The Journal of Pediatrics
Volume 143, Issue 6 , Pages 789-795 , December 2003

Effects of iron therapy on infant blood lead levels

Received 9 December 2002 ,Revised 31 July 2003 ,Accepted 22 August 2003.

References 

  1. Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics. 2001;107:1381–1386
  2. CDC . Blood lead levels in young children—US and selected states, 1996-1999. MMWR Morb Mortal Wkly Rep. 2000;49:1133–1137
  3. Stoltzfus RJ. Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs. J Nutr. 2001;131:697S–700S
  4. Wasserman GA, Liu X, Popovac D, Factor-Litvak P, Kline J, Waternaux C, et al.  The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence. Neurotoxicol Teratol. 2000;22:811–818
  5. Yip R, Norris TN, Anderson AS. Iron status of children with elevated blood lead concentrations. J Pediatr. 1981;98:922–925
  6. Clark M, Royal J, Seeler R. Interaction of iron deficiency and lead and the hematologic findings in children with severe lead poisoning. Pediatrics. 1988;81:247–254
  7. Wright RO, Shannon MW, Wright RJ, Hu H. Association between iron deficiency and low-level lead poisoning in an urban primary care clinic. Am J Public Health. 1999;89:1049–1053
  8. Hammad TA, Sexton M, Langenberg P. Relationship between blood lead and dietary iron intake in preschool children: a cross-sectional study. Ann Epidemiol. 1996;6:30–33
  9. Lanphear B, Hornung R, Ho M, Howard C, Eberly S, Knauf K. Environmental lead exposure during early childhood. J Pediatr. 2002;140:40–47
  10. Angle CR, Stelmak KL, McIntire MS. Lead and iron deficiencies. In:  Hemphill DD editors. Trace substances in environmental health. Vol IX. Columbia (MO): University of Missouri; 1975;p. 367–386
  11. Ruff HA, Markowitz ME, Bijur PE, Rosen JF. Relationships among blood lead levels, iron deficiency, and cognitive development in two-year-old children. Environ Health Perspect. 1996;104:180–185
  12. Wright RO, Hu H, Maher TJ, Amarasiriwardena C, Chaiyakul P, Woolf AD, et al.  Effect of iron deficiency anemia on lead distribution after intravenous dosing in rats. Toxicol Ind Health. 1998;14:547–551
  13. Lozoff B, Brittenham GM, Wolf AW, McClish DK, Kuhnert PM, Jimenez E, et al.  Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics. 1987;79:981–995
  14. Wolf AW, Jimenez E, Lozoff B. No evidence of developmental III effects of low-level lead exposure in a developing country. J Dev Behav Pediatr. 1994;15:224–231
  15. Fernandez FJ. Micromethod of lead determination in whole blood by atomic absorption with use of graphic furnace. Clin Chem. 1975;21:558–561
  16. Fernandez FJ, Hillegos D. An improved graphite furnace method for the determination of lead in blood using matrix modification and the L'vov platform. Atom Spectrosc. 1982;3:1300–1311
  17. Rosen FJ, Zarate-Salvador C, Trinadad EE. Plasma lead levels in normal and lead-intoxicated children. Pediatrics. 1974;84:45–48
  18. SAS . SAS System, release 8.02, Microsoft Windows TS02M0. Cary (NC): SAS Institute; 2002;
  19. Pollitt E. The developmental and probabilistic nature of the functional consequences of iron-deficiency anemia in children. J Nutr. 2001;131:669S–675S
  20. Mahaffey KR. Nutrition and lead: strategies for public health. Environ Health Perspect. 1995;103(suppl 6):191–196

 Supported by NIH grants R01 HD31606-08 and R01-HD33487-06, to B. L., Principal Investigator.

PII: S0022-3476(03)00540-7

doi: 10.1067/S0022-3476(03)00540-7

The Journal of Pediatrics
Volume 143, Issue 6 , Pages 789-795 , December 2003