The Journal of Pediatrics
Volume 143, Issue 6 , Pages 772-775 , December 2003

Relation between pancreatic lipase activity and gastric emptying rate in children with cystic fibrosis

Received 20 March 2003 ,Revised 28 July 2003 ,Accepted 29 August 2003.

References 

  1. Nousia-Arvanitakis S. Cystic fibrosis and the pancreas: recent scientific advances. J Clin Gastroenterol. 1999;29:138–142
  2. Wilschanski M, Rivlin J, Cohen S, Augarten A, Blau H, Aviram M, et al.  Clinical and genetic risk factors for cystic fibrosis-related liver disease. Pediatrics. 1999;103:52–57
  3. De Boeck K, Delbeke I, Eggermont E, Veereman-Wauters G, Ghoos Y. Lipid digestion in cystic fibrosis: comparison of conventional and high-lipase enzyme therapy using the mixed-triglyceride breath test. J Pediatr Gastroenterol Nutr. 1998;26:408–411
  4. Bronstein M, Sokol R, Abman S, Chatfield B, Hammond K, Hambidge K, et al.  Pancreatic insufficiency, growth, and nutrition in infants identified by newborn screening as having cystic fibrosis. J Pediatr. 1992;120:533–540
  5. Bruno M, Haverkort E, Tytgat G, van Leeuwen D. Maldigestion associated with exocrine pancreatic insufficiency: implications of gastrointestinal physiology and properties of enzyme preparations for a cause-related and patient-tailored treatment. Am J Gastroenterol. 1995;90:1383–1393
  6. Meyer J, Hlinka M, Kao D, Lake R, MacLaughlin E, Graham L, et al.  Gastric emptying of oil from solid and liquid meals. Dig Dis Sci. 1996;41:1691–1699
  7. Borowitz D, Baker R, Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2002;35:246–259
  8. Cavell B. Gastric emptying in infants with cystic fibrosis. Acta Paediatr Scand. 1981;70:635–638
  9. Collins C, Francis J, Thomas P, Henry R, O'Loughlin E. Gastric emptying time is faster in cystic fibrosis. J Pediatr Gastroenterol Nutr. 1997;25:492–498
  10. Cucchiara S, Raia V, Minella R, Frezza T, De Vizia B, De Ritis G. Ultrasound measurement of gastric emptying time in patients with cystic fibrosis and effect of ranitidine on delayed gastric emptying. J Pediatr. 1996;128:485–488
  11. Hyman P. Absent postprandial duodenal motility in a child with cystic fibrosis: correction of the symptoms and manometric abnormality with cisapride. Gastroenterology. 1986;90:1274–1279
  12. Roulet M, Weber A, Paradis Y, Roy C, Chartrand L, Lasalle R, et al.  Gastric emptying and lingual lipase activity in cystic fibrosis. Pediatr Res. 1980;14:1360–1362
  13. Smith H, Hollins G, Booth I, Weller P. Gastric emptying of liquids in cystic fibrosis. Acta Univ Carol [Med] (Praha). 1990;36:161–164
  14. Feinle C, Kunz P, Boesiger P, Fried M, Schwizer W. Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans. Gut. 1999;44:106–111
  15. Amarri S, Coward W, Harding M, Weaver L. Importance of measuring CO2-production rate when using 13C-breath tests to measure fat digestion. Br J Nutr. 1998;79:541–545
  16. Haycock G, Schwartz G, Wisotsky D. Geometric method for measuring body surface area: a height-weight formula validated in infants, children and adults. J Pediatr. 1978;93:62–66
  17. Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, et al.  Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology. 1993;104:1640–1647
  18. Maes B, Ghoos Y, Geypens B, Mys G, Hiele M, Rutgeerts P, et al.  Combined carbon-13-glycine/carbon-14-octanoic acid breath test to monitor gastric emptying rates of liquids and solids. J Nucl Med. 1994;35:824–831
  19. Kalivianakis M, Elstrodt J, Havinga R, Kuipers F, Stellaard F, Sauer P, et al.  Validation in an animal model of the carbon 13-labeled mixed triglyceride breath test for the detection of intestinal fat malabsorption. J Pediatr. 1999;135:444–450
  20. Vantrappen G, Rutgeerts P, Ghoos Y, Hiele M. Mixed triglyceride breath test: a noninvasive test of pancreatic lipase activity in the duodenum. Gastroenterology. 1989;96:1126–1134
  21. van Dijk-van Aalst K, van den Driessche M, van der Schoor S, Schiffelers S, van't Westeinde T, Ghoos Y, et al.  13C mixed triglyceride breath test: a noninvasive method to assess lipase activity in children. J Pediatr. 2001;32:579–585
  22. Choi M, Camilleri M, Burton D, Zinsmeister A, Forstrom L, Nair KS. [13C]Octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology. 1997;112:1155–1162
  23. Ghaneh P, Neoptolemos J. Pancreatic exocrine insufficiency following pancreatic resection. Digestion. 1999;60:104–110
  24. Anthony H, Collins C, Davidson G, Mews C, Robinson P, Shepherd R, et al.  Pancreatic enzyme replacement therapy in cystic fibrosis: Australian guidelines. J Paediatr Child Health. 1999;35:125–129
  25. Taylor C, Hillel P, Ghosal S, Frier M, Senior S, Tindale W, et al.  Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis. Arch Dis Child. 1999;80:149–152

PII: S0022-3476(03)00581-X

doi: 10.1067/S0022-3476(03)00581-X

The Journal of Pediatrics
Volume 143, Issue 6 , Pages 772-775 , December 2003