dysplasia (ACD)

Received 19 February 2004 ,Revised 18 May 2004 ,Accepted 29 June 2004.

References 

  1. Gersony WM. Neonatal pulmonary hypertension: pathophysiology, classification, and etiology. Clin Perinatol. 1984;11:517–524
  2. Stoll BJ, Kliegman RM. Persistent pulmonary hypertension of the newborn (PPHN). In:  Behrman RE,  Kliegman RM,  Jenson HB editor. Nelson textbook of pediatrics. Philadelphia (PA): WB Saunders; 2000;p. 506–508
  3. MacMahon HE. Congenital alveolar dysplasia. Am J Pathol. 1948;24:919–930
  4. Janney CG, Askin FB, Kuhn C. Congenital alveolar capillary dysplasia: an unusual cause of respiratory distress in the newborn. Am J Clin Pathol. 1981;76:722–727
  5. Wagenvoort CA. Misalignment of lung vessels: a syndrome causing persistent neonatal pulmonary hypertension. Hum Pathol. 1986;17:727–730
  6. Langston C. Misalignment of pulmonary veins and alveolar capillary dysplasia. Pediatr Pathol. 1991;11:163–170
  7. Abdallah HI, Karmazin N, Marks LA. Late presentation of misalignment of lung vessels with alveolar capillary dysplasia. Crit Care Med. 1993;21:628–630
  8. Boggs S, Harris MC, Hoffman DJ, Goel R, McDonald-McGinn D, Langston C, et al. Misalignment of pulmonary veins with alveolar capillary dysplasia: affected siblings and variable phenotypic expression. J Pediatr. 1994;124:125–128
  9. Gutierrez C, Rodriguez A, Palenzuela S, Forteza C, Rossello JL. Congenital misalignment of pulmonary veins with alveolar capillary dysplasia causing persistent neonatal pulmonary hypertension: report of two affected siblings. Pediatr Dev Pathol. 2000;3:271–276
  10. Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, et al. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet. 2000;67:737–744
  11. Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA, Loyd JE, et al. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat Genet. 2000;26:81–84
  12. Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, Wheeler L, et al. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am J Hum Genet. 2001;68:92–102
  13. Rubin LJ. Primary pulmonary hypertension. N Engl J Med. 1997;336:111–117
  14. Schwarz MA, Zhang F, Gebb S, Starnes V, Warburton D. Endothelial monocyte activating polypeptide II inhibits lung neovascularization and airway epithelial morphogenesis. Mech Dev. 2000;95:123–132
  15. Burrow CR. Regulatory molecules in kidney development. Pediatr Nephrol. 2000;14:240–253
  16. Cardoso WV. Lung morphogenesis revisited: old facts, current ideas. Dev Dyn. 2000;219:121–130
  17. Roberts DJ. Molecular mechanisms of development of the gastrointestinal tract. Dev Dyn. 2000;219:109–120

 Supported in part by a grant from the National Institute of Child Health and Human Development (R03 HD044032-01).A full list of author acknowledgements can be found online at www.us.elsevierhealth.com/jpeds.

PII: S0022-3476(04)00647-X

doi: 10.1016/j.jpeds.2004.06.081

The Journal of Pediatrics
Volume 145, Issue 5 , Pages 646-651 , November 2004